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  1. 3761
    “…Indeed, because the biological environment is a complex system, the traditional approach—based on knowledge about the chemical structures—can not fully explain the nature of interactions between drugs and biological targets. …”
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    Uncovering New Drug Properties in Target-Based Drug–Drug Similarity Networks
  2. 3762
    “…By formally disentangling state and observation processes based on simple yet powerful mathematical properties that can be used to describe many ecological phenomena, hidden Markov models (HMMs) can facilitate inferences about complex system state dynamics that might otherwise be intractable. …”
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    Uncovering ecological state dynamics with hidden Markov models
  3. 3763
    “…The nature of YF transmission dynamics is multifactorial and encompasses a complex system of biotic, abiotic, and anthropogenic factors rendering predictions of emergence highly speculative. …”
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    Re-emergence of yellow fever in the neotropics — quo vadis?
  4. 3764
    “…Currently, the modelling of a complex system such as the spread of COVID-19 infection is among the topical issues. …”
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    Graph modelling for tracking the COVID-19 pandemic spread
  5. 3765
    “…Identifying the input-output response properties of this complex system is necessary to design surface deformations accurately and precisely. …”
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    Identification and Evaluation of the Face System of a Child Android Robot Affetto for Surface Motion Design
  6. 3766
    “…SIMPLE SUMMARY: The tumor is a complex system that is composed of tumor cells, themselves surrounded by many other different cell types. …”
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    Cancer Cells Resistance Shaping by Tumor Infiltrating Myeloid Cells
  7. 3767
    “…The triacetin assisted the interactions between biopolymer chains in this polyelectrolyte complexed system. In contrast, the chitosan/alginate material plasticized by [C(2) mim][OAc] displayed the most apparent phase separation, poorest mechanical properties, and highest surface hydrophilicity, behavior associated with the disruption of polyelectrolyte complexation and hydrogen bonding between biopolymer chains. …”
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    Unexpected Plasticization Effects on the Structure and Properties of Polyelectrolyte Complexed Chitosan/Alginate Materials
  8. 3768
    por Mistriotis, Antonis
    Publicado 2021
    “…As shown by several authors, all living systems can be classified in a multi-level hierarchy of increasing complexity. Systems in all hierarchical levels are characterized by a small set of the same attributes defining Life. …”
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    A universal model describing the structure and functions of living systems
  9. 3769
    “…Polymer‐protein complexing systems have been extensively studied because of their wide application in biomedicine and industry. …”
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    Aggregation Behavior of Poly(Acrylic acid‐co‐Octadecyl Methacrylate) and Bovine Serum Albumin in Aqueous Solutions
  10. 3770
    “…These interactions constitute a very complex system of highly regulated pathways known as the innate immune system of the mosquito, which produces antimicrobial peptides that act as effector molecules against bacterial and fungal infections. …”
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    Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti
  11. 3771
    “…The mechanisms of endocrine disruption involve a complex system of pathways that communicate across the body to stimulate specific receptors that bind DNA and regulate the expression of a suite of genes. …”
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    Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions
  12. 3772
    “…Glomerular kidney disease causing nephrotic syndrome is a complex systemic disorder and is associated with significant morbidity in affected patient populations. …”
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    A Novel Model for Nephrotic Syndrome Reveals Associated Dysbiosis of the Gut Microbiome and Extramedullary Hematopoiesis
  13. 3773
    “…Here, taking as paradigm protein structural and interaction networks, we review some of the most relevant results dealing with between networks communication shedding light on the basic principles of complex system control and dynamics and offering a more realistic frame of causation in biology.…”
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    Networks of Networks: An Essay on Multi-Level Biological Organization
  14. 3774
    “…To this end, game theory provides a bottom-up modeling paradigm to capture the strategic interactions among multiple components of the complex system and enables a holistic view to understand and design cyber-physical-human control systems. …”
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    Dynamic games for secure and resilient control system design
  15. 3775
    por Schneider, Tamar
    Publicado 2021
    “…Thus, the holobiont’s boundaries and immunity are defined by the persistence of its complex system of interactions integrating existing and new interactions. …”
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    The holobiont self: understanding immunity in context
  16. 3776
    “…Proper breakdown, absorption, and elimination of these trace metals is a tightly regulated process that requires crosstalk between the host and these micronutrients. The gut is a complex system that serves as the interface between these components, but other factors that contribute to this delicate interaction are not well understood. …”
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    Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper
  17. 3777
    “…These axioms refer to society as a complex system, not to particular interactions. GMt axioms are not a model of social games, but rather an axiomatic description of social life as a game, revealing its systematic character, complexity, and possible deterioration.…”
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    Gift Game Metatheory: Social Interaction and Interpersonal Growth
  18. 3778
    “…Consistent with avid engagement by C1q and its complex system of regulatory factors, these results suggest that complement-mediated antibody activities demonstrate a high degree of context dependence and motivate revisiting the role of complement in antibody-mediated prevention of HIV-1 infection by next-generation bnAbs in new translational studies in animal models.…”
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    Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity
  19. 3779
    “…This question is challenging to study, and previous research has reached mixed conclusions, because collective decision outcomes depend on the insufficiently understood complex system of cognitive strategies, task properties, and social influence processes. …”
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    Dynamical system model predicts when social learners impair collective performance
  20. 3780
    “…Implementation has involved coordination of multiple policies and interventions for different life stages, care groups, care settings and local context within a dynamic and complex system. DISCUSSION: Relational and citizen led approaches are critical for success, but it takes time to build trusting relationships, influence organisational and professional cultures and cede power. …”
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    Health and Social Care Reform in Scotland – What Next?
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