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301por Timur, Ufuk Tan, Caron, Marjolein M. J., Jeuken, Ralph M., Bastiaansen-Jenniskens, Yvonne M., Welting, Tim J. M., van Rhijn, Lodewijk W., van Osch, Gerjo J. V. M., Emans, Pieter J.“…Studies investigating OA-related cartilage damage of selective COX-2 inhibitors in vivo were included. Nine of the fourteen preclinical studies demonstrated chondroprotective effects of selective COX-2 inhibitors using systemic administration. …”
Publicado 2020
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302“…Seventeen genes among hub genes were significantly associated with prognosis and used to construct a prognostic model through COX hazard regression analysis. The predictive performance of this model was evaluated with TCGA data and was further validated with independent dataset GSE14520. …”
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303Coupling sparse Cox models with clustering of longitudinal transcriptomics data for trauma prognosis“…To model the length of stay, an initial dimensionality reduction step was performed by applying Cox regression with elastic net regularization using gene expression data from the first hospitalization days. …”
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304“…From in vitro and in vivo studies, we concluded that Iminodibenzyl could reprogram COX-2 induced DGLA peroxidation to produce anti-cancer activity.…”
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306“…Recently, various methods have been proposed for exploring a small prognostic gene set that can distinguish the high-risk group from the low-risk group. METHODS: Regularized Cox proportional hazards (RCPH) models were proposed to discover prognostic biomarkers of BRCA from gene expression data. …”
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307“…BACKGROUND: To evaluate the correlation between COX-2 overexpression and clinicopathological features of gastric cancer, thus providing theoretical basis for anti-COX-2 targeted therapy. …”
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308por Desind, Samuel Z., Iacona, Joseph R., Yu, Christina Y., Mitrofanova, Antonina, Lutz, Carol S.“…Our data suggest that PACER is critically involved in COX-2 transcription and dysregulation in lung cancer cells. …”
Publicado 2022
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309“…[Image: see text] When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. …”
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310por Kamada, Shuhei, Takeiwa, Toshihiko, Ikeda, Kazuhiro, Horie, Kuniko, Inoue, Satoshi“…The relevance of OXPHOS in breast cancer has been recently defined by the discovery of COX7RP, which promotes mitochondrial respiratory supercomplex assembly and glutamine metabolism: the latter is also shown to promote nucleic acid and fatty acid biosynthesis as well as ROS defense regulation. …”
Publicado 2022
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311por Meriwether, David, Jones, Anthony E., Ashby, Julianne W., Solorzano-Vargas, R. Sergio, Dorreh, Nasrin, Noori, Shoreh, Grijalva, Victor, Ball, Andréa B., Semis, Margarita, Divakaruni, Ajit S., Mack, Julia J., Herschman, Harvey R., Martin, Martin G., Fogelman, Alan M., Reddy, Srinivasa T.“…METHODS: Using apoptotic neutrophils and synthetic apoptotic targets, we determined the effects of macrophage specific Cox2 knockout and pharmacological COX2 inhibition on the efferocytosis capacity of mouse primary macrophages. …”
Publicado 2022
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312“…Here, we describe an expansion-based method for rapidly clearing Golgi-Cox-stained tissue. The results show that 1 mm thick Golgi-Cox-stained tissue can be cleared within 6 hours with a well preserved Golgi-Cox-stained signal. …”
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313“…In addition, the lack of Cox7c resulted in the accumulation of intracellular heme B. …”
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314por El-Malah, Afaf A., Gineinah, Magdy M., Deb, Pran Kishore, Khayyat, Ahdab N., Bansal, Monika, Venugopala, Katharigatta N., Aljahdali, Anfal S.“…The introduction of selective COX-2 inhibitors (so-called ‘coxibs’) has demonstrated tremendous commercial success due to their claimed lower potential of serious gastrointestinal adverse effects than traditional NSAIDs. …”
Publicado 2022
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315“…This report examines a rare case of a patient that underwent resection of papillary fibroelastoma with simultaneous Cox-Maze IV procedure for treatment of atrial fibrillation. …”
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316por Kelkka, Tiina, Tyster, Mikko, Lundgren, Sofie, Feng, Xingmin, Kerr, Cassandra, Hosokawa, Kohei, Huuhtanen, Jani, Keränen, Mikko, Patel, Bhavisha, Kawakami, Toru, Maeda, Yuka, Nieminen, Otso, Kasanen, Tiina, Aronen, Pasi, Yadav, Bhagwan, Rajala, Hanna, Nakazawa, Hideyuki, Jaatinen, Taina, Hellström-Lindberg, Eva, Ogawa, Seishi, Ishida, Fumihiro, Nishikawa, Hiroyoshi, Nakao, Shinji, Maciejewski, Jaroslaw, Young, Neal S., Mustjoki, Satu“…We identified a novel autoantibody that binds to the C-terminal end of cyclooxygenase 2 (COX-2, aCOX-2 Ab). In total, 37% of all adult IAA patients tested positive for aCOX-2 Ab, while only 1.7% of the controls were aCOX-2 Ab positive. …”
Publicado 2022
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317“…We describe a treatment‐specific marginal structural Cox model for estimation of the causal effect of treatment discontinuation on a survival endpoint. …”
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318por Mao, Yongxin, Zhuo, Ran, Ma, Wenming, Dai, Jun, Alimu, Parehe, Fang, Chen, Xu, Danfeng, Ye, Lei, Wang, Weiqing, Sun, Fukang“…OBJECTIVE: Our previous work found COX4I2 was associated with angiogenesis in pheochromocytoma. …”
Publicado 2022
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319por Bonneville, Edouard F, Resche-Rigon, Matthieu, Schetelig, Johannes, Putter, Hein, de Wreede, Liesbeth C“…In the latter case, the imputations may be performed either compatibly with a substantive model pre-specified as a cause-specific Cox model [substantive model compatible fully conditional specification (SMC-FCS)], or approximately so [multivariate imputation by chained equations (MICE)]. …”
Publicado 2022
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320por Rius, Rocio, Bennett, Neal K., Bhattacharya, Kaustuv, Riley, Lisa G., Yüksel, Zafer, Formosa, Luke E., Compton, Alison G., Dale, Russell C., Cowley, Mark J., Gayevskiy, Velimir, Al Tala, Saeed M., Almehery, Abdulrahman A., Ryan, Michael T., Thorburn, David R., Nakamura, Ken, Christodoulou, John“…This finding is surprising since COX11 has no known role in CoQ(10) biosynthesis. …”
Publicado 2022
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