“…An attractor, in complex systems theory, is any state that is more easily or more often entered or acquired than departed or lost; attractor states therefore accumulate more members than non-attractors, other things being equal. …”
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“…Complex networks have been successfully applied to the characterization and modeling of complex systems in several distinct areas of Biological Sciences. …”
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“…There is growing interest in the use of critical slowing down and critical fluctuations as early warning signals for critical transitions in different complex systems. However, while some studies found them effective, others found the opposite. …”
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“…Related to this is the need for a systemic and dynamic conception of interventions that raises the question of delineating the scope and contours of interventions in complex systems. This means identifying which elements belong to the intervention (and therefore participate in its effects and can be transferred), which ones belong to the context and interact with the former to influence results (and therefore must be taken into account when transferring the intervention) and which contextual elements are irrelevant to the intervention. …”
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“…Many neurological and psychiatric disorders involve complex, systems-level alterations that manifest in functional and structural properties of the brain and possibly other clinical and biologic measures. …”
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“…INTRODUCTION: Effective delivery of healthcare in complex systems requires managing interdependencies between professions and organisational units. …”
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“…Methods from the interdisciplinary field of systems science, including models of complex systems, have been increasingly applied to biomedical applications and show promise for generating insight for traumatic brain injury. …”
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“…Innovation platforms are proposed as a novel type of network because of their diverse stakeholder composition and focus on problem solving within complex systems. Thus, they have potential applicability to health systems strengthening initiatives, even though they have been predominantly applied in the international agricultural development sector. …”
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“…This helps explain why, unusually, nearly all feasible systems studied here are locally stable. Large complex systems may thus be even more fragile than May predicted, given the difficulty of assembling a feasible system. …”
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“…Mass spectrometry (MS)-based proteomics now has the potential to document bacterial physiology within these complex systems. Global proteome profiling using MS, known as data dependent acquisition (DDA), is limited by the stochastic nature of ion selection, decreasing the detection of low abundance peptides. …”
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“…We validate the method against high-fidelity model results and illustrate the application of multifidelity analysis in predicting rare event trajectories, performing sensitivity analyses and extrapolating predictions to very low frequencies in complex systems. We believe that our approach will complement ongoing efforts to enable accurate prediction of rare event dynamics in high-fidelity computational models.…”
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“…MOTIVATION: A series of recently introduced algorithms and models advocates for the existence of a hyperbolic geometry underlying the network representation of complex systems. Since the human protein interaction network (hPIN) has a complex architecture, we hypothesized that uncovering its latent geometry could ease challenging problems in systems biology, translating them into measuring distances between proteins. …”
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“…Functional complex networks have meant a pivotal change in the way we understand complex systems, being the most outstanding one the human brain. …”
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“…Continental transform fault systems are fundamental features in plate tectonics. These complex systems often constitute multiple fault strands with variable spatio-temporal histories. …”
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“…Highly connected networks generally improve resilience in complex systems. We present a novel application of this paradigm and investigated the potential for anthropogenic structures in the ocean to enhance connectivity of a protected species threatened by human pressures and climate change. …”
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“…A large portion of the new protein carriers under investigation are recombinant ones, but more complex systems such as Outer Membrane Vesicles and other nanoparticles are being investigated. …”
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“…Interactions and emergent processes are essential for research on complex systems involving many components. Most studies focus solely on pairwise interactions and ignore higher-order interactions among three or more components. …”
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“…Accordingly, with the rise of network science for modeling complex systems, many methods for robustness estimation and network dismantling have been developed and applied to real-world problems. …”
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“…In analysis of multi-component complex systems, such as neural systems, identifying groups of units that share similar functionality will aid understanding of the underlying structures of the system. …”
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“…Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex systems of iron piracy to circumvent nutritional immunity. …”
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