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  1. 11081
    “…Taken together, these results unveil a novel role of HAX1 in the non-canonical NF-κB pathway, and provide an important clue that HAX1 is a potential therapeutic target for the treatment of cancer.…”
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    HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization
  2. 11082
    por Duan, Hongying, Qu, Like, Shou, Chengchao
    Publicado 2014
    “…In conclusion, EGFR-PI3K-AKT signaling plays an important role in M. hyorhinis-promoted cell migration in gastric cancer cells, thus providing a clue to the pathogenesis of M. hyorhinis in gastric cancer.…”
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    Activation of EGFR-PI3K-AKT signaling is required for Mycoplasma hyorhinis-promoted gastric cancer cell migration
  3. 11083
    “…Study of miRNAs may provide a new clue for understanding the mechanism of carcinogenesis and a new tool for cancer treatment. …”
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    MicroRNA-153 Inhibits Osteosarcoma Cells Proliferation and Invasion by Targeting TGF-β2
  4. 11084
    “…Our study provides a new clue toward the development of novel promising agents and pathways for inhibiting nuclear hormonal receptor-negative and endocrine-resistant breast cancers.…”
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    Progesterone and Src Family Inhibitor PP1 Synergistically Inhibit Cell Migration and Invasion of Human Basal Phenotype Breast Cancer Cells
  5. 11085
    “…Here we present a knowledge-based CLUster Evaluation (CLUE) approach for identifying the most informative partitioning of a given temporal phosphoproteomics data. …”
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    Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data
  6. 11086
    “…The compound-target network showed that each herbal drug in the BYF formula acted on similar targets, suggesting potential synergistic effects among these herbal drugs. The ClueGo assay, a Cytoscape plugin, revealed that most targets were related to activation of MAP kinase and matrix metalloproteinases. …”
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    Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease
  7. 11087
    “…To solve this problem, a crucial clue can be obtained by examining the remarkable enhancement of magnetic neutron scattering signals appearing in a superconducting phase. …”
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    Suppression of spin-exciton state in hole overdoped iron-based superconductors
  8. 11088
    “…Accumulating evidences have postulated that the redox signalling has implication in macrophage polarization and the key roles of M1 and M2 macrophages in tissue environment have provided the clue for the reasons of ROS abundance in certain phenotype. …”
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    The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
  9. 11089
    “…The source image of the gadolinium-enhanced MRA revealed an intimal flap within the intracranial ICA bifurcation, providing a clue for the diagnosis of a dissecting pseudoaneurysm at the ICA bifurcation due to blunt head trauma. …”
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    Visualization of a Traumatic Pseudoaneurysm at Internal Carotid Artery Bifurcation due to Blunt Head Injury: A Case Report
  10. 11090
    “…Analysis of the ISTX-I, DDH and ICK motifs reveals that the new ISTX-I motif might be an intermediate scaffold between DDH and ICK, and ISTX-I is a clue to the evolutionary link between the DDH and ICK motifs. …”
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    A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds
  11. 11091
    “…Patient experienced gradual resolution of tachyarrhythmia and gradual decrease in QTc interval during hospitalization which supports the evidence of causal relationship between Loperamide overdose and potentially fatal arrhythmias. It also provided the clue that patient may have congenital long QT syndrome which was unmasked by Loperamide causing ventricular arrhythmias. …”
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    Loperamide Induced Life Threatening Ventricular Arrhythmia
  12. 11092
    por Jian, Weilin, He, Daohang, Song, Shaoyun
    Publicado 2016
    “…Taken together, these results would provide new insights into the fungicidal mechanism of stilbenes, as well as an important clue for biology-oriented synthesis of stilbene hybrids with improved bioactivity against plant pathogenic fungi in crop protection.…”
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    Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Oxadiazole-Stilbene Hybrids against Phytopathogenic Fungi
  13. 11093
    “…This could serve as a vulnerability marker and a further clue to the pathogenesis of psychosis.…”
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    Disruptions in neural connectivity associated with reduced susceptibility to a depth inversion illusion in youth at ultra high risk for psychosis
  14. 11094
    “…In addition, we evaluated structural abnormalities of the brain, which may give some clue about the common pathogenic pathway in LGS. …”
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    Brainstem dysfunction in patients with late-onset Lennox–Gastaut syndrome: Voxel-based morphometry and tract-based spatial statistics study
  15. 11095
    “…This study is the first systematic study of zooplankton‐associated diazotrophs, covering a large area of the open ocean, which provide a clue to further study of a possible new hotspot of N(2) fixation.…”
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    Possible association of diazotrophs with marine zooplankton in the Pacific Ocean
  16. 11096
    “…Thus, our data provide a clue that inhibition of autophagy would serve as a novel strategy for enhancing the anti-cancer potential of physapubescin B.…”
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    Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B
  17. 11097
    “…These specific variables, which render sleep patterns of the infants different from those of their mothers, might be a clue to reveal the covert acquisition process of mature circadian rhythms after birth.…”
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    Dependence of nighttime sleep duration in one-month-old infants on alterations in natural and artificial photoperiod
  18. 11098
    “…Taken together, our study showed the first evidence of the novel function of hTRIR in vitro, which provides clue to study the regulatory mechanism of hTR homeostasis in vivo.…”
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    Identification of an RNase that preferentially cleaves A/G nucleotides
  19. 11099
    por Wei, Suyun, Ye, Ning, Yin, Tongming
    Publicado 2017
    “…This study provides new bioinformatic clue for further exploring the genetic mechanism underlying gender determination in willows.…”
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    Detecting the Candidate Gender Determinants by Bioinformatic Prediction of miRNAs and Their Targets from Transcriptome Sequences of the Male and Female Flowers in Salix suchowensis
  20. 11100
    “…The same regression formula, even when daily incremental markings are difficult to visualize, may provide a clue to predicting the proportion of infants born full term and pre-term in an archaeological series.…”
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    New regression formula to estimate the prenatal crown formation time of human deciduous central incisors derived from a Roman Imperial sample (Velia, Salerno, Italy, I-II cent. CE)
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