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  1. 2961
    “…Further in vitro studies in the COS-7cell line demonstrated that the mutation of ASP119ASN had no impact on protein expression, but decreased the enzyme activity, and with which the clinical significance of Asp119Asn can be determined to be likely pathogenic. …”
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    Clinical and Molecular Characterization of Patients with Fructose 1,6-Bisphosphatase Deficiency
  2. 2962
    “…In vitro, the vaccine transfected COS-7 cells and expressed the proteins corresponding to the genes carried in the vaccine. …”
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    DNA plasmid vaccine carrying Chlamydia trachomatis (Ct) major outer membrane and human papillomavirus 16L2 proteins for anti-Ct infection
  3. 2963
    “…Also, serum chitotriosidase significantly correlated with clinical outcome status (COS) categories (ρ =0.272, P =0.001). CONCLUSIONS: Serum chitotriosidase proved to be a reliable biomarker of sarcoidosis activity and disease chronicity.…”
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    Verifying Sarcoidosis Activity: Chitotriosidase versus ACE in Sarcoidosis – a Case-control Study
  4. 2964
    “…In addition, the transient expression of different mutations was analysed in COS-7 cells. The results obtained, together with those of bioinformatic studies, revealed these mutations to affect the splicing process, the stability of GTP, or the ability of this protein to correctly localise in the ER membrane. …”
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    DPAGT1-CDG: Functional analysis of disease-causing pathogenic mutations and role of endoplasmic reticulum stress
  5. 2965
    “…Only a negligible effect was observed on viability of COS-7 African green monkey kidney fibroblast, a normal cell line notoverexpressing the hyaluronic acid receptor. …”
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    Smart Release Nano-formulation of Cytochrome C and Hyaluronic Acid Induces Apoptosis in Cancer Cells
  6. 2966
    “…Purified recombinant 3MST and lysates of COS cells expressing 3MST showed that Cys-SSH and GSSH were produced in the presence of physiological concentrations of cysteine and glutathione, while those with longer sulfur chains, Cys-SS(n)H and GSS(n)H, were produced in the presence of lower than physiological concentrations of cysteine and glutathione. …”
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    3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H(2)S(2), H(2)S(3) and H(2)S
  7. 2967
    “…Using whole‐cell patch‐clamp electrophysiology in human pulmonary artery smooth muscle and COS7 cell lines, we determined that homomeric and heterodimeric mutant channels in heterozygous KCNK3 conditions lead to mutation‐specific severity of channel dysfunction. …”
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    The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery
  8. 2968
    por Hirbawi, Jamila, Kalafatis, Michael
    Publicado 2017
    “…As a consequence, we produced a recombinant hfV (rhfV) molecule with the substitution (700)NR(701)→DE. rhfV(NR→DE) together with the wild-type molecule (rhfV(WT)) were expressed in COS7 cells, purified, and tested for their capability to function within prothrombinase. …”
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    Spellbinding Effects of the Acidic COOH-Terminus of Factor Va Heavy Chain on Prothrombinase Activity and Function
  9. 2969
    “…Mahdavi) and bean (Phaseoulus vulgaris cv. COS16) in sandy loam and clay loam soils under greenhouse conditions. …”
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    Soil salinity and matric potential interaction on water use, water use efficiency and yield response factor of bean and wheat
  10. 2970
    “…The disorganized cytoskeleton stimulated by cytochalasin D in COS7 cells was dramatically restored by co-transfection with phosphorylated CD16/7-nephrin and c-Abl full-length constructs. …”
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    Role of c-Abl and nephrin in podocyte cytoskeletal remodeling induced by angiotensin II
  11. 2971
    “…The cell-permeable B2R antagonists had less to no anticancer effects on B2R shRNA-knockdown or non-B2R expressing (COS-1) cells, indicating specificity in their action. …”
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    Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer
  12. 2972
    “…Hence, the GA733–2 cDNA was cloned and the specificity of FU‐MK‐1 was confirmed using four recombinant forms of the GA733–2 antigen expressed in COS‐1 cells. Immunoprecipitation with FU‐MK‐1 of the cell lysate transfected with the full‐length GA733–2 cDNA revealed two bands corresponding to those obtained from the tumor cell lines. …”
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    Molecular Identification of a Human Carcinoma‐associated Glycoprotein Antigen Recognized by Mouse Monoclonal Antibody FU‐MK‐1
  13. 2973
    “…MYO3A-L697W showed reduced filopodial actin protrusion initiation in COS7 cells, and a predominant tipward accumulation at filopodia and stereocilia when coexpressed with wild-type MYO3A and espin-1, an actin-regulatory MYO3A cargo. …”
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    Characterization of a novel MYO3A missense mutation associated with a dominant form of late onset hearing loss
  14. 2974
    “…We provided an overview of the types of outcomes reported in HD studies and identified a list of potentially relevant outcomes required for the development of a COS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00384-018-3046-2) contains supplementary material, which is available to authorized users.…”
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    Towards a core outcome set for hemorrhoidal disease—a systematic review of outcomes reported in literature
  15. 2975
    “…Compound D19 showed higher transfection efficiency to transfect BHK-21 and Cos-7 cell lines, when transfecting active proliferating cells. …”
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    Synthesis and Comparative Evaluation of Novel Cationic Amphiphile C12-Man-Q as an Efficient DNA Delivery Agent In Vitro
  16. 2976
    “…Accordingly, we studied the effect of tRNA(Pyl) on live-cell fluorescence imaging of bioorthogonally-labelled intracellular proteins. We found that in COS7 cells, a decrease in PylT copy numbers had no measurable effect on protein expression levels. …”
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    Live Cell Imaging of Bioorthogonally Labelled Proteins Generated With a Single Pyrrolysine tRNA Gene
  17. 2977
    “…BPR1J373 also induced cell cycle arrest and senescent change in KIT‐mutant GIST48 cells, probably by targeting aurora kinase A. In the KIT‐null COS‐1 cell‐based system, BPR1J373 effectively inhibited KIT with single or double mutations of KIT developed in GIST. …”
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    BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor
  18. 2978
    “…TWIK-1 was shown to associate with TASK-3 in DGGCs of mouse hippocampus and when both genes were overexpressed in COS-7 cells. shRNA-mediated gene silencing demonstrated that TWIK-1/TASK-3 heterodimeric channels displayed outwardly rectifying currents and contributed to the intrinsic excitability of DGGCs. …”
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    TWIK-1/TASK-3 heterodimeric channels contribute to the neurotensin-mediated excitation of hippocampal dentate gyrus granule cells
  19. 2979
    “…Patch clamp functional studies using transfected COS-7 cells show that hERG-ΔQ1068 has a mixed phenotype, with both gain- (negative voltage shift of steady-state activation curve, the positive shift of the steady-state inactivation curve, and accelerated activation) and loss-of function (reduced current density, reduced surface expression and accelerated deactivation) hallmarks. …”
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    Molecular autopsy: using the discovery of a novel de novo pathogenic variant in the KCNH2 gene to inform healthcare of surviving family
  20. 2980
    “…The etched products, which composed of porous WS(2), CoS(2) and a spot of WO(x), show a low overpotential and small Tafel slope in 0.5 M H(2)SO(4) solution. …”
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    Multivariate Control of Effective Cobalt Doping in Tungsten Disulfide for Highly Efficient Hydrogen Evolution Reaction
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