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  1. 1081
    “…In the test dataset, normalized FDG uptake within significant brain regions from voxel-wise Cox- and ANCOVA analyses (Cox- and ANCOVA- regions of interest (ROI), respectively) and clinical variables APOE status, MMSE score and education were tested in different Cox models (adjusted for age, sex) including: (1) only clinical variables, (2) only normalized FDG uptake in ANCOVA-ROI, (3) only normalized FDG uptake from Cox-ROI, (4) clinical variables plus FDG uptake in ANCOVA-ROI, (5) clinical variables plus FDG uptake from Cox-ROI. …”
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    Prognosis of conversion of mild cognitive impairment to Alzheimer's dementia by voxel-wise Cox regression based on FDG PET data
  2. 1082
    “…Additionally, COX-2 activity was diminished, and caspase-3 activity was increased to a higher extent by phenothiazine derivative:simvastatin mixtures than by phenothiazine derivatives themselves. …”
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    The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells
  3. 1083
    “…PAAT suppressed TNF-α and TNFR1 protein expression levels, inhibited TRAIL, DR4, DR5, COX-2 and PGE2 protein expression levels; however, it did not have an effect on COX-1 protein expression in the model of GI-RI. …”
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    Positive acceleration adaptive training attenuates gastric ischemia-reperfusion injury through COX-2 and PGE2 expression
  4. 1084
    “…The activity of nuclear factor (NF)-κB (p65), cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor γ (PPAR-γ) were measured by reverse transcription-quantitative polymerase chain reaction and western blot analyses, respectively. …”
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    Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF-κB/COX-2/PPAR-γ activities
  5. 1085
    por Yang, Shan, Wu, Peng, Xiao, Jianwen, Jiang, Li
    Publicado 2019
    “…The role of cytochrome c oxidase subunit 6B1 (COX6B1) in the central nervous system remains unclear. …”
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    Overexpression of COX6B1 protects against I/R-induced neuronal injury in rat hippocampal neurons
  6. 1086
    “…Thyroid cancer is commonly seen in the clinic with a rapidly increasing incidence globally. COX-2 overexpression correlates with the pathologic type of thyroid carcinoma, and it has been suggested that COX-2 overexpression is associated with a poor prognosis. …”
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    TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway
  7. 1087
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    Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS)
  8. 1088
    “…Finally, studies using COX-2 inhibitors, COX-2 siRNA (siCOX-2) and EP1–4 antagonists, showed that RASF promotion of TREM-1 expression in monocytes was mediated by COX-2/PGE(2)/EP2,4 signaling. …”
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    Rheumatoid arthritis synovial fibroblasts promote TREM-1 expression in monocytes via COX-2/PGE(2) pathway
  9. 1089
    “…Here, we confirm that murine lymph node (LN) FRCs produce prostaglandin E(2) (PGE(2)) in a cyclooxygenase-2 (COX2)-dependent and inflammation-independent fashion. …”
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    Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts
  10. 1090
    “…ETD was used as a model cyclo-oxygenase-2 (COX-2) inhibitor to evaluate the potency of these nanovectors to increase ETD permeation and retention through human skin and cytotoxicity against squamous cell carcinoma cell line (SCC). …”
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    A comparative study: the prospective influence of nanovectors in leveraging the chemopreventive potential of COX-2 inhibitors against skin cancer
  11. 1091
    “…BACKGROUND/AIM: To construct quantitative prognostic models for colorectal cancer (CRC) based on COX-2/C-MET/KRAS expression status in clinical practice. …”
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    COX-2/C-MET/KRAS status-based prognostic nomogram for colorectal cancer: A multicenter cohort study
  12. 1092
    “…In addition, we demonstrated that the enhanced effect of aspirin on the cisplatin-induced inhibition of tumor cell growth was also mediated through the suppression of the binding activity of NF-κB to the COX-2 promoter. The combination of aspirin and cisplatin effectively attenuated the translocation of NF-κB p65/p50 from the cytoplasm to the nucleus, and abrogated the binding of NF-κB p65/p50 to the COX-2 promoter, thereby down-regulating COX-2 expression and PGE(2) synthesis. …”
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    Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter
  13. 1093
    “…On the contrary, inhibition of COX‐2 has the opposite effect in vitro as well as in the COX‐2(−/−) mouse with the lung metastasis model in vivo. …”
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    High COX‐2 expression in cancer‐associated fibiroblasts contributes to poor survival and promotes migration and invasiveness in nasopharyngeal carcinoma
  14. 1094
    “…The mRNA expression levels of COX-2, Wnt and β-catenin were significantly downregulated in TF-treated A549 cells compared with controls. …”
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    Total flavonoids suppress lung cancer growth via the COX-2-mediated Wnt/β-catenin signaling pathway
  15. 1095
    “…Cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS) overexpression results in endothelial apoptosis, thus mediating vascular endothelial injury in hyperglycaemia. …”
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    High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression
  16. 1096
    “…BACKGROUND: Cox proportional hazards regression models are used to evaluate associations between exposures of interest and time-to-event outcomes in observational data. …”
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    Incorporating sampling weights into robust estimation of Cox proportional hazards regression model, with illustration in the Multi-Ethnic Study of Atherosclerosis
  17. 1097
    “…Addition of COX inhibitor or COX-2-knockout promotes apical extrusion of RasV12 cells. …”
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    The COX-2/PGE(2) pathway suppresses apical elimination of RasV12-transformed cells from epithelia
  18. 1098
    “…METHODS: Patient biopsy samples were evaluated for COX1/2, and thromboxane A2 synthase (TBXAS) expression. …”
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    Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development
  19. 1099
    “…The aim of the present study was to evaluate the effects of the selective cyclooxygenase (COX)-2 inhibitor celecoxib on the development of uterine adenomyosis in mice. …”
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    Celecoxib, a selective COX-2 inhibitor, markedly reduced the severity of tamoxifen-induced adenomyosis in a murine model
  20. 1100
    “…Compound 3 significantly downregulated liver tissue COX‐2 gene expression.…”
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    Novel sulindac derivatives: synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity
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