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  1. 861
    por Kumar, Naresh, Pruthi, Vikas
    Publicado 2014
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    Structural elucidation and molecular docking of ferulic acid from Parthenium hysterophorus possessing COX-2 inhibition activity
  2. 862
    “…Cyclooxygenase-2 (COX-2) produces prostaglandins in inflamed tissues and hence has been considered as an important target for the development of anti-inflammatory drugs since long. …”
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    Computational Structure-Based De Novo Design of Hypothetical Inhibitors against the Anti- Inflammatory Target COX-2
  3. 863
    “…Since the parent compound aspirin, inhibits both COX-1 and COX-2, we also evaluated the effects of these compounds on COX-1 and COX-2 enzyme activities and also performed modeling of the interactions between the positional isomers of NOSH-aspirin and COX-1 and COX-2 enzymes. …”
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    Positional isomerism markedly affects the growth inhibition of colon cancer cells by NOSH-aspirin: COX inhibition and modeling()
  4. 864
    “…AIM: To evaluate tecidual immunoexpression of P53, E-cadherin, Cox-2, and EGFR proteins and to correlate these findings with resected gallbladder adenocarcinoma survival. …”
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    EVALUATION OF P53, E-CADHERIN, COX-2, AND EGFR PROTEIN IMUNNOEXPRESSION ON PROGNOSTIC OF RESECTED GALLBLADDER CARCINOMA
  5. 865
    “…Consistent with the Wnt-5a regulation of miR-101b, this Wnt ligand regulates COX2 expression in a time-dependent manner in cultured hippocampal neurons. …”
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    Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons
  6. 866
    “…In the present study we examined the protective effect of celecoxib, a selective inhibitor of the inducible form of cyclooxygenase (COX-2), on dopamine (DA) cell loss in a rat model of PD. …”
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    Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease
  7. 867
    “…The constitutively-expressed cyclooxygenase 1 (COX-1) and the inducible COX-2 are both involved in the conversion of arachidonic acid (AA) to prostaglandins (PGs). …”
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    Genomic, Lipidomic and Metabolomic Analysis of Cyclooxygenase-null Cells: Eicosanoid Storm, Cross Talk, and Compensation by COX-1
  8. 868
    “…Histone K27 methylation changes are carried out by the H3 demethylase JMJD3 and are essential for COX-2 induction by LPS. The changes of the histone code are associated with cyclical methylation signatures at the promoter and gene body of COX-2 gene.…”
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    Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells
  9. 869
    “…Whether and how COX-2 contributes to CSC migration and invasion is unclear. …”
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    COX-2 Promotes Migration and Invasion by the Side Population of Cancer Stem Cell-Like Hepatocellular Carcinoma Cells
  10. 870
    “…METHODS: Analysis included 13,785 live births that occurred five years preceding the National Family Health Survey-3 (2005-06). The Cox frailty model and the traditional Cox proportional hazards models were used. …”
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    Determinants of Under-Five Mortality in Rural Empowered Action Group States in India: An Application of Cox Frailty Model
  11. 871
    “…We object to elucidate that protective effect of H(2)S on endothelium is mediated by downregulating BMP4 (bone morphogenetic protein 4)/cyclooxygenase- (COX-) 2 pathway in rats with hypertension. Methods and Results. …”
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    Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension
  12. 872
    “…Logistic regression and Cox proportional hazard models were the statistical tools of the present study. …”
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    Caesarean delivery and its correlates in Northern Region of Bangladesh: application of logistic regression and cox proportional hazard model
  13. 873
    “…COX2 knockdown inhibited the proliferation of the control cells. …”
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    mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency
  14. 874
    “…In addition, HOTAIR can interact with COX-2 to positively regulate COX-2 expression and catalytic activity. …”
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    Downregulation of HOTAIR Expression Mediated Anti-Metastatic Effect of Artesunate on Cervical Cancer by Inhibiting COX-2 Expression
  15. 875
    “…JMJD2B and COX-2 expression is upregulated in H. pylori infected mice in vivo. …”
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    JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression
  16. 876
    “…The presence of aura had no effect on the serum levels of COX-2 and visfatin.…”
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    Plasma Levels of Cyclooxygenase-2 (COX-2) and Visfatin During Different Stages and Different Subtypes of Migraine Headaches
  17. 877
    “…Formation of threshold level of 8-hydroxyoctanoic acid was quantified from COX-catalyzed DGLA peroxidation in the cancer cells that overexpress COX-2 and their delta-5-desaturases were knocked down by shRNA transfection. …”
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    Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells
  18. 878
    “…For future research, COX5B should be evaluated as a biomarker in both human urine and serum to identify sepsis.…”
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    Decreased Tissue COX5B Expression and Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury in Rats
  19. 879
    “…The PTEN/Akt pathway is a plausible candidate as it may play a role in mediating inflammation via COX-2, and has been associated with cancer progression. …”
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    Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer
  20. 880
    “…AIM: To perform a meta-analysis to investigate the association between cyclooxygenase-2 (COX-2) -1195G>A gene polymorphism and gastrointestinal cancers. …”
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    Association between COX-2 -1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis
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