A representative metalloprotease induces PGE(2) synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

por Viana, Mariana N., Leiguez, Elbio, Gutiérrez, José M., Rucavado, Alexandra, Markus, Regina P., Marçola, Marina, Teixeira, Catarina, Fernandes, Cristina M.
Publicado 2020

Upregulation of PD-L1 Expression by Prostaglandin E(2) and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection

por Goto, Shinya, Konnai, Satoru, Hirano, Yuki, Kohara, Junko, Okagawa, Tomohiro, Maekawa, Naoya, Sajiki, Yamato, Watari, Kei, Minato, Erina, Kobayashi, Atsuhi, Gondaira, Satoshi, Higuchi, Hidetoshi, Koiwa, Masateru, Tajima, Motoshi, Taguchi, Eiji, Uemura, Ryoko, Yamada, Shinji, Kaneko, Mika K., Kato, Yukinari, Yamamoto, Keiichi, Toda, Mikihiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
Publicado 2020

Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli

por Piasecka, Dominika, Braun, Marcin, Mieszkowska, Magdalena, Kowalczyk, Lukasz, Kopczynski, Janusz, Kordek, Radzislaw, Sadej, Rafal, Romanska, Hanna M.
Publicado 2020

PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1)

por Luo, Peihua, Yan, Hao, Du, Jiangxia, Chen, Xueqin, Shao, Jinjin, Zhang, Ying, Xu, Zhifei, Jin, Ying, Lin, Nengming, Yang, Bo, He, Qiaojun
Publicado 2020

Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE(2) Pathway

por Tsai, Ming-Ming, Lin, Horng-Chyuan, Yu, Ming-Chin, Lin, Wan-Jung, Chu, Mei-Yi, Tsai, Ching-Ching, Cheng, Ching-Yi
Publicado 2021

COX-2/sEH Dual Inhibitor PTUPB Attenuates Epithelial-Mesenchymal Transformation of Alveolar Epithelial Cells via Nrf2-Mediated Inhibition of TGF-β1/Smad Signaling

por Zhang, Chen-Yu, Guan, Xin-Xin, Song, Zhuo-Hui, Jiang, Hui-Ling, Liu, Yu-Biao, Chen, Ping, Duan, Jia-Xi, Zhou, Yong
Publicado 2022

Development of machine learning models integrating PET/CT radiomic and immunohistochemical pathomic features for treatment strategy choice of cervical cancer with negative pelvic lymph node by mediating COX-2 expression

por Zhang, Zhe, Li, Xiaoran, Sun, Hongzan
Publicado 2022

Triple targeting of mutant EGFR(L858R/T790M), COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation

por Kothayer, Hend, Rezq, Samar, Abdelkhalek, Ahmed S., Romero, Damian G., Elbaramawi, Samar S.
Publicado 2023

Time to postpartum family planning initiation and its predictors among mothers coming for first measles vaccination at Family Guidance Association of Ethiopia, Dessie Model Clinic, Northeast Ethiopia: cox-regression model

por Adane, Bezawit, Addisu, Elsabeth, Yalew, Melaku, Damtie, Yitayish, Arefaynie, Mastewal, Zewdie, Segenet, Wasihun, Yitbarek, Kefale, Bereket
Publicado 2023

Oleifolioside A, a New Active Compound, Attenuates LPS-Stimulated iNOS and COX-2 Expression through the Downregulation of NF-κB and MAPK Activities in RAW 264.7 Macrophages

por Yu, Hai Yang, Kim, Kyoung-Sook, Lee, Young-Choon, Moon, Hyung-In, Lee, Jai-Heon
Publicado 2012

Ginsenoside Rp(1), a Ginsenoside Derivative, Blocks Promoter Activation of iNOS and COX-2 Genes by Suppression of an IKKβ-mediated NF-кB Pathway in HEK293 Cells

por Shen, Ting, Lee, Jaehwi, Park, Myung Hwan, Lee, Yong Gyu, Rho, Ho Sik, Kwak, Yi-Seong, Rhee, Man Hee, Park, Yung Chul, Cho, Jae Youl
Publicado 2011

MMP1, MMP9, and COX2 Expressions in Promonocytes Are Induced by Breast Cancer Cells and Correlate with Collagen Degradation, Transformation-Like Morphological Changes in MCF-10A Acini, and Tumor Aggressiveness

por Chimal-Ramírez, G. K., Espinoza-Sánchez, N. A., Utrera-Barillas, D., Benítez-Bribiesca, L., Velázquez, J. R., Arriaga-Pizano, L. A., Monroy-García, A., Reyes-Maldonado, E., Domínguez-López, M. L., Piña-Sánchez, Patricia, Fuentes-Pananá, E. M.
Publicado 2013

TGF-β1 Downregulates COX-2 Expression Leading to Decrease of PGE2 Production in Human Lung Cancer A549 Cells, Which Is Involved in Fibrotic Response to TGF-β1

por Takai, Erina, Tsukimoto, Mitsutoshi, Kojima, Shuji
Publicado 2013