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  1. 87641
    por Kwak, Soo Heon, Hernandez-Cancela, Ryan B., DiCorpo, Daniel A, Condon, David E., Merino, Jordi, Wu, Peitao, Brody, Jennifer A, Yao, Jie, Guo, Xiuqing, Ahmadizar, Fariba, Meyer, Mariah, Sincan, Murat, Mercader, Josep M., Lee, Sujin, Haessler, Jeffrey, Vy, Ha My T., Lin, Zhaotong, Armstrong, Nicole D., Gu, Shaopeng, Tsao, Noah L., Lange, Leslie A., Wang, Ningyuan, Wiggins, Kerri L., Trompet, Stella, Liu, Simin, Loos, Ruth J.F., Judy, Renae, Schroeder, Philip H., Hasbani, Natalie R., Bos, Maxime M., Morrison, Alanna C., Jackson, Rebecca D., Reiner, Alexander P., Manson, JoAnn E., Chaudhary, Ninad S., Carmichael, Lynn K., Chen, Yii-Der Ida, Taylor, Kent D., Ghanbari, Mohsen, van Meurs, Joyce, Pitsillides, Achilleas N, Psaty, Bruce M., Noordam, Raymond, Do, Ron, Park, Kyong Soo, Jukema, J Wouter, Kavousi, Maryam, Correa, Adolfo, Rich, Stephen S., Damrauer, Scott M., Hajek, Catherine, Cho, Nam H., Irvin, Marguerite R., Pankow, James S., Nadkarni, Girish N., Sladek, Robert, Goodarzi, Mark O., Florez, Jose C., Chasman, Daniel I., Heckbert, Susan R., Kooperberg, Charles, Dupuis, Josée, Malhotra, Rajeev, de Vries, Paul S., Liu, Ching-Ti, Rotter, Jerome I., Meigs, James B.
    Publicado 2023
    “…METHODS: From 16 studies of the Cohorts for Heart & Aging Research in Genomic Epidemiology (CHARGE) Consortium, we conducted a multi-ancestry time-to-event genome-wide association study (GWAS) for incident CVD among people with T2D using Cox proportional hazards models. Incident CVD was defined based on a composite of coronary artery disease (CAD), stroke, and cardiovascular death that occurred at least one year after the diagnosis of T2D. …”
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    Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus
  2. 87642
    “…RESULTS: To correlate molecular status with clinical outcome, Kaplan-Meier survival analysis of 94 consecutive patients (median age, 64 years [range, 24-82 years]; 70 men [74%]) with targeted BRAF alteration testing showed worse median intracranial PFS (BRAF variant: 3.6 months [IQR, 0.1-30.6 months]; BRAF wildtype: 11.0 months [IQR, 0.8-81.5 months]; P < .001) and OS (BRAF variant: 9.8 months [IQR, 2.5-69.4 months]; BRAF wildtype: 23.2 months [IQR, 1.1-102.5 months]; P = .005; log-rank test) in BRAF V600E variant tumors. Multivariable Cox proportional hazards regression analysis revealed that BRAF V600E status was an independent variable significantly associated with both PFS (hazard ratio [HR], 2.65; 95% CI, 1.54-4.57; P < .001) and OS (HR, 1.96; 95% CI, 1.08-3.55; P = .03). …”
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    Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy
  3. 87643
    “…METHODS: We selected subjects in the MaSTER cohort (an Italian multicenter, hospital-based cohort established in the mid-1990s that currently has enrolled over 24,000 PLWH) who initiated an INSTI-based regimen either when naïve or following a regimen switch. Cox proportional hazards regression models were fitted to evaluate associations between therapy interruptions and age, sex, nationality, transmission risk group, viral suppression status, CD4 + T-cell count, diagnosis year, cART status (naïve or experienced), and hepatitis coinfection. …”
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    Convenience, efficacy, safety, and durability of INSTI-based antiretroviral therapies: evidence from the Italian MaSTER cohort
  4. 87644
    “…Outcomes included (a) the first incident fracture and percentages of members with at least 1 fracture after 6 months post-index; (b) the number of days from index to the first incident fracture, measured as time to event in Cox proportional hazards regression analysis; and (c) total all-cause health care costs (health plan allowed amount including member cost share). …”
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    Analysis of the Comparative Effectiveness of 3 Oral Bisphosphonates in a Large Managed Care Organization: Adherence, Fracture Rates, and All-Cause Cost
  5. 87645
    “…To identify CRGs potentially linked to gastric cancer progression, we performed a univariate COX regression analysis on the gene set. Subsequently, we explored the relationship between CRGs and immune infiltration, drug sensitivity, and clinical characteristics in gastric cancer patients. …”
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    GADD45B regulates the carcinogenesis process of chronic atrophic gastritis and the metabolic pathways of gastric cancer
  6. 87646
    “…Lesion-based response criteria and OS were correlated using stratified multivariable Cox models. The concordance between OS and classifications was measured using the C statistic. …”
