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  1. 521
    “…Dual inhibition of the enzymes COX-1 and 5-LOX is essential for the treatment of several inflammatory diseases, but there is not much investigation reported in the literature for natural products. …”
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    A Metabolomic Approach to Target Compounds from the Asteraceae Family for Dual COX and LOX Inhibition
  2. 522
    “…The growth of murine MC-GP tumors, which show high endogenous COX-2 expression, in immunocompetent mice was effectively suppressed by treatment with a selective COX-2 inhibitor, celecoxib. …”
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    Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity
  3. 523
    “…Retinas of Ins2 Akita mice showed increased levels of AQP1 and COX-2, as well as angiogenesis, all reverted by AQP1 siRNA intravitreal injections. …”
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    High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy
  4. 524
    “…Exposure to timosaponin AIII resulted in concentration‐dependent inhibition of cell migration, which was associated with reduced levels of COX‐2, PGE (2), and PGE (2) receptors. Transient transfection of COX‐2 siRNA also inhibited cell migration. …”
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    Timosaponin AIII inhibits melanoma cell migration by suppressing COX‐2 and in vivo tumor metastasis
  5. 525
    “…RESULTS: Our data shown that t-AUCB inhibits cell proliferation, migration and invasion and induces cell cycle G1 phase arrest in vitro but induces no cell apoptosis; increased Hsp27 activation and following COX-2 overexpression confer resistance to t-AUCB treatment in glioblastoma both in vitro and in vivo; quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo. …”
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    Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo
  6. 526
    “…COX-2 is involved in tumor development and progression, and frequent overexpression of COX-2 in a variety of human cancers has made COX-2 an important drug target for cancer treatment. …”
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    PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model
  7. 527
    “…Therefore, we first discuss the rationale and the practical usage of three recently proposed network-based Cox regression algorithms (i.e., Net-Cox, AdaLnet, and fastcox). …”
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    Cancer Markers Selection Using Network-Based Cox Regression: A Methodological and Computational Practice
  8. 528
    “…Like indomethacin which inhibits cyclooxygenase-2 (COX-2) activity, POG dose-dependently decreased spinal COX-2 content in arthritic rats. …”
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    Antinociceptive Effects of Prim-O-Glucosylcimifugin in Inflammatory Nociception via Reducing Spinal COX-2
  9. 529
    por Xu, Lin, Shen, Bin, Chen, Tingting, Dong, Pin
    Publicado 2016
    “…Similarly, the expression of miR-203 and Cox-2 also has a negative correlation (P=0.0019, r=−0.46). …”
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    miR-203 is involved in the laryngeal carcinoma pathogenesis via targeting VEGFA and Cox-2
  10. 530
    “…CONCLUSION: COX-2-765CC, COX-2-765CG, COX-2-1195GG and COX-2-1195AG genotypes can increase the risk of migraine significantly. …”
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    Association of COX-2 Promoter Polymorphisms -765G/C and -1195A/G with Migraine
  11. 531
    “…Reliable predictions on the risk and survival time of prostate cancer patients based on their clinical records can help guide their treatment and provide hints about the disease mechanism. The Cox regression is currently a commonly accepted approach for such tasks in clinical applications. …”
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    DWCox: A density-weighted Cox model for outlier-robust prediction of prostate cancer survival
  12. 532
    “…Co-localization of PD-L1 and COX-2 expression was analyzed by double fluorescence staining. …”
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    COX-2 expression positively correlates with PD-L1 expression in human melanoma cells
  13. 533
    “…The prognostic significance of COX-2 in patients with breast cancer remains controversial. …”
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    Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis
  14. 534
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    The Cox-2 Inhibitor Meloxicam Ameliorates Neuroinflammation and Depressive Behavior in Adult Mice after Splenectomy
  15. 535
    “…Despite the reported advantages of ablating AF with the Cox maze procedure (CMP), the addition of the CMP may complicate other cardiac operations. …”
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    Treatment of Atrial Fibrillation in Elderly Patients with the Cox Maze Procedure Concurrently with Other Cardiac Operations
  16. 536
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    Integration of Multiple Genomic Data Sources in a Bayesian Cox Model for Variable Selection and Prediction
  17. 537
    por Irrera, Natasha, Bitto, Alessandra
    Publicado 2017
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    Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases
  18. 538
    “…In the present work, we performed a deep investigation of the aliphatic composition of the cutin, suberin, waxes, and triterpenes in the waxy and russeted patches of the semi-russeted apple variety “Cox Orange Pippin.” A targeted gene expression profiling was performed to validate candidate genes which were identified in our previous work and might be involved in the respective metabolic pathways. …”
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    Differential Lipid Composition and Gene Expression in the Semi-Russeted “Cox Orange Pippin” Apple Variety
  19. 539
    “…Here, we show that the Cox-2 and Wnt signaling pathways are aberrantly activated in GSCs and interact to maintain the cancer stem cell identity. …”
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    Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma
  20. 540
    “…BACKGROUND: The Marginal Structural Cox Model (Cox-MSM), an alternative approach to handle time-dependent confounder, was introduced for survival analysis and applied to estimate the joint causal effect of two time-dependent nonrandomized treatments on survival among HIV-positive subjects. …”
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    Performance of the marginal structural cox model for estimating individual and joined effects of treatments given in combination
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