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1341por El-Miligy, Mostafa M. M., Al-Kubeisi, Ahmed K., Bekhit, Mohamed G., El-Zemity, Saad R., Nassra, Rasha A., Hazzaa, Aly A.“…New thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC(50 )= 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib (IC(50 )= 0.045 µM) with high SI (316, 268, 204, and 151, respectively) comparable to celecoxib (327). …”
Publicado 2022
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1342por Wu, Donglei, Fan, Wanting, Zhang, Zheng, Tang, Jianming, Zhang, Chenping, Chen, Weixuan, Qin, Nianhong, Zheng, Yuyan“…Pyroptosis-related classification of HNSCC was conducted based on consensus clustering analysis. LASSO-Cox regression analysis was used to construct a prognostic risk model-based pyroptosis-related gene. …”
Publicado 2022
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1343por Alvi, Mughees Aizaz, Alshammari, Ayed, Asghar, Faizan, Ali, Rana Muhammad Athar, Li, Li, Saqib, Muhammad, Khan, Muhammad Kasib, Imran, Muhammad, Qamar, Warda, Askar, Hussam, Abdelsater, Naser, Fu, Bao-Quan, Yan, Hong-Bin, Jia, Wan-Zhong“…DNA was extracted and mitochondrial cox1 was amplified and sequenced. Prevalence was calculated along with a 95% confidence interval in various groups. …”
Publicado 2022
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1344“…OBJECTIVES: This study aimed to examine the effectiveness of NGOs' health communication interventions (HCIs) regarding sexual and reproductive health (SRH) among the Rohingya women living in the refugee camps in Cox’s Bazar, Bangladesh. METHODS: A camp-based cross-sectional questionnaire survey was conducted from November 10, 2019, to January 10, 2020, among 415 Rohingya married women of reproductive age (above 18–49 years) living in the refugee camp in Cox’s Bazar, Bangladesh. …”
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1345por Vunnam, Nagamani, Young, Malaney C., Liao, Elly E., Lo, Chih Hung, Huber, Evan, Been, MaryJane, Thomas, David D., Sachs, Jonathan N.“…Nimesulide is a nonsteroidal anti-inflammatory drug and a COX-2 inhibitor with antitumor and antiproliferative activities that induces apoptosis in oral, esophagus, breast, and pancreatic cancer cells. …”
Publicado 2023
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1346“…BACKGROUND: Cardiovascular disease is the leading cause of death globally. Cyclooxygenase (COX)-derived prostaglandins play an important role in cardiovascular health regulation. …”
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1358por Abdel Bar, Fatma M., Mira, Amira, Foudah, Ahmed I., Alossaimi, Manal A., Alkanhal, Shatha F., Aldaej, Alanoud M., ElNaggar, Mai H.“…All isolates recorded weak–moderate activities against COX-2. However, the polyacetylene glycoside (4) showed dual inhibition against BchE (IC(50) 14.77 ± 1.55 μM) and 5-LOX (IC(50) 34.59 ± 4.26 μM). …”
Publicado 2023
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1360por Pan, Taohua, He, Maofei, Deng, Lulu, Li, Jiang, Fan, Yanhua, Hao, Xiaojiang, Mu, Shuzhen“…The cytotoxicity, in vitro anti-inflammatory ability, and in vitro COX-2 inhibitory activity of all the compounds were evaluated. …”
Publicado 2023
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