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  1. 12421
    “…The scaling relationship between individual whole-shoot (i.e., aboveground parts) respiration and whole-shoot mass provides a clue for comparing the carbon budgets of Moso bamboo and tree forests. …”
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    Consistent scaling of whole-shoot respiration between Moso bamboo (Phyllostachys pubescens) and trees
  2. 12422
    “…PATIENTS AND METHODS: Original datasets GSE23117, GSE7451, and GSE127952 were obtained from the Gene Expression Omnibus database (GEO) and integrated and analyzed for differentially expressed genes in SS salivary glands. ClueGO and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of upregulated and downregulated DEGs were performed, and protein–protein interaction (PPI) networks were constructed using the STRING and Cytoscape database. …”
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    Bioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS
  3. 12423
    “…CONCLUSIONS: Taken together, our findings provided important clue for future study of the process of miRNA-regulation in IHH signaling and novel insights into the regulatory role of miRNA in pathogenesis of BDA1. …”
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    Altered microRNAs in C3H10T1/2 cells induced by p.E95K mutant IHH signaling
  4. 12424
    “…We intend to study the protein interaction through the protein interaction network in order to find a new clue for the management of patients with diabetes with COVID-19. …”
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    Interrelationship between 2019-nCov receptor DPP4 and diabetes mellitus targets based on protein interaction network
  5. 12425
    “…The discovery of the primary lesion is an important clue for the reliable diagnosis in such cases.…”
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    Cholangiocarcinoma presenting as dysphagia and misdiagnosed as gastritis: a case report
  6. 12426
    “…BACKGROUND: The plasticity of T helper-17 (Th17) and regulatory T (Treg) cells may be a clue to pathogenesis of Juvenile Idiopathic Arthritis (JIA). …”
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    Mitigated suppressive function of regulatory T cells (Treg) upon Th17-inducing cytokines in oligo- and polyarticular Juvenile Idiopathic Arthritis (JIA) patients
  7. 12427
    “…The interaction between selected genes was assessed using ClueGO, to identify the susceptible gene loci for SARS-CoV infections. …”
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    Pharmacogenomics deliberations of 2-deoxy-d-glucose in the treatment of COVID-19 disease: an in silico approach
  8. 12428
    “…We aimed to evaluate the influence of BPV as a risk factor for cryptogenic stroke and highlight the importance of including the (APBM) in the workup for those patients and test the relation between BPV and LA remodeling in these patients, which could be used as a clue to add APM monitoring to their workup. Also, LA remodeling may be a substrate for occult atrial fibrillation (AF). …”
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    The blood pressure variability in patients with cryptogenic stroke
  9. 12429
    “…This study elucidates the key indicators used to reflect the current function or potential of lymphocytes, which may provide a valuable clue for how to keep immunity healthy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12979-022-00298-5.…”
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    The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China
  10. 12430
    “…Here, we integrate available fundamental data and present a novel, open access, data-aggregating, drug repurposing platform, deriving our searches from the entries of Clue.io. We show how we integrated our previous expertise in small-cell lung cancer (SCLC) to initiate a new platform to overcome highly progressive cancers such as triple-negative breast and pancreatic cancer with data-aggregating approaches. …”
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    EZCancerTarget: an open-access drug repurposing and data-collection tool to enhance target validation and optimize international research efforts against highly progressive cancers
  11. 12431
    “…Our comprehensive analyses provide novel insights into SCLC pathogenesis and a clue to understanding subtype‐dependent phenotypic differences.…”
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    ASCL1 regulates super‐enhancer‐associated miRNAs to define molecular subtypes of small cell lung cancer
  12. 12432
    “…The correlation between HB-EGF expression and cancer-immune infiltrated cells was investigated by performing TIMER and ClueGo pathways analysis from TCGA database. The chemotaxis of HB-EGF and macrophage infiltration was investigated using migration and immunohistochemical staining. …”
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    Heparin binding epidermal growth factor–like growth factor is a prognostic marker correlated with levels of macrophages infiltrated in lung adenocarcinoma
  13. 12433
    “…The ontogenetic switch of hosts is high for species with enough data, which is another potential clue supporting the ecological hypothesis. Other results suggest that the networks displaying tick-host associations are different according to the biogeographical realms. …”
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    Worldwide host associations of the tick genus Ixodes suggest relationships based on environmental sharing rather than on co-phylogenetic events
  14. 12434
    “…Biological pathways enriched by these proteins were identified using ClueGo pathway analyses. RESULTS: The resulting digitised proteomic maps inclusive of 626 proteins were investigated in tandem with available clinical data to identify biomarkers of progression. …”
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    Proteomic signature associated with chronic kidney disease (CKD) progression identified by data-independent acquisition mass spectrometry
  15. 12435
    “…Taken together, our results suggest that irinotecan induces liver injury by orchestrating autophagy via HIF-1α/BNIP3 pathway, and HIF-1α inhibition could alleviate irinotecan-induced lipid accumulation in HepG2 and L-02 cells, which will provide a new clue and direction for the prevention of side effects of clinical chemotherapy drugs.…”
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    Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury
  16. 12436
    “…Their potential roles in the immune microenvironment of the small intestinal mucosa may provide a vital clue to IBS precision therapy.…”
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    Downregulated APOD and FCGR2A correlates with immune infiltration and lipid-induced symptoms of irritable bowel syndrome
  17. 12437
    “…CONCLUSION: Allergen-induced dendritic cell pyroptosis promotes the development of allergic rhinitis through GSDMD-N-mediated pyroptosis, which provides a clue to allergic disease interventions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01309-8.…”
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    Allergen-induced CD11c + dendritic cell pyroptosis aggravates allergic rhinitis
  18. 12438
    “…CONCLUSIONS: This study suggests the first clue that the relationship between air pollution exposure and thyroid hormone differs according to abdominal fat distribution among Korean adult males.…”
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    Effects of the abdominal fat distribution on the relationship between exposure to air pollutants and thyroid hormones among Korean adult males
  19. 12439
    “…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed in WebGestalt online and verified according to ClueGo and Pedia apps in Cytoscape. Then, the protein-protein interaction network was analyzed using the STRING database and constructed using Cytoscape. …”
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    Anti-atherosclerotic effects of naringenin and quercetin from Folium Artemisiae argyi by attenuating Interleukin-1 beta (IL-1β)/ matrix metalloproteinase 9 (MMP9): network pharmacology-based analysis and validation
  20. 12440
    por Li, Dawei, Wei, Yongchang, Zhu, Rongsheng
    Publicado 2023
    “…This study not only helps to further improve the accuracy of point cloud deep learning networks for crop organ segmentation, but also gives clue to the alignment of down-sampling strategies and a specific network.…”
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    A comparative study on point cloud down-sampling strategies for deep learning-based crop organ segmentation
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