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  1. 2141
    “…When compared with standard systems, such as microtiter enzyme-linked immunosorbant assay, the method described here is dramatically faster and yields far more information about the interaction under study, allowing better characterization of complex systems. For example, in the case of fibronectin, it was possible to identify the specific domains involved in the interaction.…”
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    Rapid interactome profiling by massive sequencing
  2. 2142
    “…Our study showed that metabonomics could be effectively applied in clinical problems to show the overall correlation structure of complex systems in pathology. Specifically, our results confirmed the importance of TCD in the metabolic profiling and follow-up of migraine patients.…”
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    Joint Metabonomic and Instrumental Analysis for the Classification of Migraine Patients with 677-MTHFR Mutations
  3. 2143
    “…Our method is scalable and readily adaptable to studying complex systems, including cell proliferation, differentiation and apoptosis.…”
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    The living microarray: a high-throughput platform for measuring transcription dynamics in single cells
  4. 2144
    “…Modern science of networks has brought significant advances to our understanding of complex systems biology. As a representative model of systems biology, Protein Interaction Networks (PINs) are characterized by a remarkable modular structures, reflecting functional associations between their components. …”
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    BinTree Seeking: A Novel Approach to Mine Both Bi-Sparse and Cohesive Modules in Protein Interaction Networks
  5. 2145
    “…These coordinated research efforts, sponsored by the National Cancer Institute Integrative Cancer Biology Program (ICBP), brought together system scientists with expertise in engineering, mathematics, and complex systems theory and translational cancer researchers with expertise in radiation biology. …”
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    Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers
  6. 2146
    “…Further studies in more complex systems in vitro and in vivo are required. Nevertheless, these findings might open up a new therapeutic option for the treatment of oral mucositis.…”
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    Morphine Stimulates Cell Migration of Oral Epithelial Cells by Delta-Opioid Receptor Activation
  7. 2147
    “…Pattern-oriented modeling (POM) is a general strategy for modeling complex systems. In POM, multiple patterns observed at different scales and hierarchical levels are used to optimize model structure, to test and select sub-models of key processes, and for calibration. …”
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    Post-Hoc Pattern-Oriented Testing and Tuning of an Existing Large Model: Lessons from the Field Vole
  8. 2148
    “…Social insect colonies are complex systems in which the interactions of many individuals lead to colony-level collective behaviors such as foraging. …”
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    The Trail Less Traveled: Individual Decision-Making and Its Effect on Group Behavior
  9. 2149
    “…Our results suggest that defects in many signaling or metabolic pathways have a negative effect on AOX expression and imply that complex systems control production of the enzyme.…”
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    Identification of Genes Required for Alternative Oxidase Production in the Neurospora crassa Gene Knockout Library
  10. 2150
    “…By translating probabilistic dependencies among variables into graphical models and vice versa, BNs provide a comprehensible and modular framework for representing complex systems. We first describe the Bayesian network approach and its applicability to understanding the genetic and environmental basis of disease. …”
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    Using Bayesian networks to discover relations between genes, environment, and disease
  11. 2151
    por Thunhurst, Colin P
    Publicado 2013
    “…However, a parallel shift was taking place in the cognate field of operational research/systems analysis (OR/SA) which was adding greatly to our ability to analyse and to identify key points of intervention in complex systems. This led to the emergence of new techniques for problem structuring which overcame many of the limitations of formal mathematical models which characterised the old paradigm. …”
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    Public health systems analysis - where the River Kabul meets the River Indus
  12. 2152
    por Savit, Robert, Riolo, Maria, Riolo, Rick
    Publicado 2013
    “…We wish to understand which general features of complex systems necessarily follow from the (meta)-dynamics of co-adaptation, and which features depend on the details of particular systems. …”
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    Co-Adaptation and the Emergence of Structure
  13. 2153
    “…Among various collective properties, criticality is known as a characteristic property of a complex system, which helps the systems to respond flexibly to external perturbations. …”
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    Emergence of Criticality in the Transportation Passenger Flow: Scaling and Renormalization in the Seoul Bus System
  14. 2154
    “…The latter phenomenon is of particular interest because auditory cueing is generally considered to reduce stride variability and may hence be beneficial for stabilizing gait. Complex systems tend to match their correlation structure when synchronizing. …”
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    Persistent Fluctuations in Stride Intervals under Fractal Auditory Stimulation
  15. 2155
    “…The implications of our findings for detailed analyses of complex systems, including those that are transiently populated, are discussed.…”
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    Analysis of Amyloid Nanostructures Using Photo-cross-linking: In Situ Comparison of Three Widely Used Photo-cross-linkers
  16. 2156
    “…Biological agents are the most complex systems humans have to model and predict. In predictive coding, high-level cortical areas inform sensory cortex about incoming sensory signals, a comparison between the predicted and actual sensory feedback is made, and information about unpredicted sensory information is passed forward to higher-level areas. …”
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    Effective connectivity during animacy perception – dynamic causal modelling of Human Connectome Project data
  17. 2157
    “…Mapping a network morphospace reveals the extent to which the space is filled by existing networks, thus allowing a distinction between actual and impossible designs and highlighting the generative potential of rules and constraints that pervade the evolution of complex systems.…”
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    Network morphospace
  18. 2158
    “…METHODS AND RESULTS: Between 2008 and 2011, the Belgian development aid agency (BTC) launched a set of reforms in the Kisantu district, in the province of Bas Congo, through an action-research process deemed appropriate for the implementation of change within open complex systems such as the Kisantu local health system. …”
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    Improving financial access to health care in the Kisantu district in the Democratic Republic of Congo: acting upon complexity
  19. 2159
    “…Monitoring and control of primary cell cultures is challenging as they are heterogenous and dynamically complex systems. Feedback signaling proteins produced from off-target cell populations can accumulate, inhibiting the production of the desired cell populations. …”
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    Real-Time Monitoring and Control of Soluble Signaling Factors Enables Enhanced Progenitor Cell Outputs from Human Cord Blood Stem Cell Cultures
  20. 2160
    “…Existing methods for in vivo evaluations demand complex systems for laser heating and infrared thermography, or they require rigid, invasive probes; neither can apply to arbitrary regions of the body, offers modes for rapid spatial mapping, or enables continuous monitoring outside of laboratory settings. …”
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    Thermal Transport Characteristics of Human Skin Measured In Vivo Using Ultrathin Conformal Arrays of Thermal Sensors and Actuators
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