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4001por Rubio-Aliaga, Isabel, Przemeck, Gerhard K. H., Fuchs, Helmut, Gailus-Durner, Valérie, Adler, Thure, Hans, Wolfgang, Horsch, Marion, Rathkolb, Birgit, Rozman, Jan, Schrewe, Anja, Wagner, Sibylle, Hoelter, Sabine M., Becker, Lore, Klopstock, Thomas, Wurst, Wolfgang, Wolf, Eckhard, Klingenspor, Martin, Ivandic, Boris T., Busch, Dirk H., Beckers, Johannes, Hrabé de Angelis, Martin“…Recent studies have demonstrated that this pathway is integral to a complex system of interactions, involving as well other signal transduction pathways, and implicated in distinct human diseases. …”
Publicado 2009
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4002por Leaver, Chad Andrew, Guttmann, Astrid, Zwarenstein, Merrick, Rowe, Brian H, Anderson, Geoff, Stukel, Therese, Golden, Brian, Bell, Robert, Morra, Dante, Abrams, Howard, Schull, Michael J“…BACKGROUND: Rigorous evaluation of an intervention requires that its allocation be unbiased with respect to confounders; this is especially difficult in complex, system-wide healthcare interventions. We developed a short survey instrument to identify factors for a minimization algorithm for the allocation of a hospital-level intervention to reduce emergency department (ED) waiting times in Ontario, Canada. …”
Publicado 2009
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4003por García, Miguel, Pujol, Anna, Ruzo, Albert, Riu, Efrén, Ruberte, Jesús, Arbós, Anna, Serafín, Anna, Albella, Beatriz, Felíu, Juan Emilio, Bosch, Fátima“…These results indicate that, in GSDVII, marked alterations in muscle bioenergetics and erythrocyte metabolism interact to produce a complex systemic disorder. Therefore, GSDVII is not simply a muscle glycogenosis, and Pfkm(−/−) mice constitute a unique model of GSDVII which may be useful for the design and assessment of new therapies.…”
Publicado 2009
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4004por Gao, Jun, Wang, Wen-Yuan, Mao, Ying-Wei, Gräff, Johannes, Guan, Ji-Song, Pan, Ling, Mak, Gloria, Kim, Dohoon, Su, Susan C., Tsai, Li-Huei“…Its mammalian homologue, SIRT1, appears to have evolved complex systemic roles in cardiac function, DNA repair, and genomic stability. …”
Publicado 2010
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4005por Tschinkel, Walter R.“…The tunnels form a complex system that radiates at least 10 to 15 m from the nest with crossconnections between major tunnels. …”
Publicado 2010
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4006por Al Nadaf, Shafagh, Waters, Paul D, Koina, Edda, Deakin, Janine E, Jordan, Kristen S, Graves, Jennifer AM“…In order to deduce how this complex system evolved, we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii). …”
Publicado 2010
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4007por Sturm, Robert“…The ductus receptaculi is a long (up to 25 mm) homogeneous tube, and the accessory glands (total length: 4 to 12 mm) are a complex system of tubes and end lobes with various numbers of ramifications. …”
Publicado 2008
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4008“…Menstruation, delivery and postpartum recovery take place in separate, purpose-built, huts and a complex system of spatial restrictions is observed. CONCLUSIONS: Traditions surrounding childbirth are diverse and have been strictly observed, but are undergoing a shift towards those from neighboring ethnic groups, the Brou and Saek. …”
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4009“…The examples presented here demonstrate that the intrinsic nature of a complex system, which in particular includes a precise relationship between structure and function at different hierarchical levels, can be effectively represented by an olog. …”
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4010por Andersen, Jørgen Vitting, Nowak, Andrzej, Rotundo, Giulia, Parrott, Lael, Martinez, Sebastian“…The nonlinear response allows us to classify price movements of a given stock index as either being generated internally, due to specific economic news for the country in question, or externally, by the ensemble of the world's stock exchanges reacting together like a complex system. The model may provide new insight into the origins and thereby also prevent systemic risks in the global financial network.…”
Publicado 2011
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4011“…The mechanism of operation of this complex system is under constant debate. Here, we report on isolation and enzymatic examination of cytochrome bc(1)-like complexes containing fused cytochrome b subunits in which asymmetrically introduced mutations inactivated individual branches in various combinations. …”
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4012por Price, David J., Clegg, James, Duocastella, Xavier Oliver, Willshaw, David, Pratt, Thomas“…We stress the importance of the combinatorial actions of multiple genes for the development of the numerous specific identities and functions of cells in this exquisitely complex system and their orderly innervation of the cortex.…”
Publicado 2012
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4013“…BACKGROUND: The human brain is a highly complex system that can be represented as a structurally interconnected and functionally synchronized network, which assures both the segregation and integration of information processing. …”
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4014por Huffman, Kelly“…In humans, this regionalization creates a complex system that regulates behavior, cognition, memory, and emotion. …”
Publicado 2012
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4015“…Data assimilation is a valuable tool in the study of any complex system, where measurements are incomplete, uncertain, or both. …”
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4016por Jones, Susan S.“…The evidence is most consistent with a view of early imitation as the product of a complex system of language, cognitive, social, and motor competencies that develop in infancy. …”
Publicado 2012
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4017“…To conclude, this model serves as a powerful tool for both understanding the complex system-level properties of the highly coordinated adaptation process and generating further hypotheses for experimental investigation.…”
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4018por Scheler, Gabriele“…In particular we can deconstruct the complex system into local transfer functions between individual species. …”
Publicado 2013
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4019por Anastasio, Thomas J.“…This regulation involves a highly complex system of intertwined normative and pathological processes, and the sex hormone estrogen contributes to it by influencing the Aβ-regulation system at many different points. …”
Publicado 2013
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4020“…This permits to construct a model for the migration of Sn from the transparent conductive oxide into the TiO(2) scaffold, resulting in alterations in the composition of the complex system which has a direct effect on the DSC performance. …”
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