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  1. 3681
    “…As an important link in the complex system engineering project of open pit mining, the quality of the boundary determines the performance of the project to a large extent. …”
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    Boundary optimization of inclined coal seam open-pit mine based on the ISSA–LSSVR coal price prediction method
  2. 3682
    “…We demonstrate the advantages of the Cockpit platform using several bespoke microscopes, including a simple widefield system and a complex system with adaptive optics and structured illumination. …”
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    Microscope-Cockpit: Python-based bespoke microscopy for bio-medical science
  3. 3683
    “…Wound healing is a complex system including such key players as host, microbe, and treatments. …”
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    Host CD3(+) T-cells can significantly modulate phage treatment effects on bacterial bioburden in mouse models
  4. 3684
    “…Instead, we see a complex system of parallel worlds with local HFGs continuing forager lifeways, and incoming farmers practising mixed economies, with the continuation of these subsistence strategies for at least a millennium after the first encounter with domesticated animals.…”
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    Parallel worlds and mixed economies: multi-proxy analysis reveals complex subsistence systems at the dawn of early farming in the northeast Baltic
  5. 3685
    “…We took advantage of the complex system of worker-to-soldier differentiation in the termitid Procornitermes araujoi, to investigate how a profound modification of body morphology followed by an irreversible shift in task performance are translated in terms of brain structure and size. …”
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    Differentiation of workers into soldiers is associated with a size reduction of higher-order brain centers in the neotropical termite Procornitermes araujoi
  6. 3686
    “…CONCLUSIONS: Our recommendation is that physicians should be able to recognize cheilitis granulomatosa as a possible marker of a more complex systemic disease and proceed first with an accurate physical examination, and further suggest investigations of the bowel. …”
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    Buccal localization of Crohn’s disease with long-term infliximab therapy: a case report
  7. 3687
    “…Mononuclear phagocytes are organized in a complex system of ontogenetically and functionally distinct subsets, that has been best described in mouse and to some extent in human. …”
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    Defining Mononuclear Phagocyte Subset Homology Across Several Distant Warm-Blooded Vertebrates Through Comparative Transcriptomics
  8. 3688
    “…Smaducin-6 interacted with Pellino-1, located in the inner membrane, thereby disrupting the formation of IRAK1-, RIP1-, IKKε-mediated TLR4 signaling complexes. Systemic administration of Smaducin-6 showed a significant therapeutic effect on mouse TLR4-mediated inflammatory disease models, cecal-ligation–puncture (CLP)-induced sepsis, and lipopolysaccharide-induced endotoxemia, by inhibiting pro-inflammatory cytokine production and apoptosis while enhancing neutrophil migration and bacterial clearance. …”
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    Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide
  9. 3689
    “…Especially, the network hub has been considered one of the most important topological properties to interpret a network as a complex system. However, previous structural brain connectome studies have reported network hub regions based on various nodal resolutions. …”
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    Scale-integrated Network Hubs of the White Matter Structural Network
  10. 3690
    por Wang, Meng, Tai, Cheng, E, Weinan, Wei, Liping
    Publicado 2018
    “…The complex system of gene expression is regulated by the cell type-specific binding of transcription factors (TFs) to regulatory elements. …”
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    DeFine: deep convolutional neural networks accurately quantify intensities of transcription factor-DNA binding and facilitate evaluation of functional non-coding variants
  11. 3691
    “…Exploration of AF using information theoretic-based approaches may have the potential to provide new insights into the complex system dynamics of AF, whilst also providing the benefit of being less reliant on empirically derived definitions in comparison to alternate mapping approaches. …”
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    Information Theory and Atrial Fibrillation (AF): A Review
  12. 3692
    “…When single CHMs are combined into CHF, the result is different from the original effect of a single drug and can be better adapted to more diseases with complex symptoms. CHF represent a complex system with multiple components, targets and effects. …”
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    Systems biology approaches in the study of Chinese herbal formulae
  13. 3693
    “…The Fukushima Daiichi nuclear power plant accident caused serious radiocesium ((137)Cs) contamination of the soil in multiple terrestrial ecosystems. Soil is a complex system where minerals, organic matter, and microorganisms interact with each other; therefore, an improved understanding of the interactions of (137)Cs with these soil constituents is key to accurately assessing the environmental consequences of the accident. …”
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    A new perspective on the (137)Cs retention mechanism in surface soils during the early stage after the Fukushima nuclear accident
  14. 3694
    “…Each MDC pathosystems displayed a specific taxonomic diversity and relative abundances constituting a very complex system. The main bacterial drivers of the MDC infection process were identified for both crops at order level. …”
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    The Bacterial Microbiome of Meloidogyne-Based Disease Complex in Coffee and Tomato
  15. 3695
    “…The mammalian immune system protects individuals from infection and disease. It is a complex system of interacting cells and molecules, which has been studied extensively to investigate its detailed function, principally using laboratory mice. …”
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    Network analysis of the immune state of mice
  16. 3696
    “…Canonically, they are involved in the complex system of ribosome biogenesis pivotal to the catalysis of protein translation. …”
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    The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both
  17. 3697
    “…Efforts to tackle one issue can support or hinder progress towards others, often with complex systemic interactions. Thus, each of the SDGs and their corresponding targets may contribute as levers or hurdles towards achieving other SDGs and targets. …”
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    A systems model of SDG target influence on the 2030 Agenda for Sustainable Development
  18. 3698
    “…Previous studies have demonstrated that enterprise food fraud is subject to joint influences of factor at various hierarchical levels within a complex system of stakeholders. To address enterprise food fraud, it is necessary to identify the key such factors and elucidate the functional mechanisms, as well as systematic analysis of the interrelationships among clusters and factors. …”
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    Enterprise Food Fraud in China: Key Factors Identification From Social Co-governance Perspective
  19. 3699
    “…The platform was then evaluated against a set of fifteen needs related to complex system transformation. While the results highlighted concerns about the platform’s usability, feedback was generally positive regarding its effectiveness and potential value in supporting HCAI risk management. …”
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    Evaluation of an Access-Risk-Knowledge (ARK) Platform for Governance of Risk and Change in Complex Socio-Technical Systems
  20. 3700
    “…The constituent elements of such systems are often scattered across multiple firms and across the globe and constitute a complex system consisting of many interacting parts. In the spirit of the "butterfly effect", metaphorically describing the sensitivity to initials conditions of chaotic systems, this book builds an argument that "innovation butterflies" can, in the short term, take up significant amounts of effort and sap efficiencies within individual innovation projects. …”
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    The Innovation Butterfly: Managing Emergent Opportunities and Risks During Distributed Innovation
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