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  1. 3941
    por Scott, Richard E, Mars, Maurice
    Publicado 2013
    “…To address this gap, this paper further develops an eHealth Strategy Development Framework, basing it upon a conceptual framework and relevant theories of strategy and complex system analysis available from the literature. …”
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    Principles and Framework for eHealth Strategy Development
  2. 3942
    “…The almost of studies for network identification focused on the improvement of computational efficiency in large-scale network inference of complex system with cyclic relations and few attempted have been done for answering practical problem occurred in real biological systems. …”
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    An approach for dynamical network reconstruction of simple network motifs
  3. 3943
    “…The results indicated MIPs with the characteristics of specific adsorption ability and large scale preparation can be an effective approach to study the interaction mechanism among active ingredients of complex system such as TCM at system-level. And this work would provide a new idea to study the interactions among active ingredients of TCM.…”
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    System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology
  4. 3944
    “…Aneurysmal subarachnoid haemorrhage is a neurological syndrome with complex systemic complications. The rupture of an intracranial aneurysm leads to the acute extravasation of arterial blood under high pressure into the subarachnoid space and often into the brain parenchyma and ventricles. …”
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    The critical care management of poor-grade subarachnoid haemorrhage
  5. 3945
    “…Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. …”
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    Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity
  6. 3946
    “…The microbiota can modulate changes in gut barrier as well as metabolic and inflammatory responses. This highly complex system involves numerous microbiota-derived factors. …”
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    Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function
  7. 3947
    “…CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex system can recognize and cut non-self DNA in order to provide the prokaryotic organisms a strong defense against foreign viral or plasmid attacks and make the cell immune from further assaults. …”
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    Type II CRISPR/Cas9 approach in the oncological therapy
  8. 3948
    “…Mitochondrial dynamics are regulated by a complex system of proteins representing the mitochondrial quality control (MQC). …”
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    Fusion or Fission: The Destiny of Mitochondria In Traumatic Brain Injury of Different Severities
  9. 3949
    por Borchert, Andrew J., Downs, Diana M.
    Publicado 2017
    “…Further, the data emphasized the value of integrating global approaches with biochemical genetic approaches to understand the complex system of microbial metabolism.…”
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    Endogenously generated 2-aminoacrylate inhibits motility in Salmonella enterica
  10. 3950
    “…Our brain is a complex system of interconnected regions spontaneously organized into distinct networks. …”
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    An Evolutionary Game Theory Model of Spontaneous Brain Functioning
  11. 3951
    “…OBJECTIVES: Alcohol misuse is a complex systemic problem. The aim of this study was to explore the feasibility of using a transparent and participatory agent-based modelling approach to develop a robust decision support tool to test alcohol policy scenarios before they are implemented in the real world. …”
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    Harnessing advances in computer simulation to inform policy and planning to reduce alcohol-related harms
  12. 3952
    “…Haemostasis is governed by a highly complex system of interacting proteins. Due to the central role of thrombin, thrombin generation and specifically the thrombin generation curve (TGC) is commonly used as an indicator of haemostatic activity. …”
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    Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration
  13. 3953
    “…This can be of major value in structural studies where specific regions of a complex system can be highlighted, and others rendered invisible. …”
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    The Production of Matchout-Deuterated Cholesterol and the Study of Bilayer-Cholesterol Interactions
  14. 3954
    “…With the development of “omic”-technologies and computational analysis methods, attempts to analyze and understand complex system dynamics are now feasible. However, the decomposition of transcriptomic data sets generated from complete organs remains a major challenge. …”
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    Linking Cell Dynamics With Gene Coexpression Networks to Characterize Key Events in Chronic Virus Infections
  15. 3955
    “…Within this model, we explicitly recognise the role of data and evidence to act as glue holding together this complex system and allowing incremental progress in equitable improvement in the health of urban populations.…”
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    Rethinking health systems in the context of urbanisation: challenges from four rapidly urbanising low-income and middle-income countries
  16. 3956
    “…Since glutathione is a central component of a complex system involved in preserving cellular redox status, we aimed to study whether the expression of the glutathione reductase (Gsr) gene, which encodes an essential enzyme for cellular redox homeostasis, is modulated by the transcription factors critical for self-renewal and pluripotency of ESCs. …”
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    The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells
  17. 3957
    por Müller, Katharina, Foerstendorf, Harald, Steudtner, Robin, Tsushima, Satoru, Kumke, Michael U., Lefèvre, Grégory, Rothe, Jörg, Mason, Harris, Szabó, Zoltán, Yang, Ping, Adam, Christian K. R., André, Rémi, Brennenstuhl, Katlen, Chiorescu, Ion, Cho, Herman M., Creff, Gaëlle, Coppin, Frédéric, Dardenne, Kathy, Den Auwer, Christophe, Drobot, Björn, Eidner, Sascha, Hess, Nancy J., Kaden, Peter, Kremleva, Alena, Kretzschmar, Jerome, Krüger, Sven, Platts, James A., Panak, Petra J., Polly, Robert, Powell, Brian A., Rabung, Thomas, Redon, Roland, Reiller, Pascal E., Rösch, Notker, Rossberg, André, Scheinost, Andreas C., Schimmelpfennig, Bernd, Schreckenbach, Georg, Skerencak-Frech, Andrej, Sladkov, Vladimir, Solari, Pier Lorenzo, Wang, Zheming, Washton, Nancy M., Zhang, Xiaobin
    Publicado 2019
    “…[Image: see text] A comprehensive molecular analysis of a simple aqueous complexing system—U(VI) acetate—selected to be independently investigated by various spectroscopic (vibrational, luminescence, X-ray absorption, and nuclear magnetic resonance spectroscopy) and quantum chemical methods was achieved by an international round-robin test (RRT). …”
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    Interdisciplinary Round-Robin Test on Molecular Spectroscopy of the U(VI) Acetate System
  18. 3958
    “…They help establish Ectocarpus as a model for brown algal holobionts and will enable the research community to produce testable hypotheses about the molecular interactions within this complex system.…”
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    Genome Sequences of 72 Bacterial Strains Isolated from Ectocarpus subulatus: A Resource for Algal Microbiology
  19. 3959
    “…A complex system regulating HLA-C expression in NK cells, driven by an NK-specific promoter that produces alternatively spliced variants of the 5′-UTR has been recently identified. …”
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    Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing
  20. 3960
    “…Furthermore, no potential side effects of Gd–lip were found using a complex system including general biomarkers of toxicity, such as induction of early response genes, oxidative, heat shock and endoplasmic reticulum stress, DNA damage responses, induction of xenobiotic metabolizing enzymes, and changes in sphingolipid metabolism in differentiated HepaRG. …”
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    Gadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages
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