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  1. 11321
    “…The molecular basis underlying the phenomenon, however, is still not entirely clear. An important clue came from studies performed in budding yeast that indicate that the presence of an intron within a gene results in formation of a multi-looped gene architecture. …”
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    Gene Architecture Facilitates Intron-Mediated Enhancement of Transcription
  2. 11322
    “…Interestingly, however, thyroid hormone levels remained high. A clear clue to the aetiology was provided by consecutive thyroid scintigraphy. …”
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    Challenges in the functional diagnosis of thyroid nodules before surgery for TSH-producing pituitary adenoma
  3. 11323
    “…Our findings provide a clue for understanding how branched rhizome growth is regulated to enhance nutrient acquisition strategies.…”
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    Nitrogen Nutrition Promotes Rhizome Bud Outgrowth via Regulation of Cytokinin Biosynthesis Genes and an Oryza longistaminata Ortholog of FINE CULM 1
  4. 11324
    “…As a conclusion, this study provides an important clue for revealing the origin of C. auris found in Shenyang and could also contribute to improve the understanding of the epidemiological characteristics of C. auris worldwide.…”
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    Genomic epidemiology of Candida auris in a general hospital in Shenyang, China: a three-year surveillance study
  5. 11325
    “…These findings may offer a clue for the elucidation of the mechanism by which inserted foreign coding sequences become transcriptionally activated and fixed in the plant genome.…”
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    De novo activated transcription of inserted foreign coding sequences is inheritable in the plant genome
  6. 11326
    por Chen, Guolin, Mo, Shanshan, Yuan, Di
    Publicado 2021
    “…These findings shed the clue that MTCH1 could be regarded as the potential prognosis biomarker of LIHC and a promising therapeutic target for LIHC.…”
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    Upregulation Mitochondrial Carrier 1 (MTCH1) Is Associated with Cell Proliferation, Invasion, and Migration of Liver Hepatocellular Carcinoma
  7. 11327
    “…Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research and be applied to detect this syndrome earlier. …”
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    A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life
  8. 11328
    “…Andrographolide which is largely present in the leaf extracts of Andrographis paniculata (AP) and is known to exhibit antiviral, antibacterial, and stabilizes Th1/Th2/Th17 responses; taking this clue, we used in silico approaches to see the binding of andrographolide to RBD and NSP12 molecules. …”
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    Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug
  9. 11329
    “…Such a surface normal gives a great clue to be used as an initial guess to the surface normal. …”
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    Color Photometric Stereo Using Multi-Band Camera Constrained by Median Filter and Occluding Boundary
  10. 11330
    “…This study reveals the different effects of SIMT and LIMT, providing an interesting clue for further researches involving gut microbial composition change.…”
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    Small intestinal flora graft alters fecal flora, stool, cytokines and mood status in healthy mice
  11. 11331
    “…In brief, our findings did not provide an inspiring clue for the hypothesis that SUA may be beneficial to lumbar spine BMD. …”
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    No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study
  12. 11332
    “…Evaluation of the causative mechanism of injury is the clue. A rare type of mechanism of injury also should be kept in mind to prevent the delay in diagnosis and treatment.…”
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    Pediatric anterior elbow dislocation due to a rare mechanism of injury: A case report
  13. 11333
    “…A close look of the inflammatory markers gives an invaluable clue in managing this condition. Rapid deterioration might occur anytime in this setting and the need of cardiopulmonary support seems inevitable. …”
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    In-depth review of cardiopulmonary support in COVID-19 patients with heart failure
  14. 11334
    por Saba, Neelam, Irshad, Saba
    Publicado 2021
    “…Congenital cataract was developed secondarily in these patients and provided a clue for the early diagnosis of metabolic disorders like homocystinuria to prevent further complications and morbidity.…”
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    Congenital cataract: An ocular manifestation of classical homocystinuria
  15. 11335
    “…AVAILABILITY AND IMPLEMENTATION: The data is freely available at clue.io/data (section Contests) and the software is on GitHub at https://github.com/cmap/gene_deconvolution_challenge SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.…”
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    Improving deconvolution methods in biology through open innovation competitions: an application to the connectivity map
  16. 11336
    “…The differences in cerebral blood flow under the pre-frailty conditions may be a clue to detecting cognitive decline earlier.…”
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    Brain Activity in the Prefrontal Cortex during Cognitive Tasks and Dual Tasks in Community-Dwelling Elderly People with Pre-Frailty: A Pilot Study for Early Detection of Cognitive Decline
  17. 11337
    “…By the experiments, it is found that the proposed method is able to capture the moment of large facial movements even for people with micro facial expressions and obtain information that can be used as a clue to investigate their response to care.…”
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    Toward Capturing Scientific Evidence in Elderly Care: Efficient Extraction of Changing Facial Feature Points †
  18. 11338
    “…However, no definitive clue about the molecular mechanism linking sorafenib and EGF signalling pathway has been established so far. …”
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    ERK5 signalling pathway is a novel target of sorafenib: Implication in EGF biology
  19. 11339
    “…As the relationship of microbiota and skin infection has not been clarified, our findings could provide a clue to a mechanism through which coix seed could promote the spontaneous regression of viral skin infections.…”
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    Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults
  20. 11340
    “…The initial study of screening whole extracts or fractions and later the isolation of secondary compounds and their mechanism of action study gives a clue of potential therapeutic agents for future drug development. …”
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    Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development
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