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  1. 2781
    “…Molecular mechanisms underlying the protective effect of TAX in complex systems such as the brain remain poorly understood. …”
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    A Comparative Analysis of Neuroprotective Properties of Taxifolin and Its Water-Soluble Form in Ischemia of Cerebral Cortical Cells of the Mouse
  2. 2782
    “…As communities are complex systems with dynamic relationships and interactions, a deeper understanding of the community’s structures is crucial for implementation. …”
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    O.5.3-5 Existing structures for physical activity promotion: the role of resources, political support, intersectoral collaboration, and participation in six pilot communities - a comparative case study-
  3. 2783
    “…BACKGROUND: Simulation models support decision-making by helping public health practitioners evaluate the potential effects of interventions in complex systems and their ultimate health impacts. However, many public health professionals remain unfamiliar with constructing simulation models and how best to use their outputs for decision-making due to a lack of training. …”
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    Competency framework on simulation model-based decision-making for Master of Public Health students
  4. 2784
    “…CONCLUSIONS: At the group level, connectiveness between NA items was substantially weaker in depressed patients compared to controls. As in complex systems strong internal connectivity facilitates “critical transitions” to different states, this may reflect (or explain) the persistence of a chronically depressed state. …”
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    Associations in time between salivary cortisol and emotions in depressed patients and controls
  5. 2785
    “…During a detailed characterization, we proved that the Good pH probe is reversible, exhibits no temperature dependence between 15 and 40 °C, has low sensitivity to the ionic strength up to 1100 mM, and is applicable in more complex systems, in which other components significantly superimpose the spectral features of MOPS. …”
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    The Good pH probe: non-invasive pH in-line monitoring using Good buffers and Raman spectroscopy
  6. 2786
    por Wuchty, Stefan, Almaas, Eivind
    Publicado 2005
    “…BACKGROUND: The modeling of complex systems, as disparate as the World Wide Web and the cellular metabolism, as networks has recently uncovered a set of generic organizing principles: Most of these systems are scale-free while at the same time modular, resulting in a hierarchical architecture. …”
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    Evolutionary cores of domain co-occurrence networks
  7. 2787
    por Edgren, Lars
    Publicado 2008
    “…COMPLEX ADAPTIVE SYSTEMS (CASS): The term ‘complex system’ emphasizes that the necessary competence to perform a task is not owned by any one part, but comes as a result of co-operation within the system. …”
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    The meaning of integrated care: a systems approach
  8. 2788
    “…A central theme of systems biology is the use of computational modeling to reconstruct complex systems from a wealth of reductionist, molecular data (e.g., gene/protein expression, signal transduction activity, metabolic activity, etc.). …”
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    Multiway modeling and analysis in stem cell systems biology
  9. 2789
    “…CONCLUSIONS: Genome-wide, large-scale "omics" experimental technologies give different, complementary perspectives on the structure and regulatory properties of complex systems. Even the relatively simple, integrated workflow presented here offers opportunities not only for filtering data noise intrinsic in high throughput data, but also to progressively extract novel information that would have remained hidden otherwise. …”
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    Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes
  10. 2790
    “…This evidences an inflationary mode of evolution where the system diversity; 1) expands continuously alternating vertical and gradual processes of phylogenetic divergence with episodes of modular, saltatory and reticulate evolution; 2) is governed by the intrinsic capability of distinct LTR retroelement host-communities to self-organize their phenotypes according to emergent laws characteristic of complex systems. REVIEWERS: This article was reviewed by Eugene V. …”
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    Network dynamics of eukaryotic LTR retroelements beyond phylogenetic trees
  11. 2791
    “…However, in these complex systems, a potential contribution of endogenous proteins to this function cannot be excluded. …”
