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  1. 21
    por Moussa, Nathalie, Dayoub, Ninar
    Publicado 2023
    “…This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal anti-inflammatory drugs (NSAIDs) in the management of AD. …”
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    Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors
  2. 22
    “…Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. …”
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    COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma
  3. 23
    “…Regulation of eukaryotic cytochrome oxidase assembly occurs at the level of Cox1 translation, its central mitochondria-encoded subunit. …”
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    Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria
  4. 24
    “…In this study, we observed a significant down-regulation of COX-2 protein expression in VA-treated A549 cells however COX-2 mRNA levels were unaltered. …”
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    Viscum album-Mediated COX-2 Inhibition Implicates Destabilization of COX-2 mRNA
  5. 25
    “…The conserved mitochondrial-encoded COX1- and COX2-subunits are the heme- and copper-center containing core subunits that catalyze water formation. …”
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    COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis
  6. 26
    “…However, the underlying mechanisms explaining this risk reduction are poorly understood. Both cyclooxygenase (COX)‐1‐ and COX‐2‐dependent effects might be involved. …”
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    Aspirin for the prevention and treatment of pre‐eclampsia: A matter of COX‐1 and/or COX‐2 inhibition?
  7. 27
    “…Familial adenomatous polyposis (FAP) provides a model for sporadic colorectal cancer development. Cyclooxygenase (COX) inhibition may ameliorate polyp development, but rofecoxib was withdrawn due to cardiovascular side effects. …”
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    Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP
  8. 28
    “…COX subunit VIIa polypeptide 2-like protein (COX7AR) is a novel COX subunit that was recently found to be involved in mitochondrial supercomplex assembly and mitochondrial respiration activity. …”
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    COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy
  9. 29
    “…BACKGROUND: Mutations of cyclooxygenase gene (COX gene) may increase the susceptibility of ischemic stroke. …”
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    Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population
  10. 30
    “…In this study, the results from a Cox regression model (CM) and a generalized Cox regression model (GCM) are compared. …”
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    Comparison of Cox proportional hazards regression and generalized Cox regression models applied in dementia risk prediction
  11. 31
    “…Cytochrome-c-oxidase (COX) subunit 4 (COX4) plays important roles in the function, assembly and regulation of COX (mitochondrial respiratory complex 4), the terminal electron acceptor of the oxidative phosphorylation (OXPHOS) system. …”
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    Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency
  12. 32
    “…OBJECTIVE: We aim to quantify the absolute protein expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in various cells and tissues to determine the relative contribution of COX-1 and COX-2 to PGE(2) production. …”
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    Comparison of Absolute Expression and Turnover Number of COX-1 and COX-2 in Human and Rodent Cells and Tissues
  13. 33
    “…COXI administered either during pregnancy or after birth can influence kidney development including nephronogenesis, and can decrease renal perfusion and ultrafiltration potentially leading to acute kidney injury in the newborn period. To date, which COX isoform (COX-1 or COX-2) plays a more important role in during fetal development and influences kidney function early in life is not known, though evidence points to a predominant role for COX-2. …”
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    Cyclooxygenase (COX) Inhibitors and the Newborn Kidney
  14. 34
    por Wang, Zhen, Chen, Jun-qiang, Liu, Jin-lu
    Publicado 2014
    “…The evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer. …”
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    COX-2 Inhibitors and Gastric Cancer
  15. 35
    por Zaqout, Sami, Kaindl, Angela M.
    Publicado 2016
    “…Here, we describe the Golgi-Cox staining in such detail that should turn the staining into an easily feasible method for all scientists working in the neuroscience field.…”
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    Golgi-Cox Staining Step by Step
  16. 36
    “…NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H(2) (PGH(2)) and other prostaglandin (PG) metabolites. …”
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    Adverse Effects of COX-2 Inhibitors
  17. 37
    “…Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandins that play an important role in inflammation, traditional treatment approaches include administration of non-steroidal anti-inflammatory drugs (NSAIDs), which act as selective or non-selective COX inhibitors. …”
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    Thiazoles and Thiazolidinones as COX/LOX Inhibitors
  18. 38
    “…OBJECTIVE: evaluate the signifcance of cyclo-oxygenase-2 (COX-2) expression in SP. METHODS: Immunohistochemistry for COX-2 was performed on SP samples and middle turbinates from chronic rhinosinusitis without nasal polyps controls obtained during surgical resection between 2009–2017. …”
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    COX-2 Overexpression in Schneiderian Papillomas
  19. 39
    Publicado 1859
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    Coxe on the Treatment of Membranous, or True Croup
  20. 40
    “…Therefore, COX inhibition by non-steroidal anti-inflammatory drugs (NSAIDs) targeted against both the isoforms COX-1 and COX-2 have been studied for decades in anticipation of preventing the occurrence of colorectal carcinoma in high-risk populations. …”
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    Colorectal Carcinoma, Cyclooxygenases, and COX Inhibitors
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