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  1. 12241
    “…Thus, DSG might provide a new clue for the drug therapy of CCA. CONCLUSION: In our data, DSG was found to have efficient antitumor potential of human CCA cells in vitro and in vivo.…”
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    Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis
  2. 12242
    “…In clinical isolates, the simultaneous interference with multiple genes mediating overlapping drug resistance might be the clue for successful phenotype reversal.…”
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    Exploring the Potential of CRISPR-Cas9 Under Challenging Conditions: Facing High-Copy Plasmids and Counteracting Beta-Lactam Resistance in Clinical Strains of Enterobacteriaceae
  3. 12243
    “…Our meta-analyses results indicated that the Val66Met polymorphism was significantly linked with smoking persistence based on either all the chosen samples (N = 10,160; Random and fixed models: pooled OR = 1.23; 95% CI = 1.03–1.46; P value = 0.012) or Asian samples (N = 2,095; Fixed model: pooled OR = 1.25; 95% CI = 1.01–1.54; P value = 0.044; Random model: pooled OR = 1.25; 95% CI = 1.001–1.56; P value = 0.049). No significant clue of bias in publications or heterogeneity across studies was detected. …”
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    Meta-analytic method reveal a significant association of theBDNF Val66Met variant with smoking persistence based on a large samples
  4. 12244
    “…A search of the DGIdb, KEGG, and CLUE databases revealed a set of drugs/chemicals targeting glaucoma genes. …”
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    A comprehensive map of disease networks and molecular drug discoveries for glaucoma
  5. 12245
    “…This study reports the first case of ureteric sarcoidosis controlled with medical therapy where a differential diagnosis was performed based on the diagnostic clue of hypercalcemia. A definitive diagnosis was established without surgical resection of the ureter. …”
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    Relevance of concurrent hypercalcemia in ureteric sarcoidosis complicated with bladder urothelial carcinoma: a case report
  6. 12246
    “…We provide evidences to implement ERAS and a clue of the most optimal indications for ERAS.…”
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    Interactions between the enhanced recovery after surgery pathway and risk factors for lung infections after pulmonary malignancy operation
  7. 12247
    “…This study underlines the clue for understanding the clinical significance of ACE2 in COVID-19 patients with LUAD comorbidity.…”
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    Expression of SARS-COV-2 cell receptor gene ACE2 is associated with immunosuppression and metabolic reprogramming in lung adenocarcinoma based on bioinformatics analyses of gene expression profiles
  8. 12248
    “…These characteristics are different from a branch duct type IPMN and can be a clue to suspect ITPN in BD.…”
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    A case of intraductal tubulopapillary neoplasm of the pancreas in a branch duct: a rare case report and literature review
  9. 12249
    “…Epigenetic inactivation of GATA3 may provide a new clue to the peculiar biology of this rare neoplasia.…”
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    Chromosome 2q gain and epigenetic silencing of GATA3 in microglandular adenosis of the breast
  10. 12250
    “…BACKGROUND: Knowledge of the normal variation in AF size may be helpful to cue early diagnosis of congenital hypothyroidism, hyperthyroidism, cardiac disease, meningitis, degree of dehydration or provide a clue to disorders of neural and skeletal development. …”
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    Determining Anterior Fontanel Size and Associated Factors Among Term Neonates on the First Day of Life Born at Jimma University Medical Center (JUMC), Southwest Ethiopia: A Linear Regression Model
  11. 12251
    “…CONCLUSION: Our data suggested that patients with FSZ exhibited similar performance in processing inverted faces and upright faces, but were less efficient than controls; and for these patients, inverted faces are processed less efficiently than upright faces. We also provided a clue that the mechanism under abnormal FIE might be related to an aberrant activation of non-face-selective areas instead of abnormal activation of face-specific areas in patients with schizophrenia. …”
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    Cortical Pathways or Mechanism in the Face Inversion Effect in Patients with First-Episode Schizophrenia
  12. 12252
    “…METHODS: The causative genes of PCOS were searched using the GWAS catalog, and pathway analysis was performed using ClueGO. SNPs were extracted using an Ensembl genome browser, and missense variants were shortlisted. …”
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    Conceptualization of functional single nucleotide polymorphisms of polycystic ovarian syndrome genes: an in silico approach
  13. 12253
    “…We herein report a patient with metastatic medullary thyroid carcinoma to the breast for whom measuring the calcitonin level was an important clue to the correct diagnosis. CASE PRESENTATION: A 54-year-old woman visited our hospital for the treatment of recurrent metastatic medullary thyroid carcinoma due to multiple endocrine neoplasia 2A and breast cancer. …”
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    Breast metastasis from medullary thyroid carcinoma: a report of a case
  14. 12254
    “…By analyzing the published ATAC-seq and ChIP-seq data, we found that Tcf1 directly targeted 110 NK cell-related genes which displayed differential accessibility in the absence of Tcf1. Along with this clue, we further confirmed that a series of essential regulators were expressed aberrantly in distinct BM NK subsets with conditional ablating Tcf1 at NKP stage. …”
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    Tcf1 Sustains the Expression of Multiple Regulators in Promoting Early Natural Killer Cell Development
  15. 12255
    “…CONCLUSIONS: incidental mammary uptake during an FDG-PET scan may represent a clue suggesting to investigate PET findings. In this subset of patients, early diagnosis may lead to a change in clinical management with a favorable impact on prognosis and a significant reduction in healthcare costs.…”
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    Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology
  16. 12256
    por Iba, Toshiaki, Levy, Jerrold H.
    Publicado 2022
    “…VITT/TTS is rare, and thrombocytopenia can be the clue to detect this serious complication. It is important to consider that thrombocytopenia and/or thromboembolism are not events limited to post-vaccination with vectored vaccine, but are also seen rarely after vaccination with other vaccines. …”
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    Thrombosis and thrombocytopenia in COVID-19 and after COVID-19 vaccination()()
  17. 12257
    “…Biological pathways and functions enriched for proteins were identified using ClueGo pathway analyses. RESULTS: Adiponectin, complement component C7 and fibulin-1, a component of heart valve matrix, were significantly higher in cases when compared with controls. …”
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    Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases
  18. 12258
    “…This massive dataset would serve as an outstanding clue for further study in tobacco and other plant species for nutrient physiology and molecular regulation mechanism.…”
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    Comprehensive Transcriptome Analysis Uncovers Hub Long Non-coding RNAs Regulating Potassium Use Efficiency in Nicotiana tabacum
  19. 12259
    “…Similarly, the higher expression of HIRM2 might attribute to the high expression of protein disulfide isomerase gene family (PDI) family genes in adulthood, which provides an important clue that why adult leeches rather than young leeches are widely used in clinical therapeutics and traditional Chinese medicine.…”
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    Comprehensive Transcriptome Sequencing Analysis of Hirudinaria manillensis in Different Growth Periods
  20. 12260
    por Lv, Kun, Cao, Xin, Geng, Dao-Ying, Zhang, Jun
    Publicado 2022
    “…CONCLUSION: An elevated serum IgG4 concentration is the main clue for diagnosis of IgG4-RD. Imaging combined with laboratory testing is useful for preoperative diagnosis of IgG4-RH.…”
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    Imaging findings of immunoglobin G4-related hypophysitis: A case report
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