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  1. 12401
    “…Validation included functional annotation based on biological processes and pathways using the ClueGO plug-in of Cytoscape. Hierarchical clustering and principal component analysis were performed using the ClustVis tool. …”
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    Label-Free Proteomics of Oral Mucosa Tissue to Identify Potential Biomarkers That Can Flag Predilection of Precancerous Lesions to Oral Cell Carcinoma: A Preliminary Study
  2. 12402
    “…CONCLUSIONS: PD-L1+ , CD8+ or FOXP3+ immune cells in the tumor microenvironment (TME) at both primary and metastatic sites are significant on prognosis, which could be a clue to expect the potential for better responses to the combination of chemotherapy and ICI, especially for patients with ALNM.…”
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    Programmed death ligand 1-positive immune cells in primary tumor or metastatic axillary lymph nodes can predict prognosis of triple-negative breast cancer even when present at < 1% in the tumor region
  3. 12403
    por Su, Kai, Gao, Yibo, He, Jie
    Publicado 2023
    “…Moreover, we found an inverse relationship between BMI and alpha diversity in these tissues, providing a new clue for deciphering the mechanisms of lung carcinogenesis.…”
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    A comparison of the microbiome composition in lower respiratory tract at different sites in early lung cancer patients
  4. 12404
    “…The present study aimed to screen ferroptosis genes associated with asthma and find therapeutic targets, in order to contribute a new clue for the diagnosis and therapy of asthma. METHODS: Ferroptosis-related differentially expressed genes (FR-DEGs) in asthma were selected by the GSE41861, GSE43696 and ferroptosis datasets. …”
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    Exploration and Validation of Potential Biomarkers and Therapeutic Targets in Ferroptosis of Asthma
  5. 12405
    “…The association of genetic profiles with PD-L1 expression levels also provide the clue that genomic phenotype may interact with the immunologic phenotype in ESCC.…”
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    Molecular profiles of different PD-L1 expression in patients with esophageal squamous cell carcinoma
  6. 12406
    “…CONCLUSION: After the booster vaccination, the NT50 and the neutralization ability of vaccine-induced antibodies increased, but the susceptibility of antibodies decreased compared with the control virus, which may be a clue for future Omicron sublineages prevention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12985-023-01977-5.…”
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    Immune escape of SARS-CoV-2 variants to therapeutic monoclonal antibodies: a system review and meta-analysis
  7. 12407
    “…We performed Gene Ontology (GO), Kyoto Encyclopedia of the Genome (KEGG), ClueGO, and Protein-Protein Interaction (PPI) analysis for DEFRGs and DEPRGs and validated them by machine learning. …”
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    Quercetin is a Potential Therapy for Rheumatoid Arthritis via Targeting Caspase-8 Through Ferroptosis and Pyroptosis
  8. 12408
    “…LESSONS: This is the first report of (18)F-FDG PET/CT application providing a clue for GD diagnosis. A novel mutation in GBA is described, which implies a potential pool of patients with GD with this mutation in Japan.…”
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    A novel mutation causing type 1 Gaucher disease found in a Japanese patient with gastric cancer: A case report
  9. 12409
    “…Our present data offer a clue for the development of new immunotherapeutic strategies capable of restoring the NK-mediated anti-tumor responses in association with the CRS/HIPEC treatment to increase the effectiveness of the current therapy.…”
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    Different Features of Tumor-Associated NK Cells in Patients With Low-Grade or High-Grade Peritoneal Carcinomatosis
  10. 12410
    “…CONCLUSION: The NLR could be a viable clue for distinguishing between PsPD and TPD. Patients with a high post-treatment NLR in this study all had TPD, suggesting that these subjects should be considered for an early transition to the next drug treatment regimen.…”
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    Pseudo-Progression and the Neutrophil-to-Lymphocyte Ratio in Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors: A Case–Control Study
  11. 12411
    “…This study also suggests a novel clue that STIM1 in skeletal muscle could be related to mitochondria via regulating intra and extracellular Ca(2+) movements.…”
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    A muscular hypotonia-associated STIM1 mutant at R429 induces abnormalities in intracellular Ca(2+) movement and extracellular Ca(2+) entry in skeletal muscle
  12. 12412
    “…Our findings revealed the rough profile of circulating sclerostin level in general healthy Chinese population and its associations with bone metabolism markers and sex hormones, which may provide a clue to further elucidate the cross action of sclerostin in bone metabolism and sexual development.…”
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    Sclerostin and Its Associations With Bone Metabolism Markers and Sex Hormones in Healthy Community-Dwelling Elderly Individuals and Adolescents
  13. 12413
    “…Family history of FMR1 gene associated diseases might be an important clue to the diagnosis.…”
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    A Chinese case of fragile X-associated tremor/ataxia syndrome (FXTAS) with orthostatic tremor:case report and literature review on tremor in FXTAS
  14. 12414
    “…CONCLUSIONS: Lipid plays a partial mediation on the association between smoking and CAD risk. The study provides a clue on the mediation effect of lipids on the relationship between smoking and CAD risks, which is a novel insight to the progression of CAD.…”
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    Mediating effects of lipids on the association between smoking and coronary artery disease risk among Chinese
  15. 12415
    “…An increase in the CD4/CD8 ratio may be a critical clue of drug resistance in ATB. Although the factors influencing CD4 and CD8 are not identical, our results indicated the importance of serum protein and platelets to ATB patients’ immune function. …”
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    Changes in T-lymphocyte subsets and risk factors in human immunodeficiency virus-negative patients with active tuberculosis
  16. 12416
    “…Taken together, our results suggest that the TRIM21/ANXA2/TFEB axis is involved in OS cell autophagy and subsequent differentiation, indicating that targeting this signaling axis might lead to a new clue for OS treatment.…”
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    TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy
  17. 12417
    por Zaki, Nazar, Mohamed, Elfadil A.
    Publicado 2021
    “…The disease has spread very swiftly worldwide. A timely clue which includes the estimation of the incubation period among COVID-19 patients can allow governments and healthcare authorities to act accordingly. …”
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    The estimations of the COVID-19 incubation period: A scoping reviews of the literature
  18. 12418
    “…Further gene ontology (GO) term and Kyoto Encyclopedia of Genomes (KEGG) pathway analyses were performed with plug-in ClueGO in Cytoscape software 3.7.0. Subsequently, the interaction regulatory network between encoded proteins of target genes was performed with the Search Tool for the Retrieval of Interacting Genes (STRING) database and analyzed using plug-in Molecular Complex Detection (MCODE) and cytoHubba in Cytoscape software 3.7.0. …”
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    Identification of potential serum exosomal microRNAs involved in acinar-ductal metaplasia that is a precursor of pancreatic cancer associated with chronic pancreatitis
  19. 12419
    “…This is another evident clue of fasciolosis. To the best of our knowledge, this is the first recent study that diagnosed fasciolosis in Chad. …”
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    Hepatic biomarkers and coprology as indicators of clinical bovine fasciolosis in Chad
  20. 12420
    “…This finding may prove a new clue to elucidate the pathogenetic mechanism of renal injury involved with CLL/SLL. …”
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    The pathological features of leukemic cells infiltrating the renal interstitium in chronic lymphocytic leukemia/small lymphocytic lymphoma from a large single Chinese center
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