“…Their reduced GnRHR proteins and normal Gnrhr mRNA levels suggest leptin’s actions on gonadotropes are post-transcriptional. A clue about a candidate translational regulator is seen in our studies showing that Lepr-null gonadotropes have increased expression of Musashi (MSI), which has binding sites within the Gnrhr 3’ UTR. …”
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“…Furthermore, we used the ClueGO software to decipher the pathways network and reveal the biological functions of target genes of miRNAs. …”
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“…Elevated T4 and T3 with non-suppressed TSH concentration is the main diagnostic clue for this disease. Mutation analysis allows definitive diagnosis of RTHβ and may help to avoid potential misdiagnosis and improper treatment.…”
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“…A suppressed DHEA-S level, as seen in our patient, may provide the clue to exogenous GC use as the cause of CS. Our case is also rare because our patient is male, older, and not related to the medical field. …”
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“…Reduced mGluR(5) expression throughout the living brains of men with FXS provides a clue to examine FMRP and mGluR(5) expression in FXS. …”
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“…This situation give a clue that numbers of people having fear and panic of infection is more than sufferer of actual pandemic due to covid infection.During years 2019,2020,2021 pandemic and post covid pandemic periods , there were sudden raising pattern is seen in the psychological disorder noted worldwide as per the panelists of different organization and private research analysts. …”
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“…METHODS: In the current study, a network analysis approach integrating active compound screening (drug-likeness, lipophilicity, and aqueous solubility models), target fishing (Traditional Chinese Medicine Systems Pharmacology, fingerprint-based Similarity Ensemble Approach, and PharmMapper databases), compound-target-disease network construction (Cytoscape software), protein-protein interaction network construction (STRING and Cytoscape software), biological process analysis (STRING and Cytoscape plug-in Clue GO) and pathway analysis (Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis) was developed to decipher the active ingredients, potential targets, relevant pathways, and the therapeutic mechanisms of SFI for preventing and treating COVID-19 combined with HF. …”
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“…Our findings provide a clue to elucidate the function of ucOC in bone metabolism.…”
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“…FRGs expression was analyzed by Gene Set Expression Analysis (GSEA), and FDEGs were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) pathway enrichment analyses using the clusterProfiler package in R and ClueGO in Cytoscape. Protein–protein interaction networks were assembled using Cytoscape, and crucial FDEGs were identified using CytoHubba. …”
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“…These results provided potential insights into understanding the relationship of coexistence between plasmids encoding antibiotic resistance and their bacterial hosts and provided a clue to the adaptive forces that shaped the evolution of these plasmids within bacteria and to predicting the evolution trajectory of antibiotic resistance.…”
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“…Firstly, although not immediately noted, incisional thyroid biopsy was the first diagnostic clue of sarcoidosis. More commonly, patients are already diagnosed with systemic sarcoidosis. …”
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“…The Co-genes were evaluated by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and ClueGO for functional enrichment, the protein-protein interaction (PPI) network was built by STRING, and the k-means machine learning algorithm was employed for cluster analysis. …”
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“…Pathological metabolic changes of excitatory/inhibitory neurotransmitters and abnormal protein deposition in the hippocampus of aMCI may provide a new clue to imaging diagnosis. However, the diagnostic performance using these hippocampal metabolite measurements is still unclear. …”
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“…Imaging of the contralateral adrenal gland provides a valuable clue in making the diagnosis of ectopic ACTH production (as the gland is enlarged rather than atrophic). …”
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“…In view of this, this paper attempts to take Jingdong farm as a typical case, take its development process as a clue, answer the dynamic evolution mechanism of smart agriculture, and then put forward the overall framework of the transformation and upgrading from traditional agriculture to smart agriculture. …”
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“…A persistently low ALP is most suggestive and may be a clue for early referral. Genetic testing is confirmatory, but novel mutations may be missed. …”
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“…CONCLUSION: Monitoring the kinetics of lymphocyte subpopulations especially activatory NK cells before and after RCT might provide a clue with respect to the development of an early locoregional recurrence in patients with SCCHN. …”
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“…Rhabdoid cells can be a helpful morphological clue for promoting molecular and immunohistochemical analyses for deficiency of SWI/SNF subunits, in the diagnostic workup of undifferentiated neoplasms featuring epithelioid or rhabdoid morphology. …”
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“…Although our case mimicked a dumbbell shaped neurogenic tumor, its midline location and destructive pattern were characteristic feature indicating a clue to the diagnosis of chordoma that was already confirmed with histopathology. …”
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