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  1. 2681
    “…Background: The topological analysis of networks extracted from different types of “omics” data is a useful strategy for characterizing biologically meaningful properties of the complex systems underlying these networks. In particular, the biological significance of highly connected genes in diverse molecular networks has been previously determined using data from several model organisms and phenotypes. …”
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    Hub genes in a pan-cancer co-expression network show potential for predicting drug responses
  2. 2682
    “…BACKGROUND: Bacterial surfaces are complex systems, constructed from membranes, peptidoglycan and, importantly, proteins. …”
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    Greedy de novo motif discovery to construct motif repositories for bacterial proteomes
  3. 2683
    por Hiscock, Tom W.
    Publicado 2019
    “…Whilst simple in principle, this task is challenging from a computational perspective, since gene circuit models are complex systems with many parameters. In this work, we adapted machine-learning algorithms to significantly accelerate gene circuit discovery. …”
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    Adapting machine-learning algorithms to design gene circuits
  4. 2684
    “…This study applied a water–energy–food (WEF) nexus analytical livelihoods model with complex systems understanding to assess rural livelihoods, health, and well-being in southern Africa, recommending tailor-made adaptation strategies for the region aimed at building resilient rural communities. …”
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    The Water–Energy–Food Nexus as a Tool to Transform Rural Livelihoods and Well-Being in Southern Africa
  5. 2685
    “…Each risk factor impacts multiple systems, making LOAD a complex systems biology challenge. To investigate interactions between LOAD risk factors, we performed multiple scale analyses, including metabolomics, transcriptomics, brain magnetic resonance imaging (MRI), and beta-amyloid assessment, in 16 months old male and female mice with humanized human APOE3 (hAPOE3) or APOE4 (hAPOE4) genes. …”
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    Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice
  6. 2686
    “…In order to develop a high-throughput qPCR approach for the rapid and cost-efficient quantification of microbial species in complex systems such as fermented foods (for instance, cheese), the preliminary setup of qPCR assays working efficiently under identical PCR conditions is required. …”
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    SpeciesPrimer: a bioinformatics pipeline dedicated to the design of qPCR primers for the quantification of bacterial species
  7. 2687
    por Kohler, Katharina, Ercole, Ari
    Publicado 2020
    “…INTRODUCTION: Hospitals are complex systems and optimising their function is critical to the provision of high quality, cost effective healthcare. …”
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    Can network science reveal structure in a complex healthcare system? A network analysis using data from emergency surgical services
  8. 2688
    “…In this research, we focus on nonlinear complex systems, and show their capability in representation and learning of different functions. …”
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    Nonlinear dynamics based machine learning: Utilizing dynamics-based flexibility of nonlinear circuits to implement different functions
  9. 2689
    por Cuevas, Erik
    Publicado 2020
    “…On the other hand, agent-based modeling is a relatively new approach to model complex systems composed of agents whose behavior is described using simple rules. …”
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    An agent-based model to evaluate the COVID-19 transmission risks in facilities
  10. 2690
    “…Nevertheless, very few have examined participant experiences in depth in order to understand which programmatic aspects they regard as most valuable relative to leadership in increasingly complex systems, or whether and how learnings may sustain over time. …”
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    Leadership development in complex health systems: a qualitative study
  11. 2691
    “…BACKGROUND: The study of oral health literacy (OHL) is likely to gain new and interesting insights with the use of network analysis, a powerful analytical tool that allows the investigation of complex systems of relationships. Our aim was to investigate the relationships between oral health literacy and oral health-related factors in a sample of Indigenous Australian adults using a network analysis approach. …”
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    The utility of network analysis in the context of Indigenous Australian oral health literacy
  12. 2692
    “…Thus far only approaches based at the individual panel level have been investigated, while the more complex, systems approach remains unexplored. Here, we perform the first wind tunnel scaled solar farm experiments to investigate the potential for temperature reduction through system-level flow enhancement. …”
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    Utility-scale solar PV performance enhancements through system-level modifications
  13. 2693
    “…Stage 3 will further refine and interrogate the theories testing them against substantive theory on leadership of complex systems and through the experiences and expertise of the stakeholder group. …”
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    Understanding key mechanisms of successfully leading integrated team-based services in health and social care: protocol for a realist synthesis
  14. 2694
    “…In the meantime, we hope our study design serves as a source of inspiration for other public health intervention studies in complex systems.…”
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    A System Dynamics and Participatory Action Research Approach to Promote Healthy Living and a Healthy Weight among 10–14-Year-Old Adolescents in Amsterdam: The LIKE Programme
  15. 2695
    por Williams, Richard A.
    Publicado 2021
    “…The complexity of systems now under consideration (be they biological, physical, chemical, social, etc), together with the technicalities of experimentation in the real-world and the non-linear nature of system dynamics, means that computational modelling is indispensible in the pursuit of furthering our understanding of complex systems. Agent-based modelling and simulation is rapidly increasing in its popularity, in part due to the increased appreciation of the paradigm by the non-computer science community, but also due to the increase in the usability, sophistication and number of modelling frameworks that use the approach. …”
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    User experiences using FLAME: A Case study modelling conflict in large enterprise system implementations
  16. 2696
    “…However, separate pump-probe experiments at different absorption edges still lack a unified timing, when comparing the dynamics in complex systems. Here, we report on an experiment using a dedicated optical element and the two-color emission of the FERMI XUV free-electron laser to follow the charge and spin dynamics in composite materials at two distinct absorption edges, simultaneously. …”
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    Simultaneous two-color snapshot view on ultrafast charge and spin dynamics in a Fe-Cu-Ni tri-layer
  17. 2697
    “…However, the existing methods are based on traditional entropy measures, which only assess a single time scale and often are unable to fully characterize the dynamics generated by highly complex systems, such as the heart during AF. The present work then explores whether a multi-scale entropy (MSE) analysis of the f-waves may provide early prediction of AF recurrence after ECV. …”
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    Multi-scale Entropy Evaluates the Proarrhythmic Condition of Persistent Atrial Fibrillation Patients Predicting Early Failure of Electrical Cardioversion
  18. 2698
    “…Process mapping is a systems thinking approach used to understand, analyse and optimise processes within complex systems. We aim to demonstrate how this methodology can be applied during disease outbreaks to strengthen response and health systems. …”
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    Systems thinking for health emergencies: use of process mapping during outbreak response
  19. 2699
    “…OBJECTIVES: We describe how the failure to consider the complex systems that characterize diverse real-world conditions may doom promising new approaches prematurely. …”
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    Systems Science Approaches for Global Environmental Health Research: Enhancing Intervention Design and Implementation for Household Air Pollution (HAP) and Water, Sanitation, and Hygiene (WASH) Programs
  20. 2700
    “…Understanding the mechanisms around these similarities and differences has the potential to not only improve vascularized composite allotransplantation outcomes but also outcomes for all types of transplants and to contribute to our understanding of how complex systems of immunity and function work together. …”
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    Evolution of the rat hind limb transplant as an experimental model of vascularized composite allotransplantation: Approaches and advantages
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