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  1. 11561
    por Bi, Ke-Wei, Wei, Xu-Ge, Qin, Xiao-Xue, Li, Bo
    Publicado 2020
    “…Thus, the levels of BTK might be useful for outlining the prognosis of LUAD patients and especially be a clue that the status of TME transition from immune-dominant to metabolic activity, which offered an extra insight for therapeutics of LUAD.…”
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    BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining
  2. 11562
    “…Therefore, the N-terminal region of hSNF5(171–258) plays an important role in tumorigenesis and our data will provide a structural clue for the pathogenesis of Rhabdoid tumors and malignant melanomas that originate from mutations in the N-terminal loop region of hSNF5.…”
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    A Coil-to-Helix Transition Serves as a Binding Motif for hSNF5 and BAF155 Interaction
  3. 11563
    “…CONCLUSIONS: Taken together, our results demonstrated that Nrdp1 contributed to M1/M2 macrophage polarization and neuroinflammation via ubiquitination and activation of C/EBP-β in ICH. miR-494 may provide a promising therapeutic clue for ICH.…”
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    MiRNA-494 enhances M1 macrophage polarization via Nrdp1 in ICH mice model
  4. 11564
    “…So, these relationships may provide clue on obesity and its effect on reproductive performance and strengthened the possibility of the characterized BMI/LI as obesity marker for breeding selection in male cane rat.…”
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    Relationship between Body Mass Index (BMI) and testicular and hormonal parameters of sexually active male greater cane rats (Thryonomys swinderianus)
  5. 11565
    por Safari, Elham, Torabi, Mehdi
    Publicado 2020
    “…CONCLUSION: ETCO(2) post-intubation and serum lactate may be considered as prognostic factors for intubated multiple trauma patients referring to the emergency department, which can give the clinician an important clue in early prediction of the hospital mortality.…”
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    Relationship between End-Tidal CO(2) (ETCO(2)) and Lactate and their Role in Predicting Hospital Mortality in Critically Ill Trauma Patients; A Cohort Study
  6. 11566
    por Liu, Xiao-hua, Yang, Jian-min
    Publicado 2020
    “…In the second admission, chest tomographic angiography found a chordae shadow in the right middle lobe, was the first clue for pulmonary arteriovenous fistula (PAVF), thereafter further confirmed by the enhanced pulmonary computed tomographic angiography. …”
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    Management of paradoxical embolism in a patient with coexisting patent foramen ovale and masked pulmonary arteriovenous fistula: A case report
  7. 11567
    “…This study provides a clue to understanding the mechanism underlying the switch in direction of chloroplast relocation in response to light and temperature.…”
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    The cold-induced switch in direction of chloroplast relocation occurs independently of changes in endogenous phototropin levels
  8. 11568
    “…In this study, we swapped p53 protein expression in human and mouse cells to find the clue of this difference between species. Human p53 expression in mouse cells upregulated PIERCE1 expression, suggesting that p53-responsive elements on the PIERCE1 promoter are crucial, but not the p53 protein itself. …”
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    Divergence of the PIERCE1 expression between mice and humans as a p53 target gene
  9. 11569
    “…Retinal pigmentation with an RNFL defect is a clue for DH, although RNFL showed no significant change. …”
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    Optic disc hemorrhage in nonglaucomatous eyes: A cross-sectional study with average 8-year follow-up
  10. 11570
    “…Polarized neutron diffraction allows an analysis of the magnitude of the spin density over magnetic and non-magnetic ions (the organic ligand and the counterion), which can give a clue to explain the low saturation on the Fe(III) sites and the correlation with the physical measurements. …”
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    Spin-density studies of the multiferroic metal-organic compound [NH(2)(CH(3))(2)][Fe(III)Fe(II)(HCOO)(6)]
  11. 11571
    “…CONCLUSIONS: We detected two new findings which have not been described previously for subungual hematoma: the first one is “blue-white colour” which is known as an important clue to melanoma. The second one is granular leukonychia localized on the hematoma. …”
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    Dermoscopic diagnosis of subungual hematoma: new observations
  12. 11572
    “…This study investigated the implication of MicroRNA‐326 in OS proliferation and metastasis to provide the clue for the treatment of metastatic OS. This study knocked down SP1 in MG63 and 143B cells and then performed Microarray assay to find the expression of miRNAs that were influenced by SP1. …”
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    The inhibition of microRNA‐326 by SP1/HDAC1 contributes to proliferation and metastasis of osteosarcoma through promoting SMO expression
  13. 11573
    “…We hypothesized that the location of residual neoplastic cells in resected specimens following NAC could provide a clue as to the mechanisms of resistance. PDAC cells invade the stroma but can also invade back into and spread via the pancreatic ducts, which has been referred to as “cancerization of ducts” (COD). …”
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    Intraductal Pancreatic Cancer is Less Responsive Than Cancer in the Stroma to Neoadjuvant Chemotherapy
  14. 11574
    por Lu, Peng, Huang, Jingjing
    Publicado 2020
    “…The anterior and posterior ultrasound findings may give a clue on the potential mechanism.…”
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    Ultrasound findings in a case of Eales’ disease and ocular trauma with anterior chamber cholesterolosis
  15. 11575
    “…The present study could provide neurobiological clue for the possible correlation between the amitriptyline use and the risk of developing neurodegenerative diseases.…”
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    Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells
  16. 11576
    “…Knowledge of the prevalence of venous thromboembolism, which is often undetected clinically, will help save lives as appropriate interventions can be made as well as provide a general clue to clinicians on detecting venous thromboembolism and pulmonary embolism. …”
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    Prevalence of Venous Thromboembolism in Kumasi: A Postmortem-Based Study in a Tertiary Hospital in Ghana
  17. 11577
    por Singh, Pratichi
    Publicado 2020
    “…Finally, the enrichment analysis was executed using ClueGO. RESULTS: As a result, dopamine receptor D2, brain derived neurotrophic factor, HTRF1A, and dopamine receptor D4 were recognized as hub genes among the reported ADHD genes. …”
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    Network and pathway enrichment analysis of Attention Deficit/Hyperactivity Disorder candidate genes
  18. 11578
    “…One of the most critical pathophysiological mechanisms of CSVD is endothelium dysfunction and subsequent blood-brain barrier (BBB) leakage, which gives a clue in the identification of the disease by detecting circulating biological markers of BBB disruption. …”
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    Age-related cerebral small vessel disease and inflammaging
  19. 11579
    “…Even though the adverse effects of some of these drugs may overweight their benefits, considering their mechanisms and structures may give a clue for designing novel drugs in the future. Furthermore, the antiviral effect and IFN-modifying mechanisms possessed by some of these drugs might lead to a synergistic effect against SARS-CoV-2, which deserve to be evaluated in further investigations.…”
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    Interferon-inducer antivirals: Potential candidates to combat COVID-19
  20. 11580
    “…These new insights into molecular profiles of GCTs lead to a better understanding of the complex pathogenesis of GCTs, and will hopefully provide a clue to future development of new treatments.…”
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    GCT-52. TRANSCRIPTOME OF CENTRAL NERVOUS SYSTEM GERM CELL TUMOR REVEALS ITS PATHOGENESIS AND CONTRASTS WITH TESTICULAR COUNTERPARTS IN INTEGRATED OMICS ANALYSIS
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