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    Functional Reconstitution into Liposomes of Purified Human RhCG Ammonia Channel
  12. 2792
    “…A significant need exists to identify simple but effective implementation strategies to adopt complex practices within complex systems of care. Emerging evidence suggests that facilitation may be an effective integrative implementation strategy for adoption of complex practices. …”
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    Employing external facilitation to implement cognitive behavioral therapy in VA clinics: a pilot study
  13. 2793
    “…An in-depth understanding of complex systems, like the one consisting of HIV, TB and related therapies, is an open great challenge, on the boundaries of bioinformatics, computational and systems biology. …”
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    Formal reasoning on qualitative models of coinfection of HIV and Tuberculosis and HAART therapy
  14. 2794
    “…In this study, we tried to assess respiratory complexity during weaning trials, using different non-linear methods derived from theory of complex systems, in a cohort of surgical critically ill patients. …”
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    Study of multiparameter respiratory pattern complexity in surgical critically ill patients during weaning trials
  15. 2795
    “…The algorithm can be flexibly adjusted to suit the complexity of the dynamic model behaviour, inviting automation in the metamodelling of complex systems.…”
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    Hierarchical Cluster-based Partial Least Squares Regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models
  16. 2796
    por Bardwell, David A., Adjiman, Claire S., Arnautova, Yelena A., Bartashevich, Ekaterina, Boerrigter, Stephan X. M., Braun, Doris E., Cruz-Cabeza, Aurora J., Day, Graeme M., Della Valle, Raffaele G., Desiraju, Gautam R., van Eijck, Bouke P., Facelli, Julio C., Ferraro, Marta B., Grillo, Damian, Habgood, Matthew, Hofmann, Detlef W. M., Hofmann, Fridolin, Jose, K. V. Jovan, Karamertzanis, Panagiotis G., Kazantsev, Andrei V., Kendrick, John, Kuleshova, Liudmila N., Leusen, Frank J. J., Maleev, Andrey V., Misquitta, Alston J., Mohamed, Sharmarke, Needs, Richard J., Neumann, Marcus A., Nikylov, Denis, Orendt, Anita M., Pal, Rumpa, Pantelides, Constantinos C., Pickard, Chris J., Price, Louise S., Price, Sarah L., Scheraga, Harold A., van de Streek, Jacco, Thakur, Tejender S., Tiwari, Siddharth, Venuti, Elisabetta, Zhitkov, Ilia K.
    Publicado 2011
    “…The results also highlight the many challenges posed by more complex systems and show that there are still issues to be overcome.…”
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    Towards crystal structure prediction of complex organic compounds – a report on the fifth blind test
  17. 2797
    “…Stochastic modelling is a useful tool for increasing understanding of the processes underlying complex systems-affecting disorders such as AD, providing a rapid and inexpensive strategy for testing putative new therapies. …”
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    Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach
  18. 2798
    “…Commissioners adopting an incremental approach to service change in defined and manageable areas of work appeared to be more successful in terms of delivering planned changes in service delivery than those attempting to bring about wide-scale change across complex systems. CONCLUSIONS: Commissioning for long-term condition services challenges the conventional distinction between commissioners and providers with a significant amount of work focused on redesigning services in partnership with providers. …”
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    The work of commissioning: a multisite case study of healthcare commissioning in England's NHS
  19. 2799
    “…Early and sustained cardiac ER stress could result in detrimental irreversible consequences in urban children, and while highly complex systems maintain myocardial homeostasis, failure to compensate for chronic myocardial inflammation, oxidative and ER stress, and particles damaging myocardial organelles may prime the development of pathophysiological cardiovascular states in young urbanites. …”
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    Up-Regulation of mRNA Ventricular PRNP Prion Protein Gene Expression in Air Pollution Highly Exposed Young Urbanites: Endoplasmic Reticulum Stress, Glucose Regulated Protein 78, and Nanosized Particles
  20. 2800
    “…Mathematical modelling provides an attractive approach for analysis of complex systems and some models may prove useful in systems pharmacology approaches to drug discovery. …”
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    Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms
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