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  1. 1061
    “…Intrauterine injection of MRP4 inhibitor in mice prior to implantation significantly downregulated implantation markers COX-2, Claudin4 and Lif, and reduced implantation rate. …”
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    MRP4 regulates ENaC-dependent CREB/COX-2/PGE(2) signaling during embryo implantation
  2. 1062
    “…BACKGROUND: Cox proportional hazard model is the most common method for analyzing the effects of several variables on survival time. …”
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    Comparing of Cox model and parametric models in analysis of effective factors on event time of neuropathy in patients with type 2 diabetes
  3. 1063
    “…Furthermore, we found that the key products of NOS2 and COX2, NO and prostaglandin E2 (PGE2), respectively, promote feed-forward NOS2/COX2 crosstalk in both MDA-MB-468 (basal-like) and MDA-MB-231 (mesenchymal-like) TNBC cell lines in which NO induced COX2 and PGE2 induced NOS2 proteins. …”
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    Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer
  4. 1064
    “…Selective cyclooxygenase-2 (COX-2) inhibitors have been developed to minimize drug-specific side effects. …”
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    Effect of COX-2 inhibition on tendon-to-bone healing and PGE2 concentration after anterior cruciate ligament reconstruction
  5. 1065
    por Zhang, Guanhua, Gan, Ye-Hua
    Publicado 2017
    “…In summary, the results indicated that the COX-2 inhibitor celecoxib enhanced the HDAC6 inhibitor-induced antitumor effects by activating the PTEN/AKT signaling pathway.…”
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    Synergistic antitumor effects of the combined treatment with an HDAC6 inhibitor and a COX-2 inhibitor through activation of PTEN
  6. 1066
    “…This study contributes a comparative analysis of 146 mitochondrial genomes of Diptera species and found variable sites at the mt DNA cox2 gene only conserved in economically important fruit flies species. …”
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    A conserved motif within cox 2 allows broad detection of economically important fruit flies (Diptera: Tephritidae)
  7. 1067
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    Corrigendum: Taheebo Polyphenols Attenuate FFA-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of COX-2
  8. 1068
    “…BACKGROUND: The study of cyclooxygenase-2 (COX-2) inhibitors is now mired in controversy. We performed a meta-analysis to assess the efficacy and safety profile of COX-2 inhibitors in patients with advanced non-small-cell lung cancer (NSCLC). …”
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    Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis
  9. 1069
    “…The aim of the present study was to underline a number of critical parameters of laboratory material preparation and taxonomic assignment pipelines in DNA meta-barcoding experiments using the cytochrome oxidase subunit-I (coxI) barcode region, known as a suitable molecular marker for animal species identification. …”
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    Tackling critical parameters in metazoan meta-barcoding experiments: a preliminary study based on coxI DNA barcode
  10. 1070
    “…COX-2 and p53 can be promising chemotherapeutic/chemopreventive targets in UC patients.…”
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    Immunohistochemical expression of proinflammatory enzyme COX-2 and p53 in ulcerative colitis and its associated dysplasia and colorectal carcinoma
  11. 1071
    “…The present study was conducted to apply the semi-parametric Cox PH model and use parametric proportional hazards (PH) and accelerated failure time (AFT) models to identify the risk factors related to survival of TM patients. …”
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    Survival analysis of thalassemia major patients using Cox, Gompertz proportional hazard and Weibull accelerated failure time models
  12. 1072
    “…In NPC cells, COX-2 overexpression increased cell proliferation, inhibited cellular senescence and resulted in chemoresistance, while the knockdown of COX-2 reduced cell proliferation, promoted cellular senescence and overcame chemoresistance. …”
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    High COX-2 expression contributes to a poor prognosis through the inhibition of chemotherapy-induced senescence in nasopharyngeal carcinoma
  13. 1073
    “…To explore the goodness of fit of the FPSM, we compared the estimated hazard ratios and baseline cumulative hazards, both of which are necessary to the calculate individual transition probabilities, and the Markov micro-simulation models constructed using the FPSM and Cox model to determine the validity of the two Markov micro-simulation models and cost-effectiveness results. …”
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    Comparison of the flexible parametric survival model and Cox model in estimating Markov transition probabilities using real-world data
  14. 1074
    “…BACKGROUND/AIMS: COX2 and HER2 are shown to be critical in the regulation of cancer progression. …”
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    Correlated non-nuclear COX2 and low HER2 expression confers a good prognosis in colorectal cancer
  15. 1075
    “…FINDINGS: We found that TNF stimulation induced COX-2 expression in monocytes isolated from responders (Rs), whereas COX-2 expression was constitutively high and non-inducible in monocytes from PNRs. …”
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    COX-2–PGE(2) Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis
  16. 1076
    “…RESULTS: We found 87.8% of GEP-NET tissues stained positive for COX-2. QGP-1 and LCC-18 cells expressed cox-2 gene. …”
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    Expression and Molecular Regulation of the Cox2 Gene in Gastroenteropancreatic Neuroendocrine Tumors and Antiproliferation of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
  17. 1077
    “…A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. …”
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    Design, Synthesis and Biological Evaluation of New Imidazo[2,1-b]Thiazole Derivatives as Selective COX-2 Inhibitors
  18. 1078
    “…Mechanistically, mTORC1 suppressed COX-2 by phosphorylation of CREB-regulated transcription coactivator 2 (CRTC2) and subsequent dissociation of CREB to cox-2 promoter in adipocytes. …”
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    Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway
  19. 1079
    “…BACKGROUND: The cox1-barcoding approach is currently extensively used for high-throughput species delimitation and discovery. …”
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    Cox1 barcoding versus multilocus species delimitation: validation of two mite species with contrasting effective population sizes
  20. 1080
    “…The overexpression of COX-2 in lung cancer has been found in several studies, suggesting that COX-2 contributes to carcinogenesis. …”
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    COX-2 rs5275 and rs689466 polymorphism and risk of lung cancer: A PRISMA-compliant meta-analysis
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