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Mostrando 641 - 660 Resultados de 89,050 Para Buscar '"Cox"', tiempo de consulta: 0.73s Limitar resultados
  1. 641
    por Crofford, Leslie J
    Publicado 2003
    “…Clinical data suggest that protective PGs are derived from cyclooxygenase (COX)-1 because studies have now confirmed that drugs specifically inhibiting COX-2 are not cross-reactive with aspirin in patients with AERD.…”
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    COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease
  2. 642
    “…These PGF pulses are produced by the endometrial lumenal epithelium (LE) and superficial ductal glandular epithelium (sGE) in response to binding of pituitary and/or luteal oxytocin to oxytocin receptors (OTR) and liberation of arachidonic acid, the precursor of PGF. Cyclooxygenase-one (COX-1) and COX-2 are rate-limiting enzymes in PGF synthesis, and COX-2 is the major form expressed in ovine endometrium. …”
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    Effects of the estrous cycle, pregnancy and interferon tau on expression of cyclooxygenase two (COX-2) in ovine endometrium
  3. 643
    “…In a multivariate model which included size, grade, COX-2 and PPARγ positivity, we found COX-2 positivity to be a strong independent risk factor for recurrence (OR 7.90, 95% CI 1.72–36.23)., whereas size and grade were of borderline significance. …”
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    COX-2 and PPARγ expression are potential markers of recurrence risk in mammary duct carcinoma in-situ
  4. 644
    “…It is proposed that non-steroidal anti-inflammatory drugs (NSAIDs) reduce colorectal tumorigenesis by inhibition of cyclooxygenase (COX). COX is a key enzyme in the conversion of arachidonic acid to prostaglandins and two isoforms of COX have been characterized, COX-1 and COX-2. …”
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    Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522
  5. 645
    “…Recent studies have demonstrated cyclooxygenase 2 (COX-2) overexpression in various human malignancies, especially in breast cancer, where COX-2 turned out to be a predictor of poor survival. …”
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    Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival
  6. 646
    “…We have investigated the relationship between PTGS2 (COX2) polymorphisms and colorectal cancer risk in a hospital based case–control study. …”
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    Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer
  7. 647
    “…Acetaminophen, a compound with negligible COX-2 activity and low dose aspirin (81 mg) produced no significant change in the risk of colon cancer. …”
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    Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
  8. 648
    “…The role of cyclooxygenase-2 (COX-2) in oesophageal squamous carcinogenesis has not yet been investigated in this high-risk group. …”
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    Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis
  9. 649
    “…RESULTS: Interestingly, norepinephrine increased COX-2 mRNA, but not protein expression. Norepinephrine strongly enhanced COX-2 expression and PGE(2 )production induced by lipopolysaccharide (LPS). …”
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    Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE(2 )in primary rat microglia
  10. 650
    “…Non-steroidal anti-inflammatory drugs (NSAIDs) that act as cyclo-oxygenase (COX) inhibitors are commonly used in the treatment of a range of headache disorders, although their mechanism of action is unclear. …”
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    A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches
  11. 651
    “…Renal dysplasia (RD) in dogs is a complex disease with a highly variable phenotype and mode of inheritance that does not follow a simple Mendelian pattern. Cox-2 (Cyclooxgenase-2) deficient mice have renal abnormalities and a pathology that has striking similarities to RD in dogs suggesting to us that mutations in the Cox-2 gene could be the cause of RD in dogs. …”
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    Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter Are Associated with Renal Dysplasia in Dogs
  12. 652
    “…Furthermore, we found that mRNAs of vascular endothelial growth factor-A (VEGF-A) and cyclooxygenase-2 (COX-2) were upregulated in TECs. Vascular endothelial growth factor-A and COX-2 are angiogenic factors and their mRNAs contain an AU-rich element (ARE). …”
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    HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium
  13. 653
    “…BACKGROUND: To evaluate the expression of EGFR and COX-2 and their correlation with prognosis in NSCLC METHODS: The paraffin embedded tumor samples of 50 NSCLC patients receiving radical resection were analyzed immunohistochemically for EGFR and COX-2 expression and their prognostic values were explored. …”
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    EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features
  14. 654
    “…In the frame of the Cox proportional hazard (PH) model, a novel two-step procedure for estimating age-period-cohort (APC) effects on the hazard function of death from cancer was developed. …”
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    Extension of Cox Proportional Hazard Model for Estimation of Interrelated Age-Period-Cohort Effects on Cancer Survival
  15. 655
    “…BACKGROUND: Increased cyclooxygenase activity promotes progression of colorectal cancer, but the mechanisms behind COX-2 induction remain elusive. This study was therefore aimed to define external cell signaling and transcription factors relating to high COX-2 expression in colon cancer tissue. …”
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    Online Artículo Texto
    COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status
  16. 656
    “…BACKGROUND: Over-expression and increased activity of cyclooxygenase (COX)-2 induced by smoking has been implicated in the development of cancer. …”
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    Online Artículo Texto
    Smoking and COX-2 Functional Polymorphisms Interact to Increase the Risk of Gastric Cardia Adenocarcinoma in Chinese Population
  17. 657
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    Online Artículo Texto
    Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-κB pathways
  18. 658
    “…BACKGROUND: The most frequent case of horizontal transfer in plants involves a group I intron in the mitochondrial gene cox1, which has been acquired via some 80 separate plant-to-plant transfer events among 833 diverse angiosperms examined. …”
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    Online Artículo Texto
    Multiple recent horizontal transfers of the cox1 intron in Solanaceae and extended co-conversion of flanking exons
  19. 659
    “…Prognostic models are often used to estimate the length of patient survival. The Cox proportional hazards model has traditionally been applied to assess the accuracy of prognostic models. …”
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    Online Artículo Texto
    A Flexible Alternative to the Cox Proportional Hazards Model for Assessing the Prognostic Accuracy of Hospice Patient Survival
  20. 660
    “…Cyclooxygenase (COX)-2 inhibitors are widely used for postoperative pain control in clinical practice. …”
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    Online Artículo Texto
    Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling
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