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  1. 261
    “…[Image: see text] Indomethacin is a potent, time-dependent, nonselective inhibitor of the cyclooxygenase enzymes (COX-1 and COX-2). Deletion of the 2′-methyl group of indomethacin produces a weak, reversible COX inhibitor, leading us to explore functionality at that position. …”
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    The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor
  2. 262
    “…However, the viability of COX-2 as a therapeutic target for in vivo eCB augmentation has not been explored. …”
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    Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation
  3. 263
    “…The objective of our present study was to understand the effect of chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., on angiogenesis. …”
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    Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor
  4. 264
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    COX-2 and E-selectin expression evaluation after acute normovolemic hemodilution
  5. 265
    “…While increased COX2 expression and prostaglandin levels are elevated in human cancers, the mechanisms of COX2 regulation at the post-translational level are unknown. …”
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    Post-translational regulation of COX2 activity by FYN in prostate cancer cells
  6. 266
    “…We conclude that platelets differentially regulate mechanisms of angiogenesis in vivo, likely via COX signalling. Since endothelial proliferation is not impaired, we propose a link between COX1 and induction of endothelial migration.…”
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    In Vivo Evidence for Platelet-Induced Physiological Angiogenesis by a COX Driven Mechanism
  7. 267
    “…BACKGROUND: Overexpression of cyclooxygenase-2 (COX-2) has been implicated in oncogenesis and progression of adenocarcinomas of the pancreatic head. …”
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    COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
  8. 268
    “…Subsequently, molecular docking analysis has been performed to identify compounds having activity against COX-1 and COX-2 enzymes by using GOLD docking fitness. …”
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    Molecular docking and analgesic studies of Erythrina variegata׳s derived phytochemicals with COX enzymes
  9. 269
    por Chu, Ge-Jin, Liang, Yong, Wang, Jia-Xuan
    Publicado 2014
    “…In this paper, we investigate a novel harmonic regularization method, which can approximate nonconvex Lq  (1/2 < q < 1) regularizations, to select key risk factors in the Cox's proportional hazards model using microarray gene expression data. …”
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    Novel Harmonic Regularization Approach for Variable Selection in Cox's Proportional Hazards Model
  10. 270
    “…BACKGROUND: This study was designed to examine a novel role of COX-2/PGE(2) signaling as a regulator of PTPRJ expression in endothelial cells. …”
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    Regulated Expression of PTPRJ by COX-2/PGE(2) Axis in Endothelial Cells
  11. 271
    “…Both of these cholesterol-independent effects result from an apoE3-mediated induction of cyclooxygenase-2 (Cox2). Nevertheless, how apoE3 regulates Cox2 remains unknown. …”
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    Apolipoprotein E3 Inhibits Rho to Regulate the Mechanosensitive Expression of Cox2
  12. 272
    “…Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. …”
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    Ku80 cooperates with CBP to promote COX-2 expression and tumor growth
  13. 273
    “…BACKGROUND: As an induced enzyme, COX-2 expression is elevated under stimuli from inflammatory mediator or growth factor product. …”
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    Expression and Significance of COX-2 and Ki-67 in Hepatolithiasis with Bile Duct Carcinoma
  14. 274
    por Muhammad, Aminu, Sirat, Hasnah Mohd
    Publicado 2013
    “…The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 µM (IC(50) 0.46 µM) compared to the positive control, indomethacin (79.20 %, IC(50) 0.24 µM).…”
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    COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
  15. 275
    “…In this study we hypothesized that COX-1 and COX-2 have differential roles in chondrogenic differentiation. …”
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    The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells
  16. 276
    “…Acetaminophen, an analgesic without COX-2 activity, had no effect. Overexpression of COX-2 and increased prostaglandin biosynthesis correlates with carcinogenesis and metastasis at most anatomic sites. …”
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    Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
  17. 277
    “…Prognostic models based on survival data frequently make use of the Cox proportional hazards model. Developing reliable Cox models with few events relative to the number of predictors can be challenging, even in low-dimensional datasets, with a much larger number of observations than variables. …”
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    Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events
  18. 278
    “…Next, we found an inducible inflammation-related enzyme COX-2 was remarkably enhanced by IS, and the inhibition of COX-2 by NS398 significantly blocked IS-induced MC proliferation in line with a blockade of PGE2 production. …”
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    Indoxyl Sulfate Induces Mesangial Cell Proliferation via the Induction of COX-2
  19. 279
    por Shamsara, Jamal, Shahir-Sadr, Ahmad
    Publicado 2016
    “…Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. …”
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    Developing a CoMSIA Model for Inhibition of COX-2 by Resveratrol Derivatives
  20. 280
    “…This work also proposes that novel strategies to control brucellosis may include the use of COX-2 inhibitors.…”
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    COX-2 Inhibition Reduces Brucella Bacterial Burden in Draining Lymph Nodes
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