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11821por Ma, Mingsheng, Cao, Run, Wang, Wei, Wang, Biying, Yang, Yichen, Huang, Yunchao, Zhao, Guangqiang, Ye, Lianhua“…CONCLUSION: This meta-analysis revealed that the high plasma D-dimer level leads to lower survival than in the low D-dimer level, which might provide an important clue for high plasma D-dimer level as an independent factor of poor prognosis in patients with lung cancer. …”
Publicado 2021
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11822por Liang, Xiaonan, He, Mingwei, Zhu, Bo, Zhu, Yongjia, He, Xixi, Liu, Dachang, Wei, Qingjun“…These findings offer a valuable clue for us to better understand the underlying mechanisms involved in osteoblast differentiation of hBMSCs caused by DHEA and assist in applying DHEA in hBMSCs-based therapy for osteogenic regeneration.…”
Publicado 2021
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11823“…Our data may provide a novel clue to indicate the underlying molecular mechanisms of AAA formation in terms of immune infiltration.…”
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11824“…The characteristics on imaging studies, including greater enhancement and higher tumor-to-kidney attenuation ratio, may provide a clue for diagnosis, but ureteroscopy and histopathology are the criterion standards and should be considered as part of routine preoperative assessment. …”
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11825por Warren, Annabelle M, Ebeling, Peter R, Grill, Vivian, Seeman, Ego, Sztal-Mazer, Shoshana“…Low serum alkaline phosphatase (ALP) provides a clue to the diagnosis. Elevated serum vitamin B6 (an ALP substrate) is indicative of HPP, while identification of a mutation in the ALPL gene is confirmatory. …”
Publicado 2021
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11826por Fiedorowicz, Katarzyna, Wargocka-Matuszewska, Weronika, Ambrożkiewicz, Karolina A., Rugowska, Anna, Cheda, Łukasz, Fiedorowicz, Michał, Zimna, Agnieszka, Drabik, Monika, Borkowski, Szymon, Świątkiewicz, Maciej, Bogorodzki, Piotr, Grieb, Paweł, Hamankiewicz, Paulina, Kolanowski, Tomasz J., Rozwadowska, Natalia, Kozłowska, Urszula, Klimczak, Aleksandra, Kolasiński, Jerzy, Rogulski, Zbigniew, Kurpisz, Maciej“…Current treatment protocols for myocardial infarction improve the outcome of disease to some extent but do not provide the clue for full regeneration of the heart tissues. …”
Publicado 2021
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11827“…Furthermore, we established a nomogram for predicting risk of skip metastasis, which was able to effectively predict the potential risk of skip metastasis in patients without preoperative LNM clue.…”
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11828por Yeole, Ujwal, Rao, K. V.L. Narsinga, Beniwal, Manish, Sivakoti, Sumitra, Santosh, Vani, Somanna, Sampath“…Preoperative diagnosis is challenging; however, few radiological findings may give a clue toward it. As a disease entity overall, it has a poor outcome with a high rate of fatality.…”
Publicado 2021
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11829por Cavin, Lionel, Toriño, Pablo, Van Vranken, Nathan, Carter, Bradley, Polcyn, Michael J., Winkler, Dale“…The link between a wide geographic distribution and the resilience to extinction demonstrated here for Mawsonia is a clue that a similar situation existed for Latimeria, which allowed this genus to live for tens of millions of years.…”
Publicado 2021
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11830por Chrostowski, Jakub, Majos, Marcin, Walczak, Andrzej, Wachowski, Mariusz, Majos, Agata“…CONCLUSIONS: Neuroradiological indices of the vascular disease do not provide an unequivocal clue to the pathogenesis of CSVD in patients with severe AS. …”
Publicado 2021