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    Evaluation of Intratumoral Response Heterogeneity in Metastatic Colorectal Cancer and Its Impact on Patient Overall Survival: Findings from 10,551 Patients in the ARCAD Database
  7. 87647
    por Chida-Nagai, Ayako, Masaki, Naoki, Maeda, Kay, Sasaki, Konosuke, Sato, Hiroki, Muneuchi, Jun, Ochiai, Yoshie, Murayama, Hiroomi, Tahara, Masahiro, Shiono, Atsuko, Shinozuka, Atsushi, Kono, Fumihiko, Machida, Daisuke, Toyooka, Shinichi, Sugimoto, Seiichiro, Nakamura, Kazufumi, Akagi, Satoshi, Kondo, Maiko, Kasahara, Shingo, Kotani, Yasuhiro, Koizumi, Junichi, Oda, Katsuhiko, Harada, Masako, Nakajima, Daisuke, Murata, Akira, Nagata, Hazumu, Yatsunami, Koichi, Kobayashi, Tomio, Matsunaga, Yoshikiyo, Inoue, Takahiro, Yamagishi, Hiroyuki, Nakagawa, Naomi, Ohtani, Katsuki, Yamamoto, Masaki, Ito, Yushi, Hokosaki, Tatsunori, Kuwahara, Yuta, Masutani, Satoshi, Nomura, Koji, Wada, Tsutomu, Sawada, Hirofumi, Abiko, Masayuki, Takahashi, Tatsunori, Ishikawa, Yuichi, Okada, Seigo, Naitoh, Atsushi, Toda, Takako, Ando, Tatsuya, Masuzawa, Akihiro, Hoshino, Shinsuke, Kawada, Masaaki, Nomura, Yuichi, Ueno, Kentaro, Ohashi, Naoki, Tachibana, Tsuyoshi, Cao, Yuchen, Ueda, Hideaki, Yanagi, Sadamitsu, Koide, Masaaki, Mitsushita, Norie, Higashi, Kouji, Minosaki, Yoshihiro, Hayashi, Tomohiro, Okamoto, Takashi, Kuraishi, Kenji, Ehara, Eiji, Ishida, Hidekazu, Horigome, Hitoshi, Murakami, Takashi, Takei, Kohta, Ishii, Taku, Harada, Gen, Hirata, Yasutaka, Maeda, Jun, Tatebe, Shunsuke, Ota, Chiharu, Hayabuchi, Yasunobu, Sakazaki, Hisanori, Sasaki, Takashi, Hirono, Keiichi, Suzuki, Sayo, Yasuda, Masahiro, Takeda, Atsuhito, Sawai, Madoka, Miyaji, Kagami, Kitagawa, Atsushi, Nakai, Yosuke, Kakimoto, Nobuyuki, Agematsu, Kouta, Manabe, Atsushi, Saiki, Yoshikatsu
    Publicado 2023
    “…The group with an IPVD of ≥2.0 had significantly poorer survival than the group with an IPVD <2.0 (P = .037). The Cox proportional hazards model adjusted for the presence of congenital anomaly syndromes associated with pulmonary hypertension, and age at lung biopsy showed similar results (hazard ratio 4.46; 95% confidence interval: 1.45–13.73; P = .009). …”
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    Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease
  8. 87648
    “…The Radiomics Score was derived using machine learning algorithms based on the radiomics features extracted in the regions of interest delineated on the chest CT obtained before treatment. Cox proportional hazards regression analysis was performed to identify clinical features associated with therapeutic efficacy. …”
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    Assessing treatment outcomes of chemoimmunotherapy in extensive-stage small cell lung cancer: an integrated clinical and radiomics approach
  9. 87649
    “…Associations between GEX signatures and tamoxifen effect were assessed in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+ /HER2−) tumors using Kaplan–Meier estimates and Cox regression. The prognostic effects of GEX signatures were studied in the entire cohort. …”
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    Tamoxifen-predictive value of gene expression signatures in premenopausal breast cancer: data from the randomized SBII:2 trial
  10. 87650
    “…A systematic review (completed Dec 2019) identified relevant studies (BMJ Open 2021;11:e048013). IPD were requested. Cox proportional hazards analyses related total T, SHBG, LH, DHT and E2 concentrations to risk of all-cause mortality and CVD deaths, and risk of incident CVD events. …”
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    THU652 Associations Of Testosterone, Dihydrotestosterone, Estradiol And Sex Hormone-binding Globulin With All-cause And Cardiovascular Mortality, And Incident Cardiovascular Events In Men: Individual Participant Data Meta-analyses
  11. 87651
    “…Hazard ratios (HRs) for incident diabetes were estimated using Cox regression models. Results: In the vaccination cohort, we included 167337 CoronaVac and 158378 BNT162b2 recipients with their respective 1:1 matched control. 442 (0.3%) CoronaVac recipients and 693 (0.4%) BNT162b2 recipients were COVID-19 survivors. …”
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    OR34-01 Incidence Of Diabetes Following COVID-19 Vaccination And SARS-CoV-2 Infection: A Population-Based Cohort Study
  12. 87652
    “…Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models. Results: 740,692 COVID-19 patients were included, 1:1 matched to non-COVID individuals. …”
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    FRI679 Risks Of Incident Major Osteoporotic Fractures Following SARS-CoV-2 Infection
  13. 87653
