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11501por Bartels, Stephan, Schipper, Elisa, Hasemeier, Britta, Kreipe, Hans, Lehmann, Ulrich“…Demonstration of clonal hematopoiesis provides a diagnostic clue and has become possible by comprehensive mutation profiling of a number of frequently mutated genes, some of them with large coding regions. …”
Publicado 2016
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11502por Xu, Jin, Liu, Deshui, Zhang, Yongliang, Wang, Ying, Han, Chenggui, Li, Dawei, Yu, Jia-Lin, Wang, Xian-Bing“…Our work reveals the profiles of siRNAs of BBSV and sat-RNA and provides an additional clue to investigate the complicated interaction between the helper virus and sat-RNA.…”
Publicado 2016
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11503“…Our study provides novel clue toward the understanding of monocyte adaptation and memory toward distinct TLR ligands.…”
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11504“…Subsequently, cardiac computed tomography, which revealed the focally calcific pericardium encircling the left ventricle, gave us a clue to the diagnosis of localized constrictive pericarditis. …”
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11505por Zamanian Azodi, Mona, Peyvandi, Hassan, Rostami-Nejad, Mohammad, Safaei, Akram, Rostami, Kamran, Vafaee, Reza, Heidari, Mohammadhossein, Hosseini, Mostafa, Zali, Mohammad Reza“…The networks of related differentially expressed protein were explored using Cytoscape 3.3 and the PPI analysis methods such as MCODE and ClueGO. RESULTS: According to the network analysis Ubiquitin C, Heat shock protein 90kDa alpha (cytosolic and Grp94); class A, B and 1 member, Heat shock 70kDa protein, and protein 5 (glucose-regulated protein, 78kDa), T-complex, Chaperon in containing TCP1; subunit 7 (beta) and subunit 4 (delta) and subunit 2 (beta), have been introduced as hub-bottlnecks proteins. …”
Publicado 2016
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11506“…Taken together, these findings suggest novel information and clue of the anticolitis effects of KIOM-MA128 via regulation of tight junction.…”
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11507por Kiriyama, Muneyasu, Ebata, Tomoki, Yokoyama, Yukihiro, Igami, Tsuyoshi, Sugawara, Gen, Mizuno, Takashi, Yamaguchi, Junpei, Nagino, Masato“…In this complicated setting, demonstrating the communication to the responsible dilated duct is a clue to the diagnosis. Multidirectional MDCT images succeeded in specifically demonstrating this communication, which is insensitive to the presence of excessive mucobilia.…”
Publicado 2017
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11508por Lee, Young Ah, Chun, Peter, Hwang, Eun Ha, Mun, Sang Wook, Lee, Yeoun Joo, Park, Jae Hong“…Inspection of the anus should be mandatory in Korean children with suspicious CD, as perianal fistulas, abscesses, and anal skin tags may be the first clue to the diagnosis of CD.…”
Publicado 2016
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11509por Khan, Nicholas E., Bauer, Andrew J., Doros, Leslie, Schultz, Kris Ann P., Decastro, Rosamma M., Harney, Laura A., Kase, Ron G., Carr, Ann G., Harris, Anne K., Williams, Gretchen M., Dehner, Louis P., Messinger, Yoav H., Stewart, Douglas R.“…Like some of the other tumor-predisposition disorders, macrocephaly may be a useful, albeit a subtle, clinical clue to the DICER1 syndrome diagnosis.…”
Publicado 2016
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11510por Allvin, Renée, Berndtzon, Magnus, Carlzon, Liisa, Edelbring, Samuel, Hult, Håkan, Hultin, Magnus, Karlgren, Klas, Masiello, Italo, Södersved Källestedt, Marie-Louise, Tamás, Éva“…CONCLUSION: Experienced simulation educators’ pedagogical development was based on self-confidence in the educator role, and not on a deeper theoretical understanding of teaching and learning. This is the first clue to gain increased understanding regarding educational level and possible education needs among simulation educators, and it might generate several lines of research for further studies.…”
Publicado 2017
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11511“…Moreover, blocking clathrin-mediated endocytosis or depleting cholesterol from the cell membrane leads to a strong inhibition of viral infection, as assessed by plaque assays. Following this clue, we found that early endosomes and caveolae-derived vesicles are both implicated as target membranes for MAYV fusion. …”
