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  1. 2641
    “…Taken together, our results not only demonstrate that ex vivo networks show a sensitivity to NSs and BDZs comparable to that expressed in vivo, but also provide a new global in vitro description that can help in understanding their activity in more complex systems.…”
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    Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array recording study
  2. 2642
    “…CONCLUSIONS: Transmission models have been used to understand complex systems and to predict the impact of control policies. …”
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    Modelling the transmission of healthcare associated infections: a systematic review
  3. 2643
    “…The resulting microRNA and TF co-regulatory networks are publicly available for further exploration to generate or evaluate own hypotheses of the pathogenesis of OS (http://www.complex-systems.uni-muenster.de/co_networks.html).…”
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    How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation
  4. 2644
    “…Our results elucidating the cross-regulations among NF-κB, p53, and microRNAs provide insights into the complex regulatory mechanisms underlying HNSCC, and shows an efficient approach to inferring gene regulatory programs in biological complex systems.…”
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    Unraveling Regulatory Programs for NF-kappaB, p53 and MicroRNAs in Head and Neck Squamous Cell Carcinoma
  5. 2645
    “…The approach is useful for assessing resilience of alternative states across ecological and other complex systems.…”
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    Inferring the Relative Resilience of Alternative States
  6. 2646
    “…Application of the software to stem cell and breast cancer demonstrates that it is an effective tool for understanding regulatory mechanisms in biological complex systems. PTHGRN web server is publically available at web site http://www.byanbioinfo.org/pthgrn.…”
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    PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data
  7. 2647
    “…Similar to other complex systems in nature (e.g., a hunting pack, flocks of birds), sports teams have been modeled as social neurobiological systems in which interpersonal coordination tendencies of agents underpin team swarming behaviors. …”
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    Numerical Relations and Skill Level Constrain Co-Adaptive Behaviors of Agents in Sports Teams
  8. 2648
    “…The physiological processes for maintaining health, however, are complex systems that depend upon interactions between multiple nutrients, environmental factors, and genetic makeup. …”
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    Genetic associations with micronutrient levels identified in immune and gastrointestinal networks
  9. 2649
    “…Cell cycle models able to capture population heterogeneity facilitate in depth understanding of these complex systems and enable systematic formulation of culture strategies to improve growth and productivity. …”
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    Cyclin and DNA Distributed Cell Cycle Model for GS-NS0 Cells
  10. 2650
    “…Stochastic stimulation techniques allow for the careful study of complex systems in biology and medicine and are ideal for the investigation of strategies aimed at CSC eradication. …”
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    Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response
  11. 2651
    “…However, it is also desirable to investigate the effects of complex mixtures on complex systems such as living cells including the natural multitude of signalling pathways. …”
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    Proteomic and Metabolomic Analyses Reveal Contrasting Anti-Inflammatory Effects of an Extract of Mucor Racemosus Secondary Metabolites Compared to Dexamethasone
  12. 2652
    “…The appearance of novel structures and dynamics during this process of development of matter in complex systems has been called emergence. Social neuroscience (SN), an interdisciplinary field that aims to investigate the biological mechanisms that underlie social structures, processes, and behavior and the influences between social and biological levels of organization, has affirmed the necessity for including social context as an essential element to understand the human behavior. …”
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    The social neuroscience and the theory of integrative levels
  13. 2653
    “…SUMMARY: This research proposed a good example for the rapid identification of major constituents in complex systems such as herbs using sensitive, accurate and specific method coupling HPLC with DAD and MS, which facilitate the clarification of phytochemical composition of herbal medicine for better understanding of their nature and biological activities. …”
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    Identification and Quantification of the Major Constituents in Egyptian Carob Extract by Liquid Chromatography–Electrospray Ionization-Tandem Mass Spectrometry
  14. 2654
    por Fürtauer, Lisa, Nägele, Thomas
    Publicado 2016
    “…The interpretation and testable hypothesis generation from experimental data on such complex systems is a challenging step in biological research and biotechnological applications. …”
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    Approximating the stabilization of cellular metabolism by compartmentalization
  15. 2655
    “…The visualizations provide an intuitive representation of the scale and dynamics of these complex systems, are easily accessible for a broad interest group, and are biologically insightful. …”
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    Innovative Visualizations Shed Light on Avian Nocturnal Migration
  16. 2656
    “…This paper suggests the use of techniques from complex systems science in describing and simulating healthy or deviating behavior of the immune system in its biopsychosocial surroundings. …”
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    Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders
  17. 2657
    por Der, Ralf, Martius, Georg
    Publicado 2017
    “…While very successful in many applications, self-organized control schemes seem to be favored in large complex systems with unknown dynamics or which are difficult to model. …”
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    Self-Organized Behavior Generation for Musculoskeletal Robots
  18. 2658
    “…However, poor scaling often renders direct ab initio calculations intractable for large or complex systems. There are two obvious avenues through which to remedy this problem: (i) develop new, less expensive methods to calculate system properties, or (ii) make existing methods faster. …”
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    Discovering charge density functionals and structure-property relationships with PROPhet: A general framework for coupling machine learning and first-principles methods
  19. 2659
    “…Regarding analysis, 3D visualization has proven to be a useful tool for the evaluation of complex systems. However, the large number of neurons in non-trivial circuits, together with their intricate geometry, makes the visualization of a neuronal scenario an extremely challenging computational problem. …”
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    NeuroTessMesh: A Tool for the Generation and Visualization of Neuron Meshes and Adaptive On-the-Fly Refinement
  20. 2660
    “…Coupled mechanical and electrical design approaches enable layout optimization, assembly processes and encapsulation schemes to yield 3D configurations that satisfy requirements in demanding, complex systems, such as wireless, skin-compatible electronic sensors.…”
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    Self-assembled three dimensional network designs for soft electronics
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