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761“…The on-going whole genome sequencing and whole cell assays of metabolites and proteins imply that complex systems could ultimately be mastered by perfecting knowledge into great detail. …”
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762por Porcar, Manuel“…I argue here that living organisms, particularly bacterial cells, are not machine-like, engineerable entities, but, instead, factory-like complex systems shaped by evolution. A change of the comparative paradigm in synthetic biology from machines to factories, from hardware to software, and from informatics to economy is discussed.…”
Publicado 2019
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763por Schulman, L. S.“…Examples are given in several areas: the definition of a phase transition (including metastable phases), random walks in which the OR recovers the original space, complex systems, systems in which the number of extrema exceed convenient viewing capacity, and systems in which successful features are displayed, but without the support of known theorems.…”
Publicado 2019
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764por Sundstrom, Shana M., Angeler, David G., Bell, Jesse, Hayes, Michael, Hodbod, Jennifer, Jalalzadeh-Fard, Babak, Mahmood, Rezaul, VanWormer, Elizabeth, Allen, Craig R.“…It accounts for the fundamental tenets of complex systems and explicitly grapples with emergence, including the emergence of novelty, and the emergent property of social-ecological resilience. …”
Publicado 2023
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765“…Networks are essential for analyzing complex systems. However, their growing size necessitates backbone extraction techniques aimed at reducing their size while retaining critical features. …”
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766“…METHODOLOGY/PRINCIPAL FINDINGS: Here, we present an essay-like study in which we propose to use visualized concepts stemming from the theory on dynamical complex systems as a ‘visual metaphor’ to bridge the mental- and molecular-biological domains in schizophrenia. …”
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767“…This approach is well-suited to dealing with complex systems, in particular where data are scarce.…”
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768“…Many complex systems have been found to exhibit critical transitions, or so-called tipping points, which are sudden changes to a qualitatively different system state. …”
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769por Gu, Jiangyong, Zhang, Xinzhuang, Ma, Yimin, Li, Na, Luo, Fang, Cao, Liang, Wang, Zhenzhong, Yuan, Gu, Chen, Lirong, Xiao, Wei, Xu, Xiaojie“…BACKGROUND: Quantitative description of dose–response of a drug for complex systems is essential for treatment of diseases and drug discovery. …”
Publicado 2015
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770por Petticrew, Mark, Knai, Cécile, Thomas, James, Rehfuess, Eva Annette, Noyes, Jane, Gerhardus, Ansgar, Grimshaw, Jeremy M, Rutter, Harry, McGill, Elizabeth“…There is growing interest in the potential for complex systems perspectives in evaluation. This reflects a move away from interest in linear chains of cause-and-effect, towards considering health as an outcome of interlinked elements within a connected whole. …”
Publicado 2019
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771por Bizzarri, Mariano, Giuliani, Alessandro, Pensotti, Andrea, Ratti, Emanuele, Bertolaso, Marta“…The fall of reductionist approaches to explanation leaves biology with an unescapable challenge: how to decipher complex systems. This entails a number of very critical questions, the most basic ones being: “What do we mean by ‘complex’?” …”
Publicado 2019
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772“…Most of China’s technological innovation and regional economic complex systems were in a state of interactive development from 2007 to 2016, except in the three northeastern provinces of Zhejiang, Shanghai, and the western part of the country. …”
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773por Graafland, Catharina E., Gutiérrez, José M., López, Juan M., Pazó, Diego, Rodríguez, Miguel A.“…Complex systems often exhibit long-range correlations so that typical observables show statistical dependence across long distances. …”
Publicado 2020
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774por Luchnikov, Ilia A., Ryzhov, Alexander, Stas, Pieter-Jan, Filippov, Sergey N., Ouerdane, Henni“…Thermodynamics is a theory of principles that permits a basic description of the macroscopic properties of a rich variety of complex systems from traditional ones, such as crystalline solids, gases, liquids, and thermal machines, to more intricate systems such as living organisms and black holes to name a few. …”
Publicado 2019
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775por Makleff, Shelly, Billowitz, Marissa, Garduño, Jovita, Cruz, Mariana, Silva Márquez, Vanessa Ivon, Marston, Cicely“…Despite calls for evaluation practice to take a complex systems approach, there are few examples of how to incorporate complexity into real-life evaluations. …”
Publicado 2020
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776por Dittami, Simon M., Arboleda, Enrique, Auguet, Jean-Christophe, Bigalke, Arite, Briand, Enora, Cárdenas, Paco, Cardini, Ulisse, Decelle, Johan, Engelen, Aschwin H., Eveillard, Damien, Gachon, Claire M.M., Griffiths, Sarah M., Harder, Tilmann, Kayal, Ehsan, Kazamia, Elena, Lallier, François H., Medina, Mónica, Marzinelli, Ezequiel M., Morganti, Teresa Maria, Núñez Pons, Laura, Prado, Soizic, Pintado, José, Saha, Mahasweta, Selosse, Marc-André, Skillings, Derek, Stock, Willem, Sunagawa, Shinichi, Toulza, Eve, Vorobev, Alexey, Leblanc, Catherine, Not, Fabrice“…The holobiont concept is a renewed paradigm in biology that can help to describe and understand these complex systems. It posits that a host and its associated microbiota with which it interacts, form a holobiont, and have to be studied together as a coherent biological and functional unit to understand its biology, ecology, and evolution. …”
Publicado 2021
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777“…Various complex systems, such as the climate, ecosystems, and physical and mental health can show large shifts in response to small changes in their environment. …”
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778por Shah, Nikhil, Mathew, Sharon, Pereira, Amanda, Nakaima, April, Sridharan, Sanjeev“…Methods: This paper is informed by reviews of the literature on QoC and the roles of evaluation in complex systems. The proposed framework synthesizes the multiple views of QoC. …”
Publicado 2021
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779por Silverman, Eric, Gostoli, Umberto, Picascia, Stefano, Almagor, Jonatan, McCann, Mark, Shaw, Richard, Angione, Claudio“…In an effort to clearly illustrate the utility of ABM for population health research, and to clear up persistent misunderstandings regarding the method’s conceptual underpinnings, we offer a detailed presentation of the core concepts of complex systems theory, and summarise why simulations are essential to the study of complex systems. …”
Publicado 2021
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780por Weyandt, Elisabeth, Leanza, Luigi, Capelli, Riccardo, Pavan, Giovanni M., Vantomme, Ghislaine, Meijer, E. W.“…Our combined experimental and theoretical approach allows for precise control of molecular self-assembly and chiral discrimination in complex systems.…”
Publicado 2022
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