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  1. 12481
    “…IMPORTANCE The genome sequence of bacterial pathogens commonly provides a detailed clue of genetic communication among clones or even distinct species. …”
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    Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae
  2. 12482
    “…This ascertainment of LPP-induced changes in the physiology of macrophages provides an important clue in the understanding of the mechanisms of bone disintegration, opening novel avenues to manage the course of S. aureus disease.…”
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    Bacterial Lipoproteins Shift Cellular Metabolism to Glycolysis in Macrophages Causing Bone Erosion
  3. 12483
    “…CONCLUSION: The m(6)A signature had a prominent capacity to evaluate OS and characterize the tumor immune microenvironment of HCC, which may serve as a useful approach for risk stratification management and provide a valuable clue to choosing rational therapeutic strategies.…”
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    The m(6)A-related gene signature stratifies poor prognosis patients and characterizes immunosuppressive microenvironment in hepatocellular carcinoma
  4. 12484
    “…BACKGROUND: The tissue expression pattern of a gene often provides an important clue to its potential role in a biological process. …”
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    Too much data, but little inter-changeability: a lesson learned from mining public data on tissue specificity of gene expression
  5. 12485
    “…TG-induced SOCE strongly potentiated I(Cl(Ca)), but abolished I(Cl, swell), thereby providing a clue for this paradox. Thus, we have established for the first time using a keratinocyte model that I(Cl, swell) can be physiologically activated under isotonic conditions by receptors coupled to the phosphoinositide pathway. …”
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    Ca(2+)- and Volume-sensitive Chloride Currents Are Differentially Regulated by Agonists and Store-operated Ca(2+) Entry
  6. 12486
    “…Curcumin decreased D-lactate release by tumor cells, another clue for inhibition of intracellular Glo1. CONCLUSIONS/SIGNIFICANCE: The results described herein provide new insights into curcumin's biological activities as they indicate that inhibition of Glo1 by curcumin may result in non-tolerable levels of MGO and GSH, which, in turn, modulate various metabolic cellular pathways including depletion of cellular ATP and GSH content. …”
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    Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity
  7. 12487
    por Zuo, Lian, Li, Wei, You, Shaojin
    Publicado 2010
    “…This novel finding may have great impact on fully understanding the pathogenesis of BPBC and provide an essential clue for developing a targeted therapeutic strategy for treatment of BPBC.…”
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    Progesterone reverses the mesenchymal phenotypes of basal phenotype breast cancer cells via a membrane progesterone receptor mediated pathway
  8. 12488
    “…CellDetect(® )provided a uniquely useful tinctorial clue for the detection of neoplasia, which exhibited an impressive 0% false negative rate. …”
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    Novel dual-function CellDetect(® )staining technology: wedding morphology and tinctorial discrimination to detect cervical neoplasia
  9. 12489
    “…Multivessel coronary disease or peripheral arterial disease is the clinical clue to diagnosis of renal artery stenosis (RAS). …”
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    The incidence of renal artery stenosis in the patients referred for coronary artery bypass grafting
  10. 12490
    “…However, the exact mechanism remains largely unknown. An important clue comes from recent studies linking autophagy with the onset of senescence. …”
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    Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
  11. 12491
    “…Severe pain out of proportion to physical findings is another clue. CONCLUSIONS: Haematologic malignancies must be excluded before initiation of therapy for childhood arthritis among children presenting with musculoskeletal signs and symptoms, particularly in atypical cases. …”
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    Rheumatic symptoms in childhood leukaemia and lymphoma-a ten-year retrospective study
  12. 12492
    “…HBeAg testing might provide clue for early treatment initiation. Furthermore, HBeAg negative patients are also associated with high HBV DNA levels and therefore require appropriate medical attention. …”
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    Characterization of Treatment-Naive HIV/HBV Co-Infected Patients Attending ART Clinic of a Tertiary Healthcare Centre in Eastern India
  13. 12493
    “…Although the efficacy of bosentan for dermal and pulmonary fibrosis is limited in SSc, the present observation definitely provides us with a useful clue to further explore the potential of the upcoming new dual endothelin receptor antagonists as disease modifying drugs for SSc.…”
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    Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1
  14. 12494
    “…Protein functions were classified by the GO biological process (ClueGO v2.0.7+Clupedia v1.0.8) and protein-protein interaction networks were constructed (PSICQUIC, Cytoscape). …”
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    Proteomic Analysis of Gastrocnemius Muscle in Rats with Streptozotocin-Induced Diabetes and Chronically Exposed to Fluoride
  15. 12495
    “…We also used WebGestalt, a web-based enrichment tool for the functional annotation and pathway analysis of the differentially synthesized proteins, using the Wikipathways database. ClueGO, a Cytoscape plug-in, is also used to compare groups of proteins and to visualize the functionally organized Gene Ontology (GO) terms and pathways in the form of dynamical network structures. …”
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    Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis
  16. 12496
    “…In such cases, slight pancreatic duct dilation may be a diagnostic clue.…”
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    Pancreatic cancer accompanied by a moderate-sized pseudocyst with extrapancreatic growth
  17. 12497
    “…The elevated hsCRP levels and their correlation to hemostatic factors and CIMT might provide an important clue to link a systemic marker of inflammation to atherosclerosis. …”
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    The Role of Hemostatic Factors in Atherosclerosis in Patients with Chronic Renal Disease
  18. 12498
    por Mira, Amira, Shimizu, Kuniyoshi
    Publicado 2015
    “…SUMMARY: The present study provides for the first time a clue for the cytotoxic activities of the AME. Our results indicate that the cytotoxic activities are partially related to the ability of AME to inhibit tubulin polymerization and HDAC8 activity. …”
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    In vitro Cytotoxic Activities and Molecular Mechanisms of Angelica shikokiana Extract and its Isolated Compounds
  19. 12499
    “…CONCLUSION: These findings suggest that nasal septal surgery has a positive effect on pulmonary functions, and this can be an important clue for the relationship of lung disorders and nasal obstruction.…”
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    Improvement of Pulmonary Functions Following Septoplasty: How Are Lower Airways Affected?
  20. 12500
    por Han, Xu, Kim, Jung-jae, Kwoh, Chee Keong
    Publicado 2016
    “…They also did not consider the evidence of event participants, which might be a clue for the presence of events in unlabeled documents. …”
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    Active learning for ontological event extraction incorporating named entity recognition and unknown word handling
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