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  1. 3101
    “…In the present study, we confirm this peculiar behavior of R539W and suggest a molecular mechanism underlying it. METHODS AND RESULTS: COS-7 cells were transfected with WT or mutated KCNE1-KCNQ1 channel, and patch-clamp recordings were performed in giant-patch, permeabilized-patch or ruptured-patch configuration. …”
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    A Long QT Mutation Substitutes Cholesterol for Phosphatidylinositol-4,5-Bisphosphate in KCNQ1 Channel Regulation
  2. 3102
    “…Here, using bioluminescence resonance energy transfer (BRET), we tested whether RGS2 and RGS4 bind to PAR1 in live COS-7 cells to regulate PAR1/Gα-mediated signaling. …”
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    Regulator of G Protein Signaling 2 (RGS2) and RGS4 Form Distinct G Protein-Dependent Complexes with Protease Activated-Receptor 1 (PAR1) in Live Cells
  3. 3103
    “…The Ile604Asn mutation, located in KL2 domain, was predicted to impair klotho protein stability and in vitro expression studies in COS-7 cells revealed endoplasmic reticulum retention of the Ile604Asn mutant. …”
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    N-ethyl-N-Nitrosourea (ENU) Induced Mutations within the Klotho Gene Lead to Ectopic Calcification and Reduced Lifespan in Mouse Models
  4. 3104
    “…Using the coupled transcription/translation system (TNT), the best results were obtained for SMPD1 mutations with G418, reaching a 35% recovery at 0.25 μg/ml, for the p.W168X mutation. The use of COS cells transfected with mutant cDNAs gave positive results for most of the mutations with some of the drugs, although to a different extent. …”
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    Evaluation of Aminoglycoside and Non-Aminoglycoside Compounds for Stop-Codon Readthrough Therapy in Four Lysosomal Storage Diseases
  5. 3105
    “…In this study, we investigated if cfDNA levels in follicular fluid (FF) samples from in vitro fertilization (IVF) patients, could be related to their ovarian reserve status, controlled ovarian stimulation (COS) protocols and IVF outcomes. Therefore, 117 FF samples were collected from women (n = 117) undergoing IVF/Intra-cytoplasmic sperm injection (ICSI) procedure and cfDNA concentration was quantified by ALU-quantitative PCR. …”
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    Cell-free DNA in Human Follicular Microenvironment: New Prognostic Biomarker to Predict in vitro Fertilization Outcomes
  6. 3106
    “…The reaction of 1 with COS forms a thermally unstable complex 9 that undergoes scission to give mono(μ-S) mono(CO) species 10. …”
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    The Reductive Activation of CO(2) Across a Ti=Ti Double Bond: Synthetic, Structural, and Mechanistic Studies
  7. 3107
    “…EXPERIMENTAL APPROACH: Transiently transfected COS‐7 cells were assessed for cAMP accumulation upon ligand stimulation and assayed in competition binding using (125)I‐human GIP. …”
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    Species‐specific action of (Pro3)GIP – a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors
  8. 3108
    “…When an N‐terminal fragment of PGC‐1α was cotransfected with its partner transcription factor ERR α (estrogen‐related receptor‐α) in COS‐7 cells, COA‐Cl upregulated the expression of the endogenous VEGF mRNA. …”
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    A key role of PGC‐1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA‐Cl in cultured human fibroblasts
  9. 3109
    “…Gastroprotection by CORM-2 and HO depends upon CO’s hyperemic and anti-inflammatory properties, but is independent of NO.…”
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    The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO)
  10. 3110
    “…The ability of antibodies to inhibit DBL-TH-erythrocyte binding was tested by COS7 erythrocyte binding inhibition assay. Seven samples of high responders (HR) were identified from screening anti-DBPII levels. …”
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    Strain-Transcending Inhibitory Antibodies against Homologous and Heterologous Strains of Duffy Binding Protein region II
  11. 3111
    “…Patch‐clamp experiments performed in COS‐7 cells expressing both Kv4.3 and Kvβ2 revealed a significant increase in the current density in presence of the R12Q and L13F Kvβ2 mutants. …”
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    Dysfunction of the Voltage‐Gated K(+) Channel β2 Subunit in a Familial Case of Brugada Syndrome
  12. 3112
    “…Furthermore, in cell transfection assays using Cryga(Secc) mutant cDNA expression constructs in 293T, COS-7 and human lens epithelial B3 cell lines, the mutant γA-crystallins were enriched in the insoluble fractions and appeared as insoluble aggregates in the transfected cells. …”
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    A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid
  13. 3113
    “…Second, listed databases for published literature (MEDLINE, Tripdatabase, Pedro, EMBASE, the Cochrane Central Register of Controlled Trials and WoS) and unpublished literature (Open Grey, Current Controlled Trials, MedNar, ClinicalTrials.gov, Cos Conference Papers Index and International Clinical Trials Registry Platform of the WHO) will be queried. …”
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    Comparing the accuracy of quantitative versus qualitative analyses of interim PET to prognosticate Hodgkin lymphoma: a systematic review protocol of diagnostic test accuracy
  14. 3114
    “…A further four known genotypes (CD6, COS-I, BEB6, and J) and 22 novel genotypes (CHG1–CHG3, CHG5, CHG8, CHG10–CHG14, CHG16–CHG18, CHG20, CHG22, CHG24, CHS3, CHS4 and CHS6–CHS9) formed a clade within the group 2. …”
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    Molecular survey of Enterocytozoon bieneusi in sheep and goats in China
  15. 3115
    “…Mutated proteins were transiently expressed in COS-1 cells and enzyme activities towards 17-hydroxyprogesterone and progesterone were determined. …”
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    Functional and Structural Consequences of Nine CYP21A2 Mutations Ranging from Very Mild to Severe Effects
  16. 3116
    “…Ectopic expression of SeoC/SboC inhibited phagocytosis of IgG-opsonized beads into Cos-7 cells stably expressing green fluorescent protein (GFP)-FcγRIIa. …”
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    The Type III Secretion System Effector SeoC of Salmonella enterica subsp. salamae and S. enterica subsp. arizonae ADP-Ribosylates Src and Inhibits Opsonophagocytosis
  17. 3117
    “…We found that the isomerization-dependent drop in effective 2-AG concentration caused only a weak diminution of Ca(2+) signaling in CB1 transfected COS7 cells. We also found that 1-AG induces Ca(2+) transients through the activation of CB1, but its working concentration is threefold higher than that of 2-AG. …”
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    The Ratio of 2-AG to Its Isomer 1-AG as an Intrinsic Fine Tuning Mechanism of CB1 Receptor Activation
  18. 3118
    “…A positive Cross-over (COS) and Posterior Wall (PW) sign were present in 60% of hips, and the mean Tonnis angle was 3.2 deg. …”
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    The Dancers Hip: The Hyperflexible Athlete: Anatomy & Arthroscopic Clinical Outcomes
  19. 3119
    “…Four tumor motion patterns were simulated with cos(4)(x) and sin(x), each with 2 different amplitudes: 10 mm and 5 mm. …”
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    Dosimetric Analysis of Microscopic Disease in SBRT for Lung Cancers
  20. 3120
    “…Here we use regression analysis to quantify the relationships between kinetic parameters obtained from empirical data sets spanning a wide evolutionary range of RuBisCOs. Most significantly we found that the rate constant for dissociation of CO(2) from the enzyme complex was much higher than previous estimates and comparable with the corresponding catalytic rate constant. …”
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    Directions for Optimization of Photosynthetic Carbon Fixation: RuBisCO's Efficiency May Not Be So Constrained After All
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