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  1. 2941
    “…Thus, the understanding gained from such correlations on a prototypical self-assembling motif such as BTA will aid in designing more complex systems with distinct functions.…”
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    Cooperativity Scale: A Structure–Mechanism Correlation in the Self-Assembly of Benzene-1,3,5-tricarboxamides
  2. 2942
    “…Our findings suggest that low income minority populations, such as Hispanic, African American and American Indian in this region continue to have a higher risk for HIV acquisition and highlights the ongoing need to expand research on how these populations perceive their risk for HIV and navigate complex systems, such as health insurance, when seeking clinical services for PreP. …”
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    PrEP Uptake and Emergent HIV infections in Southern Arizona: Is There A Disconnect?
  3. 2943
    “…BACKGROUND: The advances in target control of complex networks not only can offer new insights into the general control dynamics of complex systems, but also be useful for the practical application in systems biology, such as discovering new therapeutic targets for disease intervention. …”
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    A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification
  4. 2944
    “…In addition to improving school-based mental health, these findings will spur future implementation science that considers the relationships across organizations and optimize the capacity of implementation science to guide practice in increasingly complex systems of care.…”
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    The impact of inter-organizational alignment (IOA) on implementation outcomes: evaluating unique and shared organizational influences in education sector mental health
  5. 2945
    “…This paper describes the planned economic evaluation of WHO STOPS and examines the methodological challenges for economic evaluation of a complex systems-based intervention. METHODS AND ANALYSIS: Economic evaluation alongside a stepped-wedge cluster randomised controlled trial in regional and rural communities in Victoria, Australia. …”
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    Protocol for an economic evaluation of WHO STOPS childhood obesity stepped-wedge cluster randomised controlled trial
  6. 2946
    “…Using mixed methods and drawing on complex systems thinking, it will make an important contribution to an expanding literature evaluating interventions not suited to traditional epidemiological research.…”
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    Exploring the impact of public health teams on alcohol premises licensing in England and Scotland (ExILEnS): procotol for a mixed methods natural experiment evaluation
  7. 2947
    “…Purpose: Potentially preventable hospitalizations (PPH) are minimized when adults (usually with multiple morbidities ± frailty) benefit from alternatives to emergency hospital use. A complex systems and anticipatory journey approach to PPH, the Patient Journey Record System (PaJR) is proposed. …”
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    Anticipatory Care in Potentially Preventable Hospitalizations: Making Data Sense of Complex Health Journeys
  8. 2948
    “…Recent efforts within our group have focused on extending the ArM technology to create complex systems for integration into biological cascade reactions and in vivo. …”
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    Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology: Enzymatic Cascades and Directed Evolution
  9. 2949
    por Brandner, Juergen J.
    Publicado 2019
    “…Techniques for correlated measurements may include commonly used techniques like thermocouples or pressure sensors as well as more complex systems like gas chromatography, mass spectrometry, infrared or ultraviolet spectroscopy and many others. …”
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    In-Situ Measurements in Microscale Gas Flows—Conventional Sensors or Something Else?
  10. 2950
    “…Computational models have been used over the years to help understand this problem, as they are capable of representing complex systems such as this. The aim of this work was to use a computational model of cholesterol metabolism to better understand why, in certain studies involving the oldest old (persons ≥ 85 years), high blood cholesterol levels have been associated with a decreased risk of death. …”
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    Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms
  11. 2951
    “…Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs, relative to sphere culture. …”
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    Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions
  12. 2952
    “…The ‘complexity turn’ has drawn attention to the limitations of relying on causal inference from randomised controlled trials alone for understanding whether, and under which conditions, interventions in complex systems improve health services or the public health, and what mechanisms might link interventions and outcomes. …”
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    Case study research for better evaluations of complex interventions: rationale and challenges
  13. 2953
    “…When represented as a network (graph), these data become useful for modeling entities and interactions in biological and similar complex systems. In the field of network biology and network medicine, there is a particular interest in predicting results from drug–drug, drug–disease, and protein–protein interactions to advance the speed of drug discovery. …”
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    Application of network link prediction in drug discovery
  14. 2954
    “…Finally, based on the paradigm of complex systems and systemic modelling, we created the co.LAB generic design framework and specifications to allow its implementation in a collaborative web platform. …”
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    The co.LAB Generic Framework for Collaborative Design of Serious Games: Development Study
  15. 2955
    “…While much valuable health care management research has concentrated on administrative data analysis, this approach often falls short of providing actionable information essential for effective management of specific system implementations and complex systems. This comprehensive performance analysis of a hospital-wide system illustrates application of various analysis approaches to support understanding specific system behaviors and identify leverage points for improvement. …”
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    Characterizing rescue performance in a tertiary care medical center: a systems approach to provide management decision support
  16. 2956
    “…This research agenda proposes new organisational theory perspectives—including considering ships as organisations; types of organisations (highly reliable organisations or self-organised); complex systems and socio-technical systems theories for digitalised ships; the role of power; and developing dynamic safety capabilities for learning ships. …”
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    Reducing maritime accidents in ships by tackling human error: a bibliometric review and research agenda
  17. 2957
    “…BACKGROUND: Health systems are complex systems involving a vast range of actors. In West Africa, they are often not accessible or responsive. …”
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    Using Information and Communication Technologies to Engage Citizens in Health System Governance in Burkina Faso: Protocol for Action Research
  18. 2958
    “…Five such configurations were identified: (1) prioritisation; (2) emotional labour; (3) complicated/complex systems; (4a) system inadequacies and (4b) differential attention and weighing of risks by organisations; (5) learning. …”
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    Which human factors design issues are influencing system performance in out-of-hours community palliative care? Integration of realist approaches with an established systems analysis framework to develop mid-range programme theory
  19. 2959
    “…CONCLUSIONS: This review emphasized the importance of data generators’ viewpoints and the complex systems of factors that shape their decision to share health information. …”
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    Factors Associated With Willingness to Share Health Information: Rapid Review
  20. 2960
    por Lin, Weifeng, Klein, Jacob
    Publicado 2022
    “…In this Account, we begin by introducing the concept and origin of hydration lubrication, extending from the seminal study of lubrication by hydrated simple ions to more complex systems. We then briefly review different modes of lubrication in synovial joints, focusing primarily on boundary lubrication. …”
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    Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels
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