“…The NP extract administration significantly attenuated the increase in IL-1β and COX-2 protein levels too (P<0.01). CONCLUSION: The beneficial effects of the NP extract are related to its ability to decrease the levels of IL-1β and COX-2.…”
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“…They are synthesized from arachidonic acid by cyclooxygenase 1 (COX1) and COX2. Although COX2 has been reported to be upregulated in the spinal cord after nerve injury, its expression and functional roles in neuropathic pain remain unclear. …”
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“…RESULTS: A total of 453 individuals in 15 populations were analyzed. The cox1 gene sequences were aligned, and 247 haplotypes were detected, 41 of these shared between populations. …”
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“…METHODS: Based on a parsimonious biomarker selection in a penalized high-dimensional Cox model (lasso or adaptive lasso), we propose a unified framework to: estimate internally the predictive accuracy metrics of the developed model (using double cross-validation); estimate the individual survival probabilities at a given timepoint; construct confidence intervals thereof (analytical or bootstrap); and visualize them graphically (pointwise or smoothed with spline). …”
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“…The effect of pretreatment CA19-9 level on overall survival was modeled by Cox proportional hazard regression. The effect of CA19-9 kinetics on overall survival was modeled by an extended Cox regression with a time varying coefficient and a time varying covariate. …”
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“…Notably, our previous studies revealed that the switch to chemoresistance in glioma cells is accompanied by a switch from the expression of CcO subunit 4 isoform 2 (COX4-2) to COX4-1. In this study, chlorpromazine induced cell cycle arrest selectively in glioma cells expressing COX4-1, and computer-simulated docking studies indicated that chlorpromazine binds more tightly to CcO expressing COX4-1 than to CcO expressing COX4-2. …”
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“…However, how COX2 is dysregulated in cCSCs is largely unknown. …”
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“…COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. …”
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“…Selective COX-2 inhibitors are non-steroidal anti-inflammatory drugs which directly target cyclooxygenase-2 (COX-2), an enzyme mainly responsible for induction of inflammation, pyresis and pain. …”
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“…Various COX-2 inhibitors cause growth inhibition of human hepatocellular carcinoma cells, but many of them act in the COX-2 independent mechanism. …”
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“…When we silenced TGF-β1 and COX-2 expression simultaneously in primary human fibroblasts, a marked increase in the apoptotic cell population occurred in contrast to those only treated with either TGF-β1 or COX-2 siRNA alone. …”
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“…Results — The Cox model provided more adequate results. Interpretation — The parameter estimates from the Fine and Gray model can be misleading if interpreted in terms of relative risk.…”
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“…Data were matched with the medico-administrative database for hospital care. A Cox proportional hazards model was stratified for the treatment group and adjusted for available socio-demographic and medical covariates to compare restricted mean survival times at different time points (1, 3, 5 and 7.5 years) between groups. …”
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“…Programmed cell death-1 ligand 1 (PD-L1), tumor-infiltrating CD8-positive T lymphocytes (CD8-positive TILs), and cyclooxygenase-2 (Cox-2) have been used as prognostic tools in patients with lung adenocarcinoma. …”
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“…Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism. …”
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“…One of the cyclooxygenase (COX) isoforms, COX‐2, is over expressed in various human cancers. …”
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“…BACKGROUND AND OBJECTIVES: The present study of survival rate of patients with non-small cell carcinoma (NSCLC) compared the efficiency of Cox semi-parametric vs. parametric models in determination of influencing factors. …”
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“…BACKGROUND AND OBJECTIVE: The incidence of lung adenocarcinoma increases rapidly, and hypoxiainducible factor-1α (HIF-1α), cyclooxygenase-2 (COX-2), E-cadherin play an important role in the proliferation and differentiation of cancer cell. …”
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“…BACKGROUND AND OBJECTIVE: It has been proved that cyclooxygenase-2 (COX-2) is a key factor in lung cancer oncogenesis.COX-2 can be induced by a number of cytokines and growth factors and can be regulated by the JAK/STAT signaling pathway.Inhibiting the expression of COX-2 can prevent the development of lung cancer.The aim fo this study is to investigate whether the epidermal growth factor (EGF) can stimulate the signal transducers and activators of transcription 5 (STAT5) as well as to discover the effects of the STAT5 signaling pathway on the COX-2 in human lung adenocarcinoma A549 cells. …”
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