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  1. 2401
    “…To understand the ethical implications of reluctance to treat there is a need to recognise the constraints of doctors working in complex systems and to consider how these constraints may influence reluctance. …”
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    Is clinician refusal to treat an emerging problem in injury compensation systems?
  2. 2402
    “…BACKGROUND AND MOTIVATIONS: Module identification has been studied extensively in order to gain deeper understanding of complex systems, such as social networks as well as biological networks. …”
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    Bayesian module identification from multiple noisy networks
  3. 2403
    “…Bacteria with two cell membranes (diderms) have evolved complex systems for protein secretion. These systems were extensively studied in some model bacteria, but the characterisation of their diversity has lagged behind due to lack of standard annotation tools. …”
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    Identification of protein secretion systems in bacterial genomes
  4. 2404
    por Chin, Jia Hou, Ratnavelu, Kuru
    Publicado 2016
    “…Community structure is considered one of the most interesting features in complex networks. Many real-world complex systems exhibit community structure, where individuals with similar properties form a community. …”
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    Detecting Community Structure by Using a Constrained Label Propagation Algorithm
  5. 2405
    “…They serve as dynamic regulators of CNS physiology and pathophysiology, and facilitate rapid and long-lasting changes to complex systems and behaviors. MiRNAs function in glucocorticoid signaling and the mesolimbic dopamine reward system, as well as mood disorders related to drug withdrawal. …”
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    MicroRNAs Modulate Interactions between Stress and Risk for Cocaine Addiction
  6. 2406
    “…Thus, the ability to predict and ultimately tune these complex systems to specific applications, both current and future, demands not just parametrization at the bulk scale but rather specific experimentation and understanding over multiple length scales within the same battery system, from the molecular scale to the mesoscale. …”
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    Investigating the Complex Chemistry of Functional Energy Storage Systems: The Need for an Integrative, Multiscale (Molecular to Mesoscale) Perspective
  7. 2407
    “…Equally important, this method can be applied to other complex systems even containing f elements and other molecular dimers such as S(2), N(2), B(2) and Si(2), where the complex orbital orientations require extensive search for finding the optimal orientations to maximize the bonding with the dimers, predicting new 2D materials beyond MXenes (a family of transition metal carbides or nitrides) and dichalcogenide monolayers.…”
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    Bonding-restricted structure search for novel 2D materials with dispersed C(2) dimers
  8. 2408
    “…Our image-based approach provides a deeper insight into the cellular dynamics and heterogeneity of tumors (or other complex systems), with reduced reagents and time, offering advantages over traditional biological assays.…”
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    A high-content image-based method for quantitatively studying context-dependent cell population dynamics
  9. 2409
    por Chen, Pei, Li, Yongjun
    Publicado 2016
    “…As validation, this approach is applied to detect the upcoming critical transition of complex systems based on both the dataset generated from a simulated network and the rich information provided by high-throughput microarray data. …”
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    The decrease of consistence probability: at the crossroad of catastrophic transition of a biological system
  10. 2410
    “…This measure represents an important tool in complex systems research because it allows for the quantification of the complexity of a neural system. …”
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    Criticality Maximizes Complexity in Neural Tissue
  11. 2411
    “…These results demonstrate the utility of MiPACT-HCR to directly capture the spatial organization and metabolic activity of bacteria in complex systems, such as human sputum.…”
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    Exposing the Three-Dimensional Biogeography and Metabolic States of Pathogens in Cystic Fibrosis Sputum via Hydrogel Embedding, Clearing, and rRNA Labeling
  12. 2412
    “…The peptides are detected using multiple reaction monitoring (MRM) mass spectrometry, a highly specific technique that enables peptide-based species determination even in complex systems. In addition, the ratio of MRM peak areas deriving from corresponding peptides supports relative quantitation. …”
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    Species Determination and Quantitation in Mixtures Using MRM Mass Spectrometry of Peptides Applied to Meat Authentication
  13. 2413
    por Kim, Ye Eun, Higgs, Paul G.
    Publicado 2016
    “…We therefore speculate that linkage of genes onto mini-chromosomes and encapsulation of strands in protocells would have been important fairly early in the history of life as a means of enabling more complex systems to evolve.…”
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    Co-operation between Polymerases and Nucleotide Synthetases in the RNA World
  14. 2414
    “…The general SEM framework in strum is very useful to model and test for the association with massive genotype data and complex systems of multiple phenotypes with general pedigree data.…”
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    Structural equation modeling with latent variables for longitudinal blood pressure traits using general pedigrees
  15. 2415
    “…Microservice architecture is a framework for dividing complex systems into easily managed parts. Each individual service is limited in functional scope, thereby conferring a higher measure of functional isolation and reliability to the collective solution. …”
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    The growing need for microservices in bioinformatics
  16. 2416
    “…In view of the molecular modelling, binding of the five inhibitors to the conserved loop region (Val372, Leu460, and Tyr461) of the cholesterol binding sites led to stable complex systems, which was consistent with the result of β-sitosterol. …”
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    Insights into structure and activity of natural compound inhibitors of pneumolysin
  17. 2417
    “…BACKGROUND: Pastoral social-ecological systems (SESs) are adaptive and complex systems rooted in the extensive exploitation of forage plants for livestock-based livelihoods and culture. …”
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    The role of Nucularia perrinii Batt. (Chenopodiaceae) in the camel-based Sahrawi social-ecological system
  18. 2418
    “…Application of 3D printing allowed assembling more complex systems, including the bianisotropic system with optimal microhelices, which showed an extreme polarization azimuth rotation of 85° with drop by 150° at a frequency shift of 0.4%. …”
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    Terahertz metamaterials and systems based on rolled-up 3D elements: designs, technological approaches, and properties
  19. 2419
    “…Finally, PC-corr is a general functional network inference approach that can be easily adopted for big data exploration in computer science and analysis of complex systems in physics.…”
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    Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies
  20. 2420
    “…Some approaches are explicitly based on mathematical models which investigate the synchronization between weakly coupled complex systems. Others use an heuristic approach, i.e. characteristic features of both time series, to develop appropriate bivariate methods. …”
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    A quantitative comparison of different methods to detect cardiorespiratory coordination during night-time sleep
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