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1661“…A case of advanced lung adenocarcinoma with rare COX7A2L-ALK (C2:A20) fusion detected by NGS was reported in Peking Union Medical College Hospital, and all cases with rare ALK fusion mutations were searched from medical datebase from January 1, 2014 to March 31, 2021, to investigate the treatment of rare ALK fusion mutations with ALK inhibitors. …”
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1662por Nakatochi, Masahiro, Sugishita, Akitaka, Watanabe, Chihiro, Fuchita, Etsuko, Mizuno, Masaaki“…For continuous clinical variables, we applied a time-dependent Cox regression model. Two types of models were applied—a linear and nonlinear model with restricted cubic splines—to assess the U-shaped association. …”
Publicado 2023
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1663por Escobar, Enrico, Gómez-Valenzuela, Fernán, Peñafiel, Cristian, Hormazábal-Hevia, Alondra, Herrera-Fuentes, Constanza, Mori-Aliaga, Diana“…Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC. …”
Publicado 2023
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1664por Sultana, Rafia, Parray, Ateeb Ahmad, Hossain, Muhammad Riaz, Aktar, Bachera, Rashid, Sabina Faiz“…This paper draws on data to identify the most vulnerable groups of people within the Rohingya and the host communities of Cox’s Bazar, Bangladesh, during the COVID-19 pandemic. …”
Publicado 2023
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1665por Kobayashi, Alisa, Hiroyama, Yota, Mamiya, Taisei, Oikawa, Masakazu, Konishi, Teruaki“…Twenty-four hours after irradiation, we observed COX-2 protein upregulation in microbeam-irradiated cells compared to that of controls. …”
Publicado 2023
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1666“…Additionally, curcumin inhibited the phosphorylation of ERK and NF-kB proteins while reducing the expression of cyclooxygenase-2 (COX-2). These findings highlight the hepatoprotective potential of curcumin against APAP-induced liver injury through the suppression of the ERK, NF-kB, and COX-2 signaling pathways.…”
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1667por Hoozemans, Jeroen JM, van Haastert, Elise S, Veerhuis, Robert, Arendt, Thomas, Scheper, Wiep, Eikelenboom, Piet, Rozemuller, Annemieke JM“…Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). …”
Publicado 2005
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1668por Mascaux, C, Martin, B, Paesmans, M, Berghmans, T, Dusart, M, Haller, A, Lothaire, P, Meert, A-P, Lafitte, J-J, Sculier, J-P“…Cyclooxygenase-2 (COX-2) is overexpressed in lung cancer, especially in adenocarcinoma (ADC). …”
Publicado 2006
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1669por Looby, Eileen, Abdel-Latif, Mohamed MM, Athié-Morales, Veronica, Duggan, Shane, Long, Aideen, Kelleher, Dermot“…METHODS: Following exposure of SKGT-4 cells to DCA, protein levels of COX-2, MAPK and PARP were examined by immunoblotting. …”
Publicado 2009
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1670por Latifah, Saiful Yazan, Armania, Nurdin, Tze, Tan Hern, Azhar, Yaacob, Nordiana, Abdul Hadi, Norazalina, Saad, Hairuszah, Ithnin, Saidi, Moin, Maznah, Ismail“…Spearman rank correlation test showed significant positive linear relationship between total β-catenin and COX-2 score (Spearman's rho = 0.616, p = 0.0001). …”
Publicado 2010
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1671por Wang, Kai-Hung, Kao, An-Pei, Chang, Chia-Cheng, Lee, Jau-Nan, Hou, Ming-Feng, Long, Cheng-Yu, Chen, Hung-Sheng, Tsai, Eing-Mei“…. ~10% for R2d); 3) enhanced expression of COX-2, HDAC6 mediated, respectively, by MAPK and PI3K/Akt pathways, and many genes associated with inflammation, metastasis, and angiogenesis. …”
Publicado 2010
