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  1. 541
    “…Moreover, AM404 also inhibited the production of PGD(2) and the formation of reactive oxygen species (8-iso-PGF(2) alpha) with a reversible reduction of COX-1- and COX-2 activity. Also, it slightly decreased the levels of LPS-induced COX-2 protein, although no effect was observed on LPS-induced mPGES-1 protein synthesis. …”
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    AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity
  2. 542
    por Austin, Peter C.
    Publicado 2017
    “…The use of the Cox proportional hazards regression model is widespread. …”
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    Statistical power to detect violation of the proportional hazards assumption when using the Cox regression model
  3. 543
    “…Conversely, knocking down miR655 in aggressive MCF7-COX2 and SKBR3-COX2 cells reverted these phenotypes. …”
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    COX-2 induces oncogenic micro RNA miR655 in human breast cancer
  4. 544
    “…COX-2 and YAP are shown to be highly associated with hepatocellular carcinoma (HCC) and frequently upregulated during tumor formation. …”
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    COX-2 Forms Regulatory Loop with YAP to Promote Proliferation and Tumorigenesis of Hepatocellular Carcinoma Cells
  5. 545
    “…In 10 TCGA RNA-Seq data sets, Cox-nnet achieves the same or better predictive accuracy compared to other methods, including Cox-proportional hazards regression (with LASSO, ridge, and mimimax concave penalty), Random Forests Survival and CoxBoost. …”
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    Cox-nnet: An artificial neural network method for prognosis prediction of high-throughput omics data
  6. 546
    “…A new series of peptide-like derivatives containing different aromatic amino acids and possessing pharmacophores of COX-2 inhibitors as SO(2)Me or N(3 )attached to the para position of an end phenyl ring was synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. …”
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    Design, Synthesis and Biological Evaluation of Novel Peptide-Like Analogues as Selective COX-2 Inhibitors
  7. 547
    “…The results of the present study revealed that HPV16 E7 may promote the proliferation of breast cancer cells by upregulating COX-2, suggesting that COX-2 may be a potential therapeutic target for HPV16 E7-mediated progression of breast cancer.…”
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    HPV16 E7 increases COX-2 expression and promotes the proliferation of breast cancer
  8. 548
    “…One of the most frequently altered enzymes in intestinal GC is COX-2, an important lesion marker. This work aimed to study COX-2 methylation and expression in N-methyl-N-Nitrosurea (MNU)-induced intestinal GC in six Sapajus apella animals. …”
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    COX-2 gene expression and methylation profile in Sapajus apella as an experimental model for gastric adenocarcinoma
  9. 549
    por Walker, Chris
    Publicado 2018
    “…Drugs in this heterogeneous class alleviate pain and inflammation by inhibiting cyclooxygenase-2 (COX-2). Cyclooxygenase-1 (COX-1) inhibition has traditionally been associated with increased gastrointestinal (GI) harm, whereas increased COX-2 selectivity has more recently become associated with greater risk of cardiovascular (CV) harm. …”
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    Are All Oral COX-2 Selective Inhibitors the Same? A Consideration of Celecoxib, Etoricoxib, and Diclofenac
  10. 550
    “…Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E(2) (PGE(2)). …”
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    Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages
  11. 551
    “…BACKGROUND: Urothelial carcinoma of the urinary bladder (UCB) is the commonest bladder tumor. Cyclooxygenase-2 (COX-2) mediates angiogenesis, cell survival/proliferation, and apoptosis. …”
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    Increased COX-2 Immunostaining in Urothelial Carcinoma of the Urinary Bladder Is Associated with Invasiveness and Poor Prognosis
  12. 552
    “…Western blot analysis demonstrated that overexpression of miR-144-3p decreased Cox-2 expression by 38.2% in HTR-8/SVneo cells. …”
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    MicroRNA-144-3p may participate in the pathogenesis of preeclampsia by targeting Cox-2
  13. 553
    “…Myricetin exposure resulted in dose-dependent suppression of PGN-induced COX-2 expression, diminished phosphorylation of p38, extracellular signal regulated kinase 1/2, and c-Jun N-terminal kinase, and reduced IκB-α degradation, consistent with decreased COX-2 activity. …”
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    Myricetin Inhibition of Peptidoglycan-Induced COX-2 Expression in H9c2 Cardiomyocytes
  14. 554
    “…The increased COX-2 expression was detected by all tested TKIs in at least one of the tested COX-2-expressing bladder cancer cell lines (5637, SW780, TCCSUP, K9TCC#1Lillie, K9TCC#2Dakota, and K9TCC#5Lilly) in vitro. …”
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    Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A
  15. 555
    “…Cyclooxygenases (COXs), including COX-1 and -2, are enzymes essential for lipid mediator (LMs) syntheses from arachidonic acid (AA), such as prostaglandins (PGs). …”
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    Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways
  16. 556
    “…OBJECTIVE: The purpose of this study was to characterize the mitochondrial COX-1 gene of Sarcoptes scabiei in rabbits from three districts of Malang, Nganjuk, and Kediri, East Java, Indonesia. …”
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    Characterization of mitochondrial COX-1 gene of Sarcoptes scabiei from rabbits in East Java, Indonesia
  17. 557
    “…Results on the functionality of COX20 have revealed that overexpression of COX20 induced respiratory growth in Δimp1 and Δcox18, two genes whose presence is essential for yeast respiratory growth. …”
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    A Role for COX20 in Tolerance to Oxidative Stress and Programmed Cell Death in Saccharomyces cerevisiae
  18. 558
    “…We found that the formation of lamellar cristae was associated with the gain of cytochrome c oxidase (COX) function, and the COX subunit, COX4, was localized predominantly to organized lamellar cristae. …”
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    Coordinated organization of mitochondrial lamellar cristae and gain of COX function during mitochondrial maturation in Drosophila
  19. 559
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    Correction to: IL-33 facilitates proliferation of colorectal cancer dependent on COX2/PGE(2)
  20. 560
    “…One of the compounds 4 was able to inhibit the cyclooxygenase-2 (COX-2) to a greater extent than naproxen, without inhibiting cyclooxygenase-1 (COX-1), and therefore is a potential lead in the search for selective COX-2 inhibitors. …”
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    Biological Evaluation of Naproxen–Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors
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