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  1. 12281
    “…This study revealed a novel mechanism of Brucella infection-induced abortion, thus providing a new clue for the study of safer Brucella attenuated vaccines.…”
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    Erythronate utilization activates VdtR regulating its metabolism to promote Brucella proliferation, inducing abortion in mice
  2. 12282
    “…These observations appear to imply that the development of oedema requires a certain degree of immunocompetence, which is an interesting clue to the pathophysiology of oedema in severe malnutrition.…”
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    Severe malnutrition with and without HIV-1 infection in hospitalised children in Kampala, Uganda: differences in clinical features, haematological findings and CD4(+ )cell counts
  3. 12283
    “…However informative, this representation is static and provides no clue about the dynamic nature of protein interactions inside the cell. …”
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    ProtNet: a tool for stochastic simulations of protein interaction networks dynamics
  4. 12284
    “…Each node's, or sub-network's, predominant color, ranging from green (significant for tissue/condition A) over yellow (not significant for either tissue/condition) to red (significant for tissue/condition B), thus gives an immediate visual clue on which molecules—differentially expressed or not—may play pivotal roles in the tissues or conditions under examination. …”
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    DEEP—A tool for differential expression effector prediction
  5. 12285
    “…In an effort to identify such markers, and thereby provide a clue to the complex equation malaria vaccine development is facing, we investigated the relationship between protection acquired through exposure in the field with naturally occurring immune responses (i.e., induced by the parasite) to molecules that are considered as valuable vaccine candidates. …”
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    Long-Term Clinical Protection from Falciparum Malaria Is Strongly Associated with IgG3 Antibodies to Merozoite Surface Protein 3
  6. 12286
    Publicado 1996
    “…Thus, mechanistically, the inhibition is analogous to veto, and might be called self-veto. As a clue to a possible mechanism, we found that free I-10 peptide induced apparent downregulation of expression of specific TCR as well as interleukin 2 receptor, CD69, lymphocyte function-associated antigen 1, and CD8. …”
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    Inactivation of human immunodeficiency virus (HIV)-1 envelope-specific CD8+ cytotoxic T lymphocytes by free antigenic peptide: a self-veto mechanism?
  7. 12287
    “…This study provides an important structural clue for the rational design of drugs to inhibit processing of APP at the γ-site without interfering with Notch processing.…”
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    Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1
  8. 12288
    “…The observed effects could provide not only a clue to the long-standing evolutionary enigma of the origin of RhD polymorphism in humans (the effect of balancing selection), but might also be the missing piece in the puzzle of the physiological function of the RhD molecule.…”
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    Increased incidence of traffic accidents in Toxoplasma-infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study
  9. 12289
    “…The identification of this small but important proportion of high risk HCM patients has been the clue in the clinical evaluation of these patients. …”
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    Identification of high risk patients with hypertrophic cardiomyopathy in a northern Greek population
  10. 12290
    “…BACKGROUND: Spontaneous circulation returns to less than half of adult cardiac arrest victims who received in-hospital resuscitation. One clue for this disheartening outcome arises from the prognosis that asystole invariably takes place, after a time lag, on diagnosis of brain stem death. …”
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    Brain Stem Death as the Vital Determinant for Resumption of Spontaneous Circulation after Cardiac Arrest in Rats
  11. 12291
    “…The in vivo substrate(s) of AOC3 is/are also unknown, but could provide an invaluable clue to the enzyme's function. Expression of untagged, soluble human AOC3 in insect cells provides a relatively simple means of obtaining pure enzyme. …”
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    Implication for Functions of the Ectopic Adipocyte Copper Amine Oxidase (AOC3) from Purified Enzyme and Cell-Based Kinetic Studies
  12. 12292
    “…Our findings provide a new clue to searching predictive markers of the response to L-OHP, suggesting that S100A10 is expected to be one of the candidate protein markers.…”
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    S100A10 protein expression is associated with oxaliplatin sensitivity in human colorectal cancer cells
  13. 12293
    “…Moreover, the ability of CfC1qDC to interact with immunoglobulins provided a clue to understand the evolution of classical pathway in complement system.…”
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    A C1q Domain Containing Protein from Scallop Chlamys farreri Serving as Pattern Recognition Receptor with Heat-Aggregated IgG Binding Activity
  14. 12294
    “…Our findings provide a new clue to better understand the mechanism of disordered lipid metabolism in association with type 2 diabetes.…”
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    Integrated lipidomics and transcriptomic analysis of peripheral blood reveals significantly enriched pathways in type 2 diabetes mellitus
  15. 12295
    “…These findings firstly demonstrated the aggravated effects of B19 NS1 but not VP1u or VP2 protein on hepatic injury and provide a clue in understanding the role of B19 NS1 on hepatic injury in SLE.…”
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    Human Parvovirus B19 NS1 Protein Aggravates Liver Injury in NZB/W F1 Mice
  16. 12296
    “…CONCLUSION: GI symptoms, neurological symptoms and breathlessness are important clue to ED physician for diagnose methanol poisoning. …”
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    Study of various clinical and laboratory parameters among 178 patients affected by hooch tragedy in Ahmedabad, Gujarat (India): A single center experience
  17. 12297
    “…Although an altered pattern of α-dystroglycan O-mannosylation, that is not significantly changing its overall glycosylation fraction, represents the primary molecular clue behind currently known dystroglycanopathies, it cannot be ruled out that still unidentified forms of αDG-related dystrophy might originate by a more substantial reduction of α-dystroglycan glycosylation and by its consequent destabilization.…”
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    Probing the stability of the “naked” mucin-like domain of human α-dystroglycan
  18. 12298
    “…CONCLUSIONS: We demonstrated, using a murine ischemia model, that the EPC-CFA could be a useful way to investigate the differentiation levels of murine EPCs, further providing a crucial clue that large-EPC-CFU status may be more functional or effective EPCs to promote neovascularization.…”
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    Identification of mouse colony-forming endothelial progenitor cells for postnatal neovascularization: a novel insight highlighted by new mouse colony-forming assay
  19. 12299
    “…To the best of our knowledge, this is the first study to explore the role of RLRs in controlling the survival of MSCs, which may provide a clue to understand the pathogenesis of viral infection in MSCs.…”
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    Functional RIG-I-like receptors control the survival of mesenchymal stem cells
  20. 12300
    “…Partial response of this patient to cetirizine hydrochloride may grant us a new clue to understanding this mysterious condition.…”
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    An Egyptian child with erythromelalgia responding to a new line of treatment: a case report and review of the literature
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