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  1. 1261
    “…Autophagy and glycolysis are highly conserved biological processes involved in both physiological and pathological cellular programs, but the interplay between these processes is poorly understood. …”
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    ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation
  2. 1262
    “…This suggests that, despite the low degree of sequence conservation, many lncRNAs play functionally conserved biological roles.…”
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    Computational Prediction of Polycomb-Associated Long Non-Coding RNAs
  3. 1263
    por Kim, Nayun
    Publicado 2019
    “…Even though the chemistry of this remarkable DNA structure has been under investigation for decades, evidence supporting the biological relevance of G4 DNA has only begun to emerge and point to very important and conserved biological functions. This review will specifically focus on the interplay between transcription and G4 DNA and discuss two alternative but interconnected perspectives. …”
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    The Interplay between G-quadruplex and Transcription
  4. 1264
    “…An alternative form of pest control is conservation biological control (CBC)—a form of ecological pest management—that can reduce the severity of pest outbreaks and crop damage. …”
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    Local and Landscape Effects to Biological Controls in Urban Agriculture—A Review
  5. 1265
    “…We found that solid tumors and hematological malignancies (n = 4179) share conserved biological patterns, and biological network complexity decreases at increasing TcB levels. …”
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    An Analysis of Transcriptomic Burden Identifies Biological Progression Roadmaps for Hematological Malignancies and Solid Tumors
  6. 1266
    “…TGF-β signaling pathways are present in diverse animal species, which indicates their evolutionary importance in modulating several conserved biological processes and maintaining host homeostasis by adjusting the activity of innate immune mechanisms. …”
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    Functional role of the TGF-β signaling in the Drosophila immune response
  7. 1267
    por Green, M. L., Karp, P. D.
    Publicado 2006
    “…For each method we employed, a pair of genes randomly selected from a BioCyc pathway is more likely to be related by that method than is a pair of genes randomly selected from a KEGG pathway, supporting the conclusion that the BioCyc pathway conceptualization is closer to a single conserved biological process than is that of KEGG.…”
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    The outcomes of pathway database computations depend on pathway ontology
  8. 1268
    por Zeng, Xian, Ju, Dianwen
    Publicado 2018
    “…Unfortunately, Hh inhibition fails to show satisfactory benefits in these cancer types compared with the success stories in BCC, highlighting the need for better understanding of Hh signaling in cancer. Autophagy, a conserved biological process for cellular component elimination, plays critical roles in the initiation, progression, and drug resistance of cancer, and therefore, implied potential to be targeted. …”
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    Hedgehog Signaling Pathway and Autophagy in Cancer
  9. 1269
    por Broom, Leon J.
    Publicado 2019
    “…Dysregulated inflammatory responses can be detrimental but, being a highly conserved biological process, inflammation is critical for host defence. …”
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    Host–Microbe Interactions and Gut Health in Poultry—Focus on Innate Responses
  10. 1270
    “…These findings shed light on the sequence correlates of a highly conserved biological process, and improve in silico prediction of 3' mRNA cleavage and polyadenylation sites.…”
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    Similarities and differences of polyadenylation signals in human and fly
  11. 1271
    “…Here we demonstrate the value of the PRO framework in the investigation of the spindle checkpoint, a highly conserved biological process that relies extensively on protein modification and protein complex formation. …”
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    Use of the Protein Ontology for Multi-Faceted Analysis of Biological Processes: A Case Study of the Spindle Checkpoint
  12. 1272
    “…These results suggest that conservation biological control method based on tree species mixtures might help to reduce the impact of the Asian chestnut gall.…”
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    Tree Diversity Limits the Impact of an Invasive Forest Pest
  13. 1273
    “…Directed evolution is a powerful tool in Synthetic Biology, able to bypass gaps in knowledge and capable of engineering even the most highly conserved biological processes. It encompasses a range of methodologies to create variation in a population and to select individual variants with the desired function–be it a ligand, enzyme, pathway or even whole organisms. …”
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    Selection platforms for directed evolution in synthetic biology
  14. 1274
    “…Over the last decade, an increased appreciation for the highly conserved biology among vertebrates and the ability to perform high-throughput drug screening has seen an explosion in the use of zebrafish for disease modeling and drug discovery. …”
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    Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics
  15. 1275
    “…These results are significant because they challenge the paradigm for the use of these drugs as anticancer agents and reveal a connection to UPR, a conserved biological response that has been implicated in tumor growth and response to therapy. …”
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    Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus
  16. 1276
    “…The nematode Caenorhabditis elegans constitutes a leading animal model to study how signaling pathway components function in conserved biological processes. Here, we describe the role of an Axin family member, PRY-1, in lipid metabolism. …”
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    PRY-1/Axin signaling regulates lipid metabolism in Caenorhabditis elegans
  17. 1277
    “…Autophagy is a conserved biological process that maintains cell homeostasis by targeting macromolecules for lysosome-mediated degradation. …”
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    A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation
  18. 1278
    “…We identify which three-dimensional features most potently influence intracellular signaling and distinguish between conserved biological principles that are maintained across culture conditions and cellular behaviors that are sensitive to microenvironmental context. …”
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    Deconstructing Signaling in Three Dimensions
  19. 1279
    por Koonin, Eugene V.
    Publicado 2016
    “…The sequences with fuzzy meaning can be recruited for various functions, with the meaning subsequently fixed, and also could perform generic functional roles that do not require sequence conservation. Biological meaning is continuously transferred between the genomes of selfish elements and hosts in the process of their coevolution. …”
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    The meaning of biological information
  20. 1280
    “…This integrated approach could improve nutrition while conserving biological and cultural diversity.…”
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    Wild Food Plants and Trends in Their Use: From Knowledge and Perceptions to Drivers of Change in West Sumatra, Indonesia
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