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  1. 1021
    “…OBJECTIVES: The aim of this pilot study was to investigate associations between IL-6 and COX-2 expression in gingival biopsies and both clinical diagnosis and genotypes in the IL-6 and COX-2 genes. …”
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    Association between COX-2 rs 6681231 Genotype and Interleukin-6 in Periodontal Connective Tissue. A Pilot Study
  2. 1022
    “…To measure the neuroplastic changes related to this positive early experience, Golgi-Cox staining of brain tissue is utilized. Owing to the fact that Golgi-Cox impregnation stains a discrete number of neurons rather than all of the cells, staining of the rodent brain with Golgi-Cox solution permits the visualization of entire neuronal elements, including the cell body, dendrites, axons, and dendritic spines. …”
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    Visualizing the Effects of a Positive Early Experience, Tactile Stimulation, on Dendritic Morphology and Synaptic Connectivity with Golgi-Cox Staining
  3. 1023
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    INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION
  4. 1024
    “…It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). …”
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    Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS
  5. 1025
    “…Furthermore, SIRT1 inhibited NFAT-induced COX-2 promoter activity, and reduced NFAT binding to the COX-2 promoter in PMA/Io-treated HUVECs. …”
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    The Involvement of NFAT Transcriptional Activity Suppression in SIRT1-Mediated Inhibition of COX-2 Expression Induced by PMA/Ionomycin
  6. 1026
    “…RESULTS: Although expression of integrin α3 or COX2 varied among clinical IDC samples, a statistically significant, positive correlation was detected between α3 and COX2 in both tissue microarrays (r(s) = 0.49, p < 0.001, n = 59) and archived samples (r(s) = 0.59, p < 0.0001, n = 68). …”
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    Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer
  7. 1027
    “…BACKGROUND: Prognostic value of enhanced COX-2 expression in breast cancer has been controversial for a long time. …”
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    Stromal, rather than epithelial cyclooxygenase-2 (COX-2) expression is associated with overall survival of breast cancer patients
  8. 1028
    “…Knockdown of MLK3 suppressed COX-2 expression as well as phosphorylation of MKK4/p38 and MKK3/6/JNK1/2 in HaCaT cells. …”
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    MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo
  9. 1029
    “…BACKGROUND There are hoarding documents for the biological importance of cyclooxygenase-2 (COX-2) in pancreatic carcinogenesis. We aimed to thoroughly investigate the DNA sequence variations of whole COX-2 exons in a large case-control study of pancreatic cancer by direct sequencing. …”
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    Direct Sequencing of Cyclooxygenase-2 (COX-2) Revealed an Intronic Variant rs201231411 in Iranian Patients with Pancreatic Cancer
  10. 1030
    “…Abstract. Objective: COX inhibitors and b-adrenergic blockers were recently shown to reduce cancer progression in animal models through various mechanisms. …”
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    The effect of β-adrenergic blockade and COX-2 inhibition on healing of colon, muscle, and skin in rats undergoing colonic anastomosis
  11. 1031
    “…In summary, the pretreatment with OA-NO(2) remarkably ameliorated the cisplatin-induced kidney injury in mice, possibly via the inhibition of the inflammatory response, associated with the COX-2/mPGES-1/PGE(2) cascade.…”
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    Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2/mPGES-1/PGE(2) Cascade
  12. 1032
    “…With only six genes, the CoxBoost classifier predicted the 4-year status of metastatic disease with 93% sensitivity. …”
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    Prediction of Early Breast Cancer Metastasis from DNA Microarray Data Using High-Dimensional Cox Regression Models
  13. 1033
    “…The nucleotide sequences of cox1 PCR products from the 2 F. hepatica-contaminated samples were 96.5% identical to the F. hepatica cox1 sequences in GenBank, whereas F. gigantica cox1 sequences were 46.8% similar with the sequence detected from the cox1 positive samples. …”
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    Monitoring of Fasciola Species Contamination in Water Dropwort by cox1 Mitochondrial and ITS-2 rDNA Sequencing Analysis
  14. 1034
    “…To compare various models of survival, Akaike Information Criterion and Cox-Snell Residuals were used. STATA 11 was used for data analyses. …”
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    A Comparison between Accelerated Failure-time and Cox Proportional Hazard Models in Analyzing the Survival of Gastric Cancer Patients
  15. 1035
    “…Cyclooxygenase-1 (COX-1) is implicated in ovarian cancer. However, patterns of COX expression and function have been unclear and controversial. …”
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    Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer
  16. 1036
    “…CONCLUSIONS: COX-2 methylation exists in blood leukocyte DNA but at a low level. …”
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    Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population
  17. 1037
    “…These patients were taken as a census from 16 Transplant Centers in Iran during 22 years follow-up period since October 1984 to December 2008. A Cox proportional hazards model was performed to determine the important independent predictors of graft survival after malignancy. …”
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    Risk Factors of Graft Survival After Diagnosis of Post-kidney Transplant Malignancy: Using Cox Proportional Hazard Model
  18. 1038
    “…SK-N-AS cells expressed COX-2 mRNA and produced substantial amounts of prostaglandin E(2) (PGE(2)). …”
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    The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression
  19. 1039
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    COX inhibition reduces vasodilator PGE(2) but is shown to increase levels of chemoattractant 12‐HETE in vivo in human sunburn
  20. 1040
    “…The upregulated expression of COX-2 was directly associated with increased Rho GTPase activity. …”
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    RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression
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