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  1. 11301
    “…The difference of concentration dependence between AFPs and AFGPs may provide a new clue to help us understand the ice-binding function of these proteins.…”
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    Fish-Derived Antifreeze Proteins and Antifreeze Glycoprotein Exhibit a Different Ice-Binding Property with Increasing Concentration
  2. 11302
    “…In conclusion, we identified Meox1 as a novel transcription factor of P311 gene, providing a new clue of the pathogenesis in fibrosis.…”
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    Molecular Mechanism of Mesenchyme Homeobox 1 in Transforming Growth Factor β1–Induced P311 Gene Transcription in Fibrosis
  3. 11303
    “…The results provided a clue that miRNA156a participating the fatty acid biosynthesis pathway and the detailed molecular mechanism of how it regulates the pathway needs to be further investigated.…”
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    Identification and Characterization of microRNAs in the Developing Seed of Linseed Flax (Linum usitatissimum L.)
  4. 11304
    “…This study may explain the diverse outcomes after vitamin D supplementation in literature and add some clue to the targeted therapy of IBD.…”
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    Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis
  5. 11305
    “…The area under ROC was 0.811 for development group and 0.814 for validation group, and the p values of the two calibration curves were 0.053 and 0.438, the improvement of net reclassification and integrated discrimination are significant in our model. Our results give a clue that the screening models we conducted may be useful for identifying Chinses adults at high risk for diabetes. …”
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    A nomogram model for screening the risk of diabetes in a large-scale Chinese population: an observational study from 345,718 participants
  6. 11306
    “…MCODE plug-in was used for sub-modulization analysis, wherein we identified 25 modules; ClueGo plug-in was used for the pathway’s enrichment analysis, wherein 37 enriched signalling pathways were obtained. …”
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    Topological and system-level protein interaction network (PIN) analyses to deduce molecular mechanism of curcumin
  7. 11307
    “…Further characterization of the novel strains cultured from bats can provide a clue for the determination of the pathogenic properties of those strains.…”
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    Identification of a Novel Yersinia enterocolitica Strain from Bats in Association with a Bat Die-Off That Occurred in Georgia (Caucasus)
  8. 11308
    “…The physicochemical properties of the identified peptides were evaluated. Using ClueGO, approximately 700 gene ontology terms and 15 pathways were defined from the identified protein groups with p-value ≤0.05, covering a wide range of biological processes, cellular components, and molecular functions. …”
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    Proteomic Profiling of Emiliania huxleyi Using a Three-Dimensional Separation Method Combined with Tandem Mass Spectrometry
  9. 11309
    “…CONCLUSION: Age, height, and Tanner staging at presentation can provide a clue toward diagnosis, even before confirmatory tests are available. …”
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    Clinical indicators to define etiology in patients with primary amenorrhea: Lessons from a decade of experience
  10. 11310
    “…CONCLUSION: For some patients with HP, abnormal HRCT findings, such as the lesions in the lungs, can be absorbed on their own, which is an important clue in the diagnosis of the disease. Early diagnosis by lung biopsy is necessary when antigen exposure is unknown.…”
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    Rare imaging findings of hypersensitivity pneumonitis: A case report
  11. 11311
    “…These results provide a valuable clue suggesting that OCPs act as stress sensors by regulating the expression of various genes to protect cancer cells from genotoxic stress.…”
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    Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response
  12. 11312
    “…Genes reported as causal for monogenic pediatric IBD and related syndromes and as risk factors for pediatric and adult complex IBD were analyzed using CytoScape and ClueGO software tools to elucidate significantly enriched Gene Ontology (GO) terms. …”
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    Molecular Genetic Architecture of Monogenic Pediatric IBD Differs from Complex Pediatric and Adult IBD
  13. 11313
    “…Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study.…”
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    Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
  14. 11314
    “…We performed a proteomic analysis using LC-MS/MS-TOF data analyzed through R software and Cytoscape’s ClueGO application, comparing the proteome of kidney endothelial cells, key cell type, subjected to 3, 6, 12, 19, and 24 h of cold ischemia and 6 h reperfusion. …”
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    High Throughput Proteomic Exploration of Hypothermic Preservation Reveals Active Processes within the Cell Associated with Cold Ischemia Kinetic
  15. 11315
    “…In conclusion, we identified C3-mediated immune response as key feature to distinguish COAD and READ, and highlighted C3 as potential biomarker with high prognostic value for clinical application, which provided new clue for precise treatment of COAD.…”
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    Comparative Proteome Identifies Complement Component 3-Mediated Immune Response as Key Difference of Colon Adenocarcinoma and Rectal Adenocarcinoma
  16. 11316
    “…LESSONS: Our report is valuable in that it can contribute to the diagnosis and suggest a clue to the treatment of such a rare pathology. The knowledge in the rare case of entrapment of the tibialis tendon and the understanding of management will be useful when a irreducible Lisfranc dislocation is unsuccessful after an attempt at closed reduction.…”
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    Irreducible Lisfranc injury by tibialis anterior tendon entrapment: A case report
  17. 11317
    “…CONCLUSIONS: Although pathophysiology in P-HUS remains as yet incompletely understood, disordered complement regulation seems to provide a clue to additional insights for pathology, diagnosis, and even targeted treatment.…”
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    Complement activation in children with Streptococcus pneumoniae associated hemolytic uremic syndrome
  18. 11318
    “…Overall, our finding clarifies the effect of stereoisomers, and provides a chemical clue of amino acid herbicides, which may be useful in the development of herbicides from natural substances.…”
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    Enantioselective and Synergistic Herbicidal Activities of Common Amino Acids Against Amaranthus tricolor and Echinochloa crus-galli
  19. 11319
    “…The presence of neurological disturbances associated with laboratory tests alterations is an important clue for the physicians to promptly recognize neurological manifestations of SARS-CoV-2.…”
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    Neurologic Compromise in COVID-19: A Literature Review
  20. 11320
    “…CONCLUSION: Preoperative measurement of NLR is a simple test which may provide an early clue of high-risk pathological features of renal cell cancer.…”
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    Is preoperative neutrophil-to-lymphocyte ratio a red flag which can predict high-risk pathological characteristics in renal cell carcinoma?
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