    “…Risks of stroke and AF were evaluated by hazard ratios (HRs) from the Cox proportional hazard regression models. Results: A total of 5,840 patients (2,920 SGLT2i users; 2,920 GLP-1RA users) were included (mean age 55.5 years, 56.1% men, mean HbA1c 8.9% and duration of diabetes 13.7 years). …”
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    THU338 Risks Of Stroke, Its Subtypes And Atrial Fibrillation Associated With Glucagon-like Peptide 1 Receptor Agonists Versus Sodium-glucose Cotransporter 2 Inhibitors: A Real-world Population-based Study In Hong Kong
  14. 87654
    “…Clinical, pathological and genomic data were analyzed in different Cox models to study prognostic impact of covariates for disease-free survival (DFS), progression-free survival (PFS) and overall survival (OS). …”
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    THU616 Analysis Of Germline Mutations In Patients With Sporadic Adrenocortical Carcinoma
  15. 87655
    “…Three-year ambient O(3) concentrations at each employed participant’s workplace were estimated using a two-stage machine learning model. Mixed-effects Cox proportional hazards models and linear mixed-effects models were used to examine the effect of O(3) concentrations on incident hypertension and blood pressure parameters, respectively. …”
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    Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort
  16. 87656
    por Ciccone, Giovannino, De Luca, Stefano, Oderda, Marco, Munoz, Fernando, Krengli, Marco, Allis, Simona, Baima, Carlo Giuliano, Barale, Maurizio, Bartoncini, Sara, Beldì, Debora, Bellei, Luca, Bellissimo, Andrea Rocco, Bernardi, Diego, Biamino, Giorgio, Billia, Michele, Borsa, Roberto, Cante, Domenico, Castelli, Emanuele, Cattaneo, Giovanni, Centrella, Danilo, Collura, Devis, Coppola, Pietro, Dalmasso, Ettore, Di Stasio, Andrea, Fasolis, Giuseppe, Fiorio, Michele, Garibaldi, Elisabetta, Girelli, Giuseppe, Griffa, Daniele, Guercio, Stefano, Migliari, Roberto, Molinaro, Luca, Montefiore, Franco, Montefusco, Gabriele, Moroni, Maurizio, Muto, Giovanni, Ponti di Sant’Angelo, Francesca, Ruggiero, Luca, Ruo Redda, Maria Grazia, Serao, Armando, Squeo, Maria Sara, Stancati, Salvatore, Surleti, Domenico, Varvello, Francesco, Volpe, Alessandro, Zaramella, Stefano, Zarrelli, Giovanni, Zitella, Andrea, Bollito, Enrico, Gontero, Paolo, Porpiglia, Francesco, Galassi, Claudia, Bertetto, Oscar
    Publicado 2023
    “…Comparisons were analyzed with multivariable logistic or Cox models, considering centers as clusters. RESULTS: A total of 852 male patients (median [IQR] age, 70 [64-74] years) were included, and 706 patients (82.9%) chose active surveillance, with an increasing trend over time; 109 patients (12.8%) chose RP, and 37 patients (4.3%) chose RT. …”
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    Patient and Context Factors in the Adoption of Active Surveillance for Low-Risk Prostate Cancer
  17. 87657
    “…METHODS: We present a novel Cox-regression-based methodology using time-dependent covariates to estimate the profile of the increased risk of death across time in individuals who contracted COVID-19 among a population of hip fracture patients in England (N = 98,365). …”
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    Adjusting expected deaths for mortality displacement during the COVID-19 pandemic: a model based counterfactual approach at the level of individuals
  18. 87658
    “…An analysis of prognostic factors was conducted using Cox regression. RESULTS: A total of 468 eligible patients were included. …”
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    Survival analysis of patients with advanced non-small cell lung cancer receiving EGFR-TKI treatment of Yunnan in southwestern China: a real-world study
  19. 87659
    “…Results: Among the 305 enrolled patients, 234 eligible patients were analyzed: 165 in the CIT group and 69 in the SEQ group. The COX proportional hazards model suggested a significant interaction between PD-L1 expression and OS (p = 0.006). …”
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    First-Line Chemoimmunotherapy versus Sequential Platinum-Based Chemotherapy Followed by Immunotherapy in Patients with Non-Small Cell Lung Cancer with ≤49% Programmed Death-Ligand 1 Expression: A Real-World Multicenter Retrospective Study
  20. 87660
    “…The distribution of cancer-specific survival (CSS) was estimated using the Kaplan–Meier method, and the log-rank test was used to test for significant differences in CSS. A Cox proportional hazard model was also used to assess the effect of tumor variables on CSS. …”
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    Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment
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