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  1. 241
    “…Cyclooxygenase-2 (COX-2) is an enzyme involved in inflammation. The overexpression of COX-2 causes chronic inflammation, which can be prevented by COX-2 inhibitors. …”
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    Bioactivity of dihydropyrimidinone derivatives as inhibitors of cyclooxygenase-2 (COX-2): an in silico approach
  2. 242
    por Einhorn, Thomas A
    Publicado 2003
    “…Data from animal studies suggest that both non-specific and specific inhibitors of cyclooxygenases impair fracture healing but that this is due to the inhibition of COX-2 and not COX-1. Although these data raise concerns about the use of COX-2-specific inhibitors as anti-inflammatory or anti-analgesic drugs in patients undergoing bone repair, clinical reports have been inconclusive. …”
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    Cox-2: Where are we in 2003? - The role of cyclooxygenase-2 in bone repair
  3. 243
    por Day, Richard
    Publicado 2003
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    COX-2: Where are we in 2003? - Distinction from NSAIDs becoming blurred
  4. 244
    “…Genetic and pharmacological inhibition of COX-2, but not COX-1, blocked arginase I induction in vitro and in vivo. …”
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    Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
  5. 245
    por Howes, Laurence Guy
    Publicado 2007
    “…Inhibitors of cyclo-oxogenase (COX) are widely used anti-inflammatory drugs. In recent years concerns have arisen about the cardiovascular safety of these drugs, initially because of reported associations between therapy with the COX-2 selective inhibitor rofecoxib and myocardial infarction. …”
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    Selective COX-2 inhibitors, NSAIDs and cardiovascular events – is celecoxib the safest choice?
  6. 246
    por Yao, M, Song, D H, Rana, B, Wolfe, M M
    Publicado 2002
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    COX-2 selective inhibition reverses the trophic properties of gastrin in colorectal cancer
  7. 247
    “…Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. …”
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    Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
  8. 248
    “…We examined the effects of progesterone or cyclo-oxygenase 2 (Cox2) inhibitor treatments on the PRA/PRB ratio in silico. …”
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    A Computer Simulation of Progesterone and Cox2 Inhibitor Treatment for Preterm Labor
  9. 249
    por Borer, Jeffrey S, Simon, Lee S
    Publicado 2005
    “…In response to the adverse effects that can accompany nonselective NSAID use, selective cyclo-oxygenase (COX)-2 inhibitors were developed to target the COX-2 isoenzyme, thus providing anti-inflammatory and analgesic benefits while theoretically sparing the gastroprotective activity of the COX-1 isoenzyme. …”
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    Cardiovascular and gastrointestinal effects of COX-2 inhibitors and NSAIDs: achieving a balance
  10. 250
    “…We collected fecal samples from 21 individuals infected with Taenia tapeworms in Koh Kong Province, Cambodia, and performed nucleotide sequencing of the cox1 gene and multiplex PCR on the eggs for DNA differential diagnosis of human Taenia tapeworms. …”
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    Molecular Identification of Taenia Tapeworms by Cox1 Gene in Koh Kong, Cambodia
  11. 251
    “…We tested this hypothesis on three recombinant mouse models characterized by defective cytochrome c-oxidase (COX) activity: a knockout (KO) mouse for Surf1, a knockout/knockin mouse for Sco2, and a muscle-restricted KO mouse for Cox15. …”
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    In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
  12. 252
    “…This review concluded that, both NSAIDs and COX-2 inhibitors are equally effective and are associated with increased risk of GI, renal, and CV, adverse effects. …”
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    Efficacy and Safety of COX-2 Inhibitors in the Clinical Management of Arthritis: Mini Review
  13. 253
    “…In addition, EP1 and EP3 are important in the Cox-2-induced invasion of MCF-7/DOX cells. Therefore, not only Cox-2 but also EP1 and EP3 could be important targets for chemosensitization and inhibition of metastasis in breast cancers that are resistant to chemotherapy.…”
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    Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells
  14. 254
    “…Original data were transformed using an extension of the Box–Cox transformation to approach normality and to estimate (co)variance components. …”
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    Box–Cox Transformation and Random Regression Models for Fecal egg Count Data
  15. 255
    “…The cellular and molecular events responsible for reduced fracture healing with aging are unknown. Cyclooxygenase 2 (COX-2), the inducible regulator of prostaglandin E(2) (PGE(2)) synthesis, is critical for normal bone repair. …”
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    Reduced COX-2 Expression in Aged Mice Is Associated With Impaired Fracture Healing
  16. 256
    “…BACKGROUND: When a medicine such as rofecoxib (Vioxx) is withdrawn, or a whole class of medicines discredited such as the selective COX-2 inhibitors (COX-2s), follow-up of impacts at consumer level can be difficult and costly. …”
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    An observational study of the discrediting of COX-2 NSAIDs in Australia: Vioxx or class effect?
  17. 257
    “…MATERIALS AND METHODS: Forty-four patients of SCC were included in the present study and immunohistochemical examination was done for COX-2 expression. Negative and <5% COX-2 positivity were taken as negative expression and ≥5% COX-2 positivity as positive expression group. ≥30% COX-2 positivity was taken as overexpressed group and <30% COX-2 positivity was taken as underexpressed group. …”
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    Overexpression of COX-2 in oral squamous cell carcinoma patients undergoing chemoradiotherapy
  18. 258
    “…Furthermore, we develop a refinement of the compound covariate method by incorporating likelihood information from multivariate Cox models. The new proposal is an adaptive method that borrows information contained in both the univariate and multivariate Cox regression estimators. …”
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    Survival Prediction Based on Compound Covariate under Cox Proportional Hazard Models
  19. 259
    “…The sequence and structural studies reveals Mus musculus COX-2 shares the common conserved sequence and structural pattern with human COX-2. …”
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    COX-2 structural analysis and docking studies with gallic acid structural analogues
  20. 260
    “…COX-2 inhibition may represent a novel immunotherapeutic strategy to control infection with B. pseudomallei and other intracellular pathogens.…”
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    Post-Exposure Therapeutic Efficacy of COX-2 Inhibition against Burkholderia pseudomallei
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