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481“…ENO1 silencing markedly elevated COX‐2, c‐Myc, and cyclin D1 expression. CONCLUSION: ENO1 may participate in the development of RM via suppressing the growth and invasion of villous trophoblasts via reducing the expression of COX‐2, c‐Myc, and cyclin D1.…”
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482por Revankar, Archana G., Bagewadi, Zabin K., Shaikh, Ibrahim Ahmed, Mannasaheb, Basheerahmed Abdulaziz, Ghoneim, Mohammed M., Khan, Aejaz Abdullatif, Asdaq, Syed Mohammed Basheeruddin“…Cyclooxygenase 2 (COX-2) participates in the inflammation process by converting arachidonic acid into prostaglandin G2 which increases inflammation, pain and fever. …”
Publicado 2023
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483“…OBJECTIVE: To evaluate RSF and Cox models for mortality prediction of hemorrhagic stroke (HS) patients in intensive care unit (ICU). …”
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484“…The results suggest that COX-2 inhibitor and PPAR ligands could serve as an effective agent against colitis-related colon cancer development.…”
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485por Bhandari, Pradeep, Bateman, Adrian C, Mehta, Raj L, Stacey, Bernard SF, Johnson, Penny, Cree, Ian A, Di Nicolantonio, Federica, Patel, Praful“…BACKGROUND: COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. …”
Publicado 2006
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486por Akarasereenont, Pravit C, Techatraisak, Kitirat, Thaworn, Athiwat, Chotewuttakorn, Sirikul“…Cyclooxygenase (COX), existing as the COX-1 and COX-2 isoforms, converts arachidonic acid to prostaglandin H2, which is then further metabolized to various prostaglandins. …”
Publicado 2002
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487por Ghosh, Mallika, Wang, Haibin, Ai, Youxi, Romeo, Elisa, Luyendyk, James P., Peters, Jeffrey M., Mackman, Nigel, Dey, Sudhansu K., Hla, Timothy“…Although cyclooxygenase (COX)-2 inhibitors (coxibs) are effective in controlling inflammation, pain, and tumorigenesis, their use is limited by the recent revelation of increased adverse cardiovascular events. …”
Publicado 2007
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488por Houssier, Marianne, Raoul, William, Lavalette, Sophie, Keller, Nicole, Guillonneau, Xavier, Baragatti, Barbara, Jonet, Laurent, Jeanny, Jean-Claude, Behar-Cohen, Francine, Coceani, Flavio, Scherman, Daniel, Lachapelle, Pierre, Ong, Huy, Chemtob, Sylvain, Sennlaub, Florian“…CD36(−/−) mice express reduced levels of COX2 and VEGF in vivo, and COX2(−/−) mice develop progressive choroidal degeneration similar to what is seen in CD36 deficiency. …”
Publicado 2008
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489“…COX-2 expression limits the ubiquitination of survivin, protecting it from degradation. …”
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490por Ferrandina, G, Lauriola, L, Zannoni, G F, Distefano, M G, Legge, F, Salutari, V, Gessi, M, Maggiano, N, Scambia, G, Ranelletti, F OEnlace del recurso
Publicado 2002
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491“…Two isoforms of cyclooxygenase (COX) participate in growth control; COX-1 is constitutively expressed in most cells, and COX-2 is an inducible enzyme in response to cellular stimuli. …”
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492por Grimminger, Peter P., Stöhlmacher, Jan, Vallböhmer, Daniel, Schneider, Paul M., Hölscher, Arnulf H., Metzger, Ralf, Danenberg, Peter V., Brabender, Jan“…Gene expression of Cyclooxygenase-2 (COX-2) has been linked to prognosis in patients with NSCLC. …”
Publicado 2009
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493Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective studypor Barisik, Nagehan O, Bozkurt, Suheyla, Gumus, Mahmut, Kaygusuz, Isik, Karadayi, Nimet, Bas, Emine, Bayik, Mahmut, Tecimer, Tulay“…BACKGROUND: Cyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. …”
Publicado 2010
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494por Chlapek, Petr, Redova, Martina, Zitterbart, Karel, Hermanova, Marketa, Sterba, Jaroslav, Veselska, Renata“…BACKGROUND: We performed expression profiling of two neuroblastoma cell lines, SK-N-BE(2) and SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and cyclooxygenases (COX). This study is a continuation of our previous work confirming the possibility of enhancing ATRA-induced cell differentiation in these cell lines by the application of LOX/COX inhibitors and brings more detailed information concerning the mechanisms of the enhancement of ATRA-induced differentiation of neuroblastoma cells. …”
Publicado 2010
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495por Chan, June M., Weinberg, Vivian, Magbanua, Mark J., Sosa, Eduardo, Simko, Jeffry, Shinohara, Katsuto, Federman, Scot, Mattie, Mike, Hughes-Fulford, Millie, Haqq, Christopher, Carroll, Peter R.“…We hypothesized that lycopene or fish oil supplements would down-regulate insulin-like growth factor-1 (IGF-1) and cyclooxygenase 2 (COX-2) gene expression, respectively, reflecting putative proliferation (IGF-1) and inflammatory (COX-2) pathways relevant to carcinogenesis. …”
Publicado 2010
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496“…Here, we studied the role of the −1 and +1 nucleotide in wheat cox2 editing site recognition using an in organello approach. …”
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497“…During this period the initiative for vaccination was taken by the girl, her family or the general practitioner/pediatrician/gynecologist. METHODS: We used a Cox regression model with time constant and time varying predictors to model hazard rates of HPV vaccination initiation. …”
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498“…Besides, PGE(2), a product of COX-2, was also under research as to whether it is involved in the upregulation of MMP-9 expression by COX-2. …”
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499por Hashimoto, Naoki“…We examined the expression of COX2 and p53 in rat esophageal lesions induced by duodenal content reflux. …”
Publicado 2012
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500“…To better understand these unexpected effects, we have recently investigated the mechanism of inhibition of human K(v)2.1 channels by a highly selective COX-2 inhibitor SC-791. In this study we have further explored the SC-791 action on ion channels and heartbeat in Drosophila, which lacks cyclooxygenases and thus can serve as a convenient model to study COX-2-independent mechanisms of coxibs. …”
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