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  1. 2341
    “…This study demonstrates the utility of an appreciative inquiry approach for understanding how complex systems like medical education institutions are innovatively tackling challenges around health equity. …”
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    Exploring social accountability in Canadian medical schools: broader perspectives
  2. 2342
    “…Often complexity in structure and behaviour go together. (4) Complex systems admit many descriptions (ways of looking at the system) each of which is only partially true. …”
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    The complexity of anatomical systems
  3. 2343
    por Wegner, Katja, Kummer, Ursula
    Publicado 2005
    “…RESULTS: Out of these reasons we have developed a new algorithm which tackles these problems by reducing the number of edge crossings in complex systems, taking further biological conventions into account to identify and visualise cycles. …”
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    A new dynamical layout algorithm for complex biochemical reaction networks
  4. 2344
    “…Emerging principles of SV40 assembly may help understanding assembly of other complex systems. In addition, the SV40-based nanoparticles described here are potential gene therapy vectors that combine efficient gene delivery with safety and flexibility.…”
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    High Cooperativity of the SV40 Major Capsid Protein VP1 in Virus Assembly
  5. 2345
    “…The possibility of using computer simulation and mathematical modeling to gain insight into biological and other complex systems is receiving increased attention. However, it is as yet unclear to what extent these techniques will provide useful biological insights or even what the best approach is. …”
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    A Virtual Look at Epstein–Barr Virus Infection: Biological Interpretations
  6. 2346
    por Nacher, Jose C, Schwartz, Jean-Marc
    Publicado 2008
    “…BACKGROUND: Network science is already making an impact on the study of complex systems and offers a promising variety of tools to understand their formation and evolution in many disparate fields from technological networks to biological systems. …”
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    A global view of drug-therapy interactions
  7. 2347
    “…CONCLUSION: The data suggest that a comparative transcriptomics and metabolomics approach can be used to identify the metabolic impacts of the expression of individual genes in complex systems, and the amenability of transcriptomic data to direct applications of biotechnological relevance.…”
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    Linking gene regulation and the exo-metabolome: A comparative transcriptomics approach to identify genes that impact on the production of volatile aroma compounds in yeast
  8. 2348
    “…These results have implications for the evolutionary significance of global network topologies, which are known to be conserved across disparate complex systems.…”
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    Natural selection governs local, but not global, evolutionary gene coexpression networks in Caenorhabditis elegans
  9. 2349
    “…Such modeling systems are particularly relevant for the study of complex systems, like the epidemiology of emerging infectious diseases. …”
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    Multi-agent systems in epidemiology: a first step for computational biology in the study of vector-borne disease transmission
  10. 2350
    “…BACKGROUND: Signalling pathways are complex systems in which not only simple monomeric molecules interact, but also more complex structures that include constitutive or induced protein assemblies. …”
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    Dynamics of receptor and protein transducer homodimerisation
  11. 2351
    “…This encourages future work to establish the reasons underpinning these spectral differences and to move forward to more complex systems involving tissues. We have also shown that the use of sophisticated mathematical modelling allows a high degree of discrimination of 'raw' spectral data.…”
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    Raman spectroscopy and advanced mathematical modelling in the discrimination of human thyroid cell lines
  12. 2352
    “…The idea that complex systems have a hierarchical modular organization originated in the early 1960s and has recently attracted fresh support from quantitative studies of large scale, real-life networks. …”
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    Hierarchical Modularity in Human Brain Functional Networks
  13. 2353
    “…Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes' and ‘edges', respectively. …”
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    Edgetic perturbation models of human inherited disorders
  14. 2354
    “…This research reinforces the idea that computational modelling can be an effective additional tool to aid our understanding of complex systems. In the accompanying paper the model is used to explore hypotheses of the functions of TGF-β1 at the cellular and subcellular level on different keratinocyte populations during epidermal wound healing.…”
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    Development of a Three Dimensional Multiscale Computational Model of the Human Epidermis
  15. 2355
    “…However, development of these complex systems is only partially understood. Zebrafish provide an excellent model for genetic analysis of neuronal specification and axonal projections in vertebrates. …”
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    Genetic dissection of dopaminergic and noradrenergic contributions to catecholaminergic tracts in early larval zebrafish
  16. 2356
    por Artzy-Randrup, Yael, Stone, Lewi
    Publicado 2010
    “…In particular, while theoretical arguments have, in the past, suggested that increasing connectivity is a destabilizing feature in complex systems, this is not evident in metapopulation networks where connectivity, cycles, coherency, and heterogeneity all tend to enhance persistence. …”
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    Connectivity, Cycles, and Persistence Thresholds in Metapopulation Networks
  17. 2357
    “…Both functional molecular ecological networks under eCO(2) and ambient CO(2) (aCO(2)) possessed the general characteristics of complex systems such as scale free, small world, modular, and hierarchical. …”
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    Functional Molecular Ecological Networks
  18. 2358
    por Grossi, Enzo
    Publicado 2010
    “…The coupling of computer science and these new theoretical bases coming from complex systems mathematics allows the creation of “intelligent” agents able to adapt themselves dynamically to problem of high complexity: the Artificial Adaptive Systems, which include Artificial Neural Networks( ANNs ) and Evolutionary Algorithms ( EA). …”
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    Artificial Adaptive Systems and predictive medicine: a revolutionary paradigm shift
  19. 2359
    “…These complex responses to cellular signaling and transport machinery were similar to emergent behaviors in other complex systems, suggesting that even within a complex embryonic tissue, the overall system can converge toward a predictive first-order response.…”
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    Detection of Dynamic Spatiotemporal Response to Periodic Chemical Stimulation in a Xenopus Embryonic Tissue
  20. 2360
    “…Knowledge of phenotype networks describing such interrelationships can be used to predict the behavior of complex systems, e.g. biological pathways underlying complex traits such as diseases, growth and reproduction. …”
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    Inferring causal phenotype networks using structural equation models
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