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  1. 1681
    por Matthews, L. C., Hanley, N. A.
    Publicado 2010
    “…There are now substantial data indicating that glucocorticoids mediate this effect of under-nutrition on beta cell mass and that even at physiological levels they restrain fetal beta cell development in utero. There are emerging clues that this occurs downstream of endocrine commitment by neurogenin 3 but prior to terminal beta cell differentiation. …”
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    The stress of starvation: glucocorticoid restraint of beta cell development
  2. 1682
    “…Clinical experience and available clues on optimal management are also discussed.…”
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    Online Artículo Texto
    Thalassemia and Venous Thromboembolism
  3. 1683
    “…More cases must be accumulated and investigated to obtain clues for accurate diagnosis.…”
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    Solid variant of serous cystadenoma of the pancreas
  4. 1684
    por Gunaydin, Hakan, Gu, Yan, Huang, Xin
    Publicado 2012
    “…The TNKS1/IWR2 complex provides a molecular basis for their strong and specific interactions and suggests clues for further development of tankyrase inhibitors.…”
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    Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
  5. 1685
    por Otera, Hidenori, Mihara, Katsuyoshi
    Publicado 2012
    “…The discovery of large GTPase family proteins that regulate mitochondrial dynamics, together with novel insights into the role of mitochondrial fusion and fission in apoptosis, has provided important clues to understanding the molecular mechanisms of cellular apoptosis. …”
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    Mitochondrial Dynamics: Functional Link with Apoptosis
  6. 1686
    “…The aim of this article is to report the imaging characteristics of MO, the emphasis being on the early diagnostic clues. USG can be used at an early stage to reveal the ‘zone phenomenon,’ which is highly suggestive of MO. …”
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    Myositis ossificans imaging: keys to successful diagnosis
  7. 1687
    por Houssiau, Frédéric A
    Publicado 2012
    “…The review will address clues for optimal global care, such as the need for complete initial evaluation, the importance of patient education, the unmasking of non-compliance to therapy, the reason for an early treatment switch in non-responding patients, the need for prolonged immunosuppression, optimal renal protection, and prevention of cardiovascular disease and other comorbidities.…”
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    Therapy of lupus nephritis: lessons learned from clinical research and daily care of patients
  8. 1688
    “…In this mini-review, we discuss the close relationship between chondrocyte death including necrosis and loss of proteoglycan, and its potential mechanism during KBD onset and development, which may provide new clues for KBD research.…”
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    Proteoglycan metabolism, cell death and Kashin-Beck Disease
  9. 1689
    por Roy, S., Parwani, A. V.
    Publicado 2012
    “…The various differential diagnoses and use of morphological clues and immunohistochemistry are discussed.…”
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    Primary Renal Epithelioid Hemangioendothelioma
  10. 1690
    “…This discovery might provide clues as to the evolution of the NDVs of different avian origins.…”
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    Complete Genome Sequences of Newcastle Disease Virus Strains Isolated from Three Different Poultry Species in China
  11. 1691
    “…Inability to flex the interphalangeal joint of the thumb and absent dorsal wrinkles and flexion creases of the thumb are important clues to the diagnosis. Routine radiography and cross-sectional imaging help to confirm and document the condition. …”
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    Bilateral congenital absence of flexor pollicis longus with thumb hypoplasia and thenar atrophy
  12. 1692
    por Bae, Jong-Myon
    Publicado 2014
    “…Evaluating these hypotheses would require important clues to find unknown risk factors of breast cancer and to plan more effective strategies for breast cancer control in Korean women.…”
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    Two hypotheses of dense breasts and viral infection for explaining incidence of breast cancer by age group in Korean women
  13. 1693
    “…The recommendations presented below provide iron deficiency anaemia management clues in patients with inflammatory bowel disease.…”
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    Iron deficiency anaemia in patients with inflammatory bowel disease: National Consultant for Gastroenterology Working Group Recommendations
  14. 1694
    “…Enzymatic assay of these substrate analogs along with clues from the product profile of the native substrate strongly suggest that iridoid synthase utilizes a Michael reaction to achieve cyclization. …”
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    Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis
  15. 1695
    “…In this article we argue that an understanding of the differences between children who recover from asthma and those who do not would contribute to increased understanding of the pathogenic mechanisms of the disease and could provide new clues about prevention and treatment. We note that some researchers have recently published results from these kinds of investigations. …”
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    Have Recent Investigations into Remission from Childhood Asthma Helped in Understanding the Pathogenesis of this Disease?
  16. 1696
    “…A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing. …”
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    Interactome analysis brings splicing into focus
  17. 1697
    “…EDUCATIONAL VALUE: POLG mutation should be considered in patients with PAPT, particularly when additional clues such as a sensory neuronopathy or an ophthalmoplegia are present.…”
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    Progressive Ataxia and Palatal Tremor: Think about POLG Mutations
  18. 1698
    por Dong, Su-Zhen, Zhu, Ming
    Publicado 2016
    “…This pictorial review draws on our experience about fetal cardiac MRI; it describes the four-chamber view on fetal cardiac MRI and important clues on an abnormal four-chamber view to the diagnosis of fetal congenital cardiovascular anomalies.…”
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    MR imaging of fetal cardiac malposition and congenital cardiovascular anomalies on the four-chamber view
  19. 1699
    por Tang, Binhua
    Publicado 2016
    “…Benchmarked with T-47D cell, we interrogated the association within differentially methylated CpG (DMC) and region (DMR) candidate count and region length and identified major transition zones as clues for inferring statistically significant DMRs; together we validated those DMRs with the functional annotation. …”
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    META2: Intercellular DNA Methylation Pairwise Annotation and Integrative Analysis
  20. 1700
    “…We have gathered biological evidences giving possible clues to the development of the axenic (i.e. ‘cell-free’) growth of obligate parasites from various sources including published literature, genomic sequence information, metabolic databases and transporter databases. …”
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    Metagrowth: a new resource for the building of metabolic hypotheses in microbiology
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