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321por Czarnecki, Damian, Ziółkowski, Marcin, Chodkiewicz, Jan, Długosz, Anna, Feldheim, Joanna, Waszkiewicz, Napoleon, Kułak-Bejda, Agnieszka, Gorzkiewicz, Marta, Budzyński, Jacek, Junkiert-Czarnecka, Anna, Siomek-Górecka, Agnieszka, Nicpoń, Krzysztof, Kawala-Sterniuk, Aleksandra, Ferri, Raffaele, Pelc, Mariusz, Walecki, Piotr, Laskowska, Ewa, Gorzelańczyk, Edward Jacek“…The main aim of this work was to determine the impact of COMT and DRD2 gene polymorphisms together with temperament and character traits on alcohol craving severity alcohol-dependent persons. …”
Publicado 2021
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322“…Catechol-O-methyltransferase (COMT) encodes an enzyme that is highly expressed in sensory hair cells of the inner ear. …”
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327por Voutilainen, Sari, Tuomainen, Tomi-Pekka, Korhonen, Maarit, Mursu, Jaakko, Virtanen, Jyrki K., Happonen, Pertti, Alfthan, Georg, Erlund, Iris, North, Kari E., Mosher, M.J., Kauhanen, Jussi, Tiihonen, Jari, Kaplan, George A., Salonen, Jukka T.“…Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met) in the Catechol-O-methyltransferase (COMT) gene. METHODOLOGY AND FINDINGS: Our aim was to examine the role of COMT Val158Met polymorphism and interaction of this polymorphism with serum tHcy and folate concentration on the risk of acute coronary and events in middle-aged men from eastern Finland. …”
Publicado 2007
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328por Qian, Qiu-Jin, Liu, Jin, Wang, Yu-Feng, Yang, Li, Guan, Li-Li, Faraone, Stephen V“…CONCLUSION: Our study of attention deficit hyperactivity disorder comorbid oppositional defiant disorder and its predominately inattentive type highlights the potential etiologic role of COMT for ADHD children in China. But we failed to observe an interaction between COMT and MAOA, which suggests that epistasis between COMT and MAOA genes does not influence the phenotype of ADHD-IA with comorbid ODD in a clinical sample of Chinese male subjects. …”
Publicado 2009
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329“…CONCLUSION: A cumulative risk allele count involving four single nucleotide polymorphisms located within the FKBP5, COMT, CHRNA5, and CRHR1 genes are associated with PTSD. …”
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330“…High doses of Halowax 1051 were inhibitory to COMT and SULT1A activity and reduced their protein levels. …”
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331por Ho, Philip Wing-Lok, Tse, Zero Ho-Man, Liu, Hui-Fang, Lu, Song, Ho, Jessica Wing-Man, Kung, Michelle Hiu-Wai, Ramsden, David Boyer, Ho, Shu-Leong“…We previously demonstrated that catechol-O-methyltransferase (COMT) is transcriptionally regulated by estrogen via estrogen receptor (ER). …”
Publicado 2013
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332por Ramsay, Hugh, Kelleher, Ian, Flannery, Padraig, Clarke, Mary C., Lynch, Fionnuala, Harley, Michelle, Connor, Dearbhla, Fitzpatrick, Carol, Morris, Derek W., Cannon, Mary“…METHOD: Psychiatric interviews and genotyping for COMT-Val158Met and BDNF-Val66Met were carried out on two population-based samples of 237 individuals aged 11-15 years. …”
Publicado 2013
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333“…BACKGROUND: The Catechol-O-Methyl Transferase (COMT) gene polymorphism (I/D of C nucleotide at base position 900) has been previously implicated in the development of type 2 diabetes (T2D) and kidney disease. …”
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334por Jiang, Jiangling, Fiocco, Alexandra J., Cao, Xinyi, Jiang, Lijuan, Feng, Wei, Shen, Yuan, Li, Ting, Li, Chunbo“…A total of 104 men and women living in Shanghai were randomized to a multi-domain or a single-domain cognitive training (SDCT) group. COMT rs4818 SNP and the BDNF rs6265 SNP were analyzed from blood. …”
Publicado 2018
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335“…The results showed that silencing of COMT1 aggravated heat stress by inhibiting both the light reactions and the carbon fixation reactions of photosynthesis. …”
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336“…Pup weights, crown to rump lengths and abdominal circumferences were reduced in COMT(−/−) mice. Treatment with ATI-5261 did not alter these fetal measurements but significantly reduced placental weights and increased fetal to placental ratios in COMT(−/−) mice. …”
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337por Lu, Nan, Ma, Wenjun, Han, Donghua, Liu, Ying, Wang, Zhi, Wang, Nan, Yang, Guijuan, Qu, Guanzheng, Wang, Qiuxia, Zhao, Kun, Wang, Junhui“…COMTs are associated with the wood properties of forest trees; however, little known about the COMT family in Catalpa bungei, a valuable timber tree species in China . …”
Publicado 2019
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338por Morozova, Anna, Zorkina, Yana, Pavlov, Konstantin, Pavlova, Olga, Storozheva, Zinaida, Zubkov, Eugene, Zakharova, Natalia, Karpenko, Olga, Reznik, Alexander, Chekhonin, Vladimir, Kostyuk, Georgiy“…We investigated the associations of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A with youth-onset schizophrenia in the Russian population in a case–control study, and the role of the genotype in the severity of clinical features. …”
Publicado 2019
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339“…Moreover, this indirect link was moderated by the COMT gene rs4680 polymorphism. Specifically, the risk effect of parent-adolescent conflict on adolescent NSSI via depressive symptoms was stronger for adolescents with Val/Val genotype than for those with Met/Met or Val/Met genotype. …”
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340por Merkulova, T., Chuprova, N., Solovieva, M., Nikolishin, A., Kibitov, A., Grechany, S., Baranok, N., Rybakova, K., Soldatkin, V., Yakovlev, A., Trusova, A., Ponizovsky, P., Krupitsky, E.“…The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used for assessing ACE. COMT Val158Met polymorphism was detected by RT-PCR. …”
Publicado 2022
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