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11512por Brandetti, Elisa, Veneziani, Irene, Melaiu, Ombretta, Pezzolo, Annalisa, Castellano, Aurora, Boldrini, Renata, Ferretti, Elisa, Fruci, Doriana, Moretta, Lorenzo, Pistoia, Vito, Locatelli, Franco, Cifaldi, Loredana“…Taken together, these results provide the first demonstration that MYCN acts as an immunosuppressive oncogene in NB cells that negatively regulates the expression of ligands for NKG2D and DNAM-1 NK-cell-activating receptors. Our study provides a clue to exploit MYCN expression levels as a biomarker to predict the efficacy of NK-cell-based immunotherapy in NB patients.…”
Publicado 2017
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11513“…This study attempts to establish macrocontrol regulation system and knowledge that miR-212-3p/132-3p effected the epilepsy, for this literature search, miRbase, Vienna RNAfold webserver, Human miRNA tissue atlas, DIANA-TarBase, miRtarbase, STRING, TargetScanhuman, Cytoscape plugin ClueGO + Cluepedia+STRING, DAVID Bioinformatics Resources, Starbase, GeneCards suite and GEO database are comprehensive employed, miR-132-3p/212-3p and its target gene were found have highly expressed in brain and lots of molecular function and metabolic pathways associated with epilepsy may be intervened by it. …”
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11514“…This work may further the study as to the physiological function of AcCATPO, especially clarify its involvement in betalain biosynthesis, and provide a clue to elucidate more non-canonic PTS.…”
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11515por Shaeghi, Mansoureh, Dehghan, Hossein, Pakdad, Kamran, Nikpour, Fatemeh, Absavaran, Azad, Sofizadeh, Aioub, Akhavan, Amir Ahmad, Vatandoost, Hassan, Aghai-Afshar, Abbass“…Therefore the understanding of ecological specifications of aquatic insects could provide a clue for further Arthropod-borne disease control. …”
Publicado 2017
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11516por Crocetti, Emanuele, Giusti, Francesco, Martos, Carmen, Randi, Giorgia, Dyba, Tadeusz, Bettio, Manola“…The 95% confidence interval of the ASR for Nordic countries as a whole did not overlap those of the majority of the single countries; in fact, the r/R – which provides a clue for the amount of underlying geographical variability – was rather large (57.1%). …”
Publicado 2017
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11517por Jiang, Shuai, Wang, Lingling, Huang, Mengmeng, Jia, Zhihao, Weinert, Tobias, Warkentin, Eberhard, Liu, Conghui, Song, Xiaorui, Zhang, Haixia, Witt, Jennifer, Qiu, Limei, Peng, Guohong, Song, Linsheng“…The present result clearly indicated that CgDM9CP-1 was a PRR, and it provided an important clue for the better understanding of DM9CP function.…”
Publicado 2017
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11518“…Our results reveal that OsCDPK1 plays novel key roles in the cross-talk and mediation of the balance between stress response and development and provides a clue for improving grain yield and disease resistance simultaneously in rice.…”
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11519por Frattini, Véronique, Pagnotta, Stefano M., Tala, Fan, Jerry J., Russo, Marco V., Lee, Sang Bae, Garofano, Luciano, Zhang, Jing, Shi, Peiguo, Lewis, Genevieve, Sanson, Heloise, Frederick, Vanessa, Castano, Angelica M., Cerulo, Luigi, Rolland, Delphine C. M., Mall, Raghvendra, Mokhtari, Karima, Elenitoba-Johnson, Kojo S.J., Sanson, Marc, Huang, Xi, Ceccarelli, Michele, Lasorella, Anna, Iavarone, Antonio“…Our analyses uncover the oncogenic circuit engaged by F3-T3, expose reliance on mitochondrial respiration as unexpected therapeutic opportunity for F3-T3-positive tumors and provide a clue to the genetic alterations that initiate the chain of metabolic responses driving mitochondrial metabolism in cancer.…”
Publicado 2018
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11520por Yang, Kuender D., Wu, Chih-Chiang, Lee, Ming-Tsung, Ou, Chia-Yu, Chang, Jen-Chieh, Wang, Chih-Lu, Chuang, Hau, Kuo, Ho-Chang, Chen, Chie-Pein, Hsu, Te-Yao“…This highlights a potential non-invasive clue in a subtropical region for the early prediction, treatment and prevention of childhood allergy diseases in infancy.…”
Publicado 2017
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