“…COX6B1 over-expression and hypoxia/reoxygenation was conducted on neonatal rat cardiomyocytes. …”
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“…RESULTS: We here propose a Bayesian hierarchical Cox survival model, called the group spike-and-slab lasso Cox (gsslasso Cox), for predicting disease survival outcomes and detecting associated genes by incorporating group structures of biological pathways. …”
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“…The present study was designed to observe the effect of COX2/PGD2-related autophagy on brain injury in type 2 diabetes rats. …”
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“…METHODS: The compounds were tested for analgesic and anti-inflammatory activity by various pain models in rodents whereas the selectivity towards COX-2 receptor is determined by in vitro assay. …”
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“…We assessed Kaplan-Meier estimates of the probability to have an independent external validation. Using univariable Cox regression, we explored whether characteristics of derivation (design, location, sample size, number of predictors, presentation format, validation in derivation), reporting (participants, predictors, outcomes, performance measure, information for risk calculation), and publication (journal impact factor) are associated with time to the first independent external validation. …”
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“…Prostanoids are a large family of bioactive lipids derived from the activity of cyclooxygenase-1 (COX-1) and COX-2. Aspirin impairs the biosynthesis of all prostanoids through the irreversible inhibition of both COX isoforms. …”
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“…We hypothesized that COX and TPRs are upstream requirements for the generation of vascular ROS by ET-1. (2) Methods: ET-1-induced vascular contractions and ROS were assessed in mesenteric arterioles from wild type (+/+) and knockout (−/−) of COX1 or TPR mice infused with Ang II (400 ng/kg/min × 14 days) or a vehicle. (3) Results: Ang II infusion appeared to increase microvascular protein expression of endothelin type A receptors (ETARs), TPRs, and COX1 and 2 in COX1 and TPR +/+ mice but not in −/− mice. …”
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“…Cyclo-oxygenase (COX) inhibitors are among the most commonly used drugs in the western world for their anti-inflammatory and analgesic effects. …”
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“…Furthermore, inhibitors of nonspecific ROS, cPLA2 and COX-2 ameliorated the above renal damages. Notably, the ROS-inhibitor-treated group ameliorated not only oxidative injury but also the expression of cPLA2 and COX-2, indicating that ROS functions as the upstream signaling molecule in the inflammatory cascade of obese kidney fibrosis. …”
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“…Background: Cyclooxygenase 2 (COX-2) is involved in the initial steps of colorectal cancer (CRC) formation, playing a key role in the catalysis of arachidonic acid to prostaglandin E2 (PGE(2)). …”
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“…RESULTS: In comprehensive simulations, we found that, compared to logistic regression, Cox regression had greater power at equivalent Type I error. …”
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“…Thus, CCN2 mediates the S1P-induced upregulation of COX2 expression through the S1P(1)-mediated signaling pathway in hGL cells. …”
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“…Quantitative real-time PCR showed that the expression of LINC00528 and COX-2 was upregulated while miR-143-3p expression was down-regulated in post-MI cells. …”
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“…CONCLUSION: There is no significant difference between the use of curcumin on serum COX-2 and IL-10 levels.…”
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“…CONCLUSIONS: The Cox-filter method is indeed a handy tool to identify subtype-specific prognostic lncRNA signatures. …”
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“…BACKGROUND: The aim of this study was to investigate the expression of the nuclear receptor PPARγ, together with that of the cyclooxygenases Cox-1 and Cox-2, in breast cancer (BC) tissues and to correlate the data with several clinicobiological parameters including patient survival. …”
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“…BACKGROUND: We performed a cross-sectional survey in April–May 2018 among Rohingya in Cox’s Bazar, Bangladesh, to assess polio immunity and inform vaccination strategies. …”
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“…When EPV is low, one of the common techniques which may help to manage the problem is penalized Cox regression model (PCRM). The aim of this study was to determine the survival of dialysis patients using the PCRM in low-dimensional data with few events. …”
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“…The significant correlation of VEGF expression with COX-2 may represent the role of COX-2 in tumor angiogenesis by modulating VEGF production.…”
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