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1921“…It also underlines the importance of activating mutations in the KRAS gene in relation to carcinogenesis and their importance as diagnostic biomarkers, providing clues regarding human cancer patients' prognosis and indicating potential therapeutic approaches.…”
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1922“…A recently published transcriptional oscillator associated with the yeast cell cycle provides clues and raises questions about the mechanisms underlying autonomous cyclic processes in cells. …”
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1923Tumor Microenvironment and Immune Effects of Antineoplastic Therapy in Lymphoproliferative Syndromespor Álvaro, Tomás, de la Cruz-Merino, Luis, Henao-Carrasco, Fernando, Villar Rodríguez, José Luis, Vicente Baz, David, Codes Manuel de Villena, Manuel, Provencio, Mariano“…Also, the state of the art of lymphoma's anti-idiotype vaccine development is revised, highlighting the situations where this strategy has proven to be successful and eventual clues to obtain better results in the future.…”
Publicado 2010
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1924por Musunuru, Kiran“…Achieving a better understanding of the genetic and dietary influences underlying atherogenic dyslipidemia may provide clues to improved interventions to reduce the risk of cardiovascular disease in high-risk individuals.…”
Publicado 2010
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1925“…Simulations show complex internal flows and motions of nutrients, metabolites and cells, that are otherwise unobservable with current experimental techniques, and give novel clues on tumor development and strong hints for future therapies.…”
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1926“…Understanding the molecular and cellular events during regenerative healing may provide clues that one day enable us to modulate adult wound healing and consequently reduce scarring.…”
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1927por Nakazawa, Mitsuru“…These achievements have provided clues to the mechanisms of photoreceptor degeneration in RP. …”
Publicado 2011
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1928“…Bearing little resemblance to other proteins, its function has been difficult to assign, therefore localising this protein with precision within the cell may provide further clues as to its normal and pathological function. …”
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1929“…The study of diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous mouse models of lupus have led to identification of numerous susceptibility loci from which several candidate genes have emerged. …”
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1930“…These data, combined with computer modelling and the previously published data on S15 binding and in vivo control, provide important clues on pseudoknot formation and S15 recognition. …”
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1931“…Indeed, a better understanding of these mechanisms should provide clues to the development of novel clinical therapies. …”
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1932“…This is not only confusing but also unhelpful in determining valid genotype-phenotype correlations, and thereby revealing clues for pathogenesis. We undertook a systematic review of the literature focusing on CCO as part of anterior segment developmental anomalies (ASDA), and analyzed its association specifically with chromosomal abnormalities. …”
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1933por Chakrabarti, Subho“…Neurotransmitter, neuroimaging, and genetic studies have begun to provide clues, which could lead to an improved understanding of the thyroid-bipolar disorder connection, and more optimal ways of managing this potentially disabling condition.…”
Publicado 2011
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1934“…Thus, discovery of novel specific biomarkers are needed that may provide informative clues for early diagnosis and treatment of cancer. …”
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1935“…In addition, our discrimination method yielded some clues for understanding the interaction patterns in several examples in the PDB. …”
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1936por Siever, Larry J.“…Thus, an endophenotypic approach not only provides clues to underlying candidate genes contributing to these behavioral dimensions, but may also point the way to a better understanding of pathophysiological mechanisms.…”
Publicado 2005
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1937por Runyon, Bruce Allen“…This paper provides the author's advice regarding clues to the presence of cirrhosis and the dos and do nots in the general care of these patients, based on his 30 years of experience in a liver-failure-focused academic practice.…”
Publicado 2011
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1938por Weiss, John H.“…This review summarizes some of the clues that have emerged over recent years to the contributions of these channels in disease.…”
Publicado 2011
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1939por Onur, Mehmet Ruhi, Yalnız, Mehmet, Poyraz, Ahmet Kursad, Özercan, Ibrahim Hanifi, Ozkan, Yusuf“…Decreased signal on T1-weighted images without inflammation findings on CT and MRI were clues for the diagnosis.…”
Publicado 2012
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1940por Takumi, Toru“…Further studies using these models will provide important clues to the pathophysiology of autism. This review overviews phenotypes of mouse models of genes in 15q11–q13 and their relationships to autism.…”
Publicado 2011
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