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1672por Redmond, Niamh E., Raleigh, Jean, van Soest, Rob W. M., Kelly, Michelle, Travers, Simon A. A., Bradshaw, Brian, Vartia, Salla, Stephens, Kelly M., McCormack, Grace P.“…Gene trees generated using 28S rRNA, nad1 and cox1 gene data, under maximum likelihood and Bayesian approaches, are highly congruent and suggest the presence of four clades. …”
Publicado 2011
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1673por Shweash, Muhannad, Adrienne McGachy, H., Schroeder, Juliane, Neamatallah, Thikryat, Bryant, Clare E., Millington, Owain, Mottram, Jeremy C., Alexander, James, Plevin, Robin“…Furthermore, whilst promastigotes had no independent effect on iNOS or COX-2 expression, they prolonged the induction of these proteins stimulated by LPS and enhanced PGE(2) and NO production. …”
Publicado 2011
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1674“…In addition, IPE at 1 μg/mL inhibited NO production and COX-2 expression in UV-exposed fibroblasts. These findings show that IPE exhibits anti-inflammatory and anti-photoaging activities, indicating that IPE could be a potential anti-aging agent.…”
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1675por Brudvik, Kristoffer W, Paulsen, Jan E, Aandahl, Einar M, Roald, Borghild, Taskén, Kjetil“…Immunohistochemical characterization of intestines from treated and control animals revealed that expression of β-catenin, β-catenin nuclear translocation and expression of the β-catenin target genes c-Myc and COX-2 were significantly down-regulated upon Rp-8-Br-cAMPS treatment. …”
Publicado 2011
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1676por Zuo, Zhenghong, Cai, Tongjian, Li, Jingxia, Zhang, Dongyun, Yu, Yonghui, Huang, Chuanshu“…Methods: We used the luciferase reporter assay and Western blotting to determine COX-2 induction by Cr(VI). We used dominant negative mutant, genetic knockout, gene knockdown, and chromatin immunoprecipitation approaches to elucidate the signaling pathway leading to COX-2 induction. …”
Publicado 2012
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1677por Leary, Scot C., Cobine, Paul A., Nishimura, Tamiko, Verdijk, Robert M., de Krijger, Ronald, de Coo, René, Tarnopolsky, Mark A., Winge, Dennis R., Shoubridge, Eric A.“…SCO1 and SCO2 are metallochaperones whose principal function is to add two copper ions to the catalytic core of cytochrome c oxidase (COX). However, affected tissues of SCO1 and SCO2 patients exhibit a combined deficiency in COX activity and total copper content, suggesting additional roles for these proteins in the regulation of cellular copper homeostasis. …”
Publicado 2013
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1678por Ranganathan, Punithavathi Vilapakkam, Jayakumar, Calpurnia, Mohamed, Riyaz, Dong, Zheng, Ramesh, Ganesan“…Administration of netrin-1 suppressed COX-2 expression, PGE2 and thromboxane production, and neutrophil infiltration into the kidney. …”
Publicado 2013
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1679por Qiao, Li-na, Wang, Jun-ying, Yang, Yong-sheng, Chen, Shu-ping, Gao, Yong-hui, Zhang, Jian-liang, Liu, Jun-ling“…The present study was aimed to determine if cervicospinal substance P (SP) and its neurokinin-1 receptor (NK-1R), calcitonin gene-related peptide (CGRP), cyclooxygenase-1 (COX-1), and prostaglandin E2 (PGE2) were involved in electroacupuncture (EA) analgesia in neck-incision pain rats. …”
Publicado 2013
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1680por Zhu, Xiaoyan, Li, Qian, Chang, Ruimin, Yang, Dong, Song, Zongbing, Guo, Qulian, Huang, Changsheng“…Chromatin immunoprecipitation analysis revealed that curcumin dose-dependently reduced the recruitment of p300/CBP and acetyl-Histone H3/acetyl-Histone H4 to the promoter of BDNF and Cox-2 genes. A similar dose-dependent decrease of BDNF and Cox-2 in the spinal cord was also observed after curcumin treatment. …”
Publicado 2014
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