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  1. 4161
    “…The discovery of microRNAs (miRNAs) added an extra level of intricacy to the already complex system regulating gene expression. These single-stranded RNA molecules, 18–25 nucleotides in length, negatively regulate gene expression through translational inhibition or mRNA cleavage. …”
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    Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancer
  2. 4162
    “…Cellular in silico models are considered a promising and inevitable tool for the understanding of this complex system. Hence, we need to incorporate the information of the differentiation dependent protein expression in cell based systems biological models of tissue homeostasis. …”
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    Nuclear staining and relative distance for quantifying epidermal differentiation in biomarker expression profiling
  3. 4163
    “…CONCLUSIONS: The large number of diverse transporters and genes involved in chemotaxis, motility and quorum sensing suggested that the bacterium may utilize a complex system to adapt to different environments. Structural modeling will provide useful insights on the transporters in L. hongkongensis.…”
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    Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis
  4. 4164
    por Ginghina, C., Bejan, I., Ceck, C.D.
    Publicado 2011
    “…All known information and techniques can be integrated in a complex system of risk assessment. The current trend in risk assessment is to identify coronary artery disease in early forms, before clinical manifestation, and to guide therapy, particularly in patients with intermediate risk, which can be classified in another class of risk based on new obtained information. …”
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    Modern risk stratification in coronary heart disease
  5. 4165
    “…Viruses have evolved elaborate mechanisms to evade or inactivate the complex system of sensors and signaling molecules that make up the host innate immune response. …”
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    Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling
  6. 4166
    “…They deliver essential nutrients, eject waste products, and assist the cell in sensing environmental conditions by forming a complex system of pumps and channels. Although studies have effectively characterized individual M. truncatula transporters in several databases, until now there has been no available systematic database that includes all transporters in M. truncatula. …”
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    Medicago truncatula transporter database: a comprehensive database resource for M. truncatula transporters
  7. 4167
    “…Here we use a naturally complex system in sexual selection studies, the swordtail, to explore how genes associated with mate preference, receptivity, and social affiliation interact in the female brain under specific social conditions. …”
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    Identifying Context-Specific Gene Profiles of Social, Reproductive, and Mate Preference Behavior in a Fish Species with Female Mate Choice
  8. 4168
    “…Oxygen and pH are coupled in the brain through a complex system of blood flow and metabolism as a result of transient neural activity. …”
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    Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates
  9. 4169
    “…The Altar Machine was dated back to the second half of the 18(th) century; it is constituted by carved and painted wood, a complex system of winch and pulleys allows move various statues and parts of the Machine in accordance with the baroque scenography machineries. …”
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    The Altar Machine in the Church Mother of Gangi (Palermo, Italy). Interpretation of the past uses, scientific investigation and preservation challenge
  10. 4170
    por Li, Haiying, Reeves, R. Keith
    Publicado 2013
    “…Furthermore, because the normal flora of the oral cavity is vast and significantly diverse, host immunity must balance a complex system of tolerance and pathogen recognition. …”
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    Functional perturbation of classical natural killer and innate lymphoid cells in the oral mucosa during SIV infection
  11. 4171
    “…Woody plants present a highly complex system of vascular development in which isolated bundles of xylem and phloem gradually unite to form concentric rings of conductive tissue. …”
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    Auxin-Responsive DR5 Promoter Coupled with Transport Assays Suggest Separate but Linked Routes of Auxin Transport during Woody Stem Development in Populus
  12. 4172
    “…By recognising generalist practice as a ‘complex intervention’ (intervening in a complex system), we outline an approach to evaluate impact using action-research principles. …”
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    Generalist solutions to complex problems: generating practice-based evidence - the example of managing multi-morbidity
  13. 4173
    “…CONCLUSION: We suggest that PRES may occur in patients with complex systemic conditions. The prognosis of PRES is usually benign. …”
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    Clinical and Radiological Spectrum of Posterior Reversible Encephalopathy Syndrome
  14. 4174
    “…Using a conditional mapping approach, we identified eQTL dependent on interactions between loci, revealing a complex system of epistasis. Our results illuminate established patterns, including the role of the X chromosome in hybrid sterility. …”
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    Genomic Networks of Hybrid Sterility
  15. 4175
    “…Chinese medicine is a complex system guided by traditional Chinese medicine (TCM) theories, which has proven to be especially effective in treating chronic and complex diseases. …”
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    A Network Pharmacology Study of Chinese Medicine QiShenYiQi to Reveal Its Underlying Multi-Compound, Multi-Target, Multi-Pathway Mode of Action
  16. 4176
    “…Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase, plays complex systemic roles in a variety of processes through deacetylating acetylated histone and other specific substrates. …”
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    Spinal SIRT1 Activation Attenuates Neuropathic Pain in Mice
  17. 4177
    “…The identification of the intentionality of movement is a critical aspect to optimize this complex system. We propose a multimodal detection of the intentionality of movement by fusing signals from EEG, EMG and kinematic sensors (gyroscopes and accelerometry). …”
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    Quality parameters for a multimodal EEG/EMG/kinematic brain-computer interface (BCI) aiming to suppress neurological tremor in upper limbs
  18. 4178
    por Daire, Judith, Gilson, Lucy
    Publicado 2014
    “…Managing with and through others, and in a complex system, requiring self-management, are critical aspects of the job. …”
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    Does identity shape leadership and management practice? Experiences of PHC facility managers in Cape Town, South Africa
  19. 4179
    “…We find that the researcher, and the researcher’s function of generating evidence, is nested within a broader complex system that influences the researcher’s interaction with policymaking. …”
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    Exploring health researchers’ perceptions of policymaking in Argentina: a qualitative study
  20. 4180
    “…The principle is based upon the conformation of the sandwich complex composed of bacterial cells, MMSs, and QDs. The complex system is tagged with QDs for providing the fluorescent signal as part of the detection while magnetic separation is achieved by MMSs. …”
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    Detection of Mycobacterium tuberculosis based on H(37)R(v) binding peptides using surface functionalized magnetic microspheres coupled with quantum dots – a nano detection method for Mycobacterium tuberculosis
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