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11831por Karunaratna, Sumudu, Ranaweera, Dewanee, Vitharana, Harshini, Ranaweera, Prasad, Mendis, Kamini, Fernando, Deepika“…Eliciting a history of travel to a malaria-endemic country could provide an important and discerning clue to suspect and test for malaria in such patients.…”
Publicado 2021
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11832“…SOX10 belongs to a family of 20 SRY (sex-determining region Y)-related high mobility group box-containing (SOX) proteins, most of which contribute to cell type specification and differentiation of various lineages. The first clue that SOX10 is essential for development, especially in the neural crest, came with the discovery that heterozygous mutations occurring within and around SOX10 cause Waardenburg syndrome type 4. …”
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11833por Zhuang, Yin, Song, Sheng, Xiao, Dan, Liu, Xueguang, Han, Xiaofei, Du, Shihao, Li, Yuan, He, Yanming, Zhang, Shujun“…Therefore, insights from this work may provide a clue for targeted molecular therapy of intervertebral disc degeneration.…”
Publicado 2022
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11834por Li, Zhuo, Lian, Zhiwen, Ma, Jianchao, Zhang, Li, Lian, Xingji, Liu, Shuangxin, Xie, Jianteng, Feng, Zhonglin, Lin, Ting, Zhang, Hong, Liang, Xinling“…This will provide a new clue for preventing podocyte from damage.…”
Publicado 2021
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11835por Wilson, Ava C., Chiles, Joe, Ashish, Shah, Chanda, Diptiman, Kumar, Preeti L., Mobley, James A., Neptune, Enid R., Thannickal, Victor J., McDonald, Merry-Lynn N.“…Specifically, four genes (BASP1, HSD17B6, CDH11, and TNS1) have been associated with pirfenidone, while five genes (CLINT1, CADM1, MTDH, SYDE1, and MCTS1) have been associated with nintedanib, and MYDGF has been implicated with treatment using both drugs. Using the Clue Drug Repurposing Hub, succinic acid was highlighted as a metabolite regulated by the protein encoded by HSD17B6. …”
Publicado 2022
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11836por Tovichien, Prakarn, Rattananont, Krittin, Kulthamrongsri, Narathorn, Chanvanichtrakool, Mongkol, Yangthara, Buranee“…CONCLUSION: Diagnosis of CCHS in neonates includes the main clue of the absence of hypercapnic ventilatory response which worsens during non-rapid eye movement (NREM) sleep after exclusion of other causes. …”
Publicado 2022
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11837por Anjos, Liliana, Pinto, Patrícia I.S., Santos, Soraia, Estêvão, M. Dulce, Santa, Cátia, Manadas, Bruno, Canário, Adelino V.M., Power, Deborah M.“…The main biological processes and KEGG pathways affected by E2 or FLX treatments were identified using Cytoscape/ClueGO enrichment analyses.…”
Publicado 2022
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11838por Gong, Hui, Lyu, Xing, Dong, Lini, Tan, Shengyu, Li, Shizhen, Peng, Jieting, Liu, Yang, Zhang, Xiangyu“…This study may provide a new clue for the treatment of heart failure with OSA.…”
Publicado 2022
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11839por Song, Na, Tu, Haitao, Li, Ying, Xiong, Weijian, Zhang, Ling, Liu, Hong, Ding, Weisen, Long, Mei, Ren, Dewei, Zhong, Jin“…GO analysis and KEGG pathway analysis of targets were performed using Cytoscape ClueGO. Molecular docking experiments and Co-IP are used to prove that luteolin and PLZF can be combined. …”
Publicado 2022
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11840por Yang, Fan, Sun, Rui, Hou, Zeng, Zhang, Fang‐Lin, Xiao, Yi, Yang, Yun‐Song, Yang, Shao‐Ying, Xie, Yi‐Fan, Liu, Ying‐Ying, Luo, Cheng, Liu, Guang‐Yu, Shao, Zhi‐Min, Li, Da‐Qiang“…These results also provide new clue for further design of novel small‐molecule inhibitors of MORC2 for anticancer therapeutic application.…”
Publicado